Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Chiara Rancan"'
Autor:
Hideho Okada, Lawrence Fong, Christine E Brown, Shilpa A Shahani, Paul R Walker, Meenal Sinha, Eric V Liu, Erin F Simonds, Edbert D Lu, Oscar Badillo, Shokoufeh Karimi, Whitney Tamaki, Chiara Rancan, Kira M Downey, Jacob Stultz, Lauren K McHenry, Nicole M Nasholm, Pavlina Chuntova, Anders Sundström, Vassilis Genoud, Leo D Wang, Fredrik J Swartling, William A Weiss, Mats Hellström
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Background Glioblastoma (GBM) is refractory to immune checkpoint inhibitor (ICI) therapy. We sought to determine to what extent this immune evasion is due to intrinsic properties of the tumor cells versus the specialized immune context of the brain,
Externí odkaz:
https://doaj.org/article/6b195c70cb3f48339806e87479adb50b
Publikováno v:
PLoS Pathogens, Vol 11, Iss 6, p e1004906 (2015)
The common pathogen Epstein-Barr virus (EBV) transforms normal human B cells and can cause cancer. Latent membrane protein 2A (LMP2A) of EBV supports activation and proliferation of infected B cells and is expressed in many types of EBV-associated ca
Externí odkaz:
https://doaj.org/article/e65cfbf188f344808fc0389304e32722
Autor:
Chiara Rancan, Marcel Arias-Badia, Pranay Dogra, Brandon Chen, Dvir Aran, Hai Yang, Diamond Luong, Arielle Ilano, Jacky Li, Hewitt Chang, Serena S. Kwek, Li Zhang, Lewis L. Lanier, Maxwell V. Meng, Donna L. Farber, Lawrence Fong
Publikováno v:
Nature immunology, vol 24, iss 4
Gamma delta (γδ) T cells reside within human tissues including tumors, but their function in mediating antitumor responses to immune checkpoint inhibition is unknown. Here we show that kidney cancers are infiltrated by Vδ2− γδ T cells, with eq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78925f5c0fe791383889aa586e2effb3
https://doi.org/10.1038/s41590-023-01448-7
https://doi.org/10.1038/s41590-023-01448-7
Autor:
Pavlina Chuntova, William A. Weiss, Chiara Rancan, Meenal Sinha, Erin F. Simonds, Leo D. Wang, Edbert D. Lu, Christine E. Brown, Lauren K. McHenry, Nicole M. Nasholm, Jacob Stultz, Paul R. Walker, Mats Hellström, Whitney Tamaki, Lawrence Fong, Anders Sundström, Hideho Okada, Shilpa A. Shahani, E Liu, Fredrik J. Swartling, Vassilis Genoud
BackgroundGlioblastoma (GBM) is refractory to checkpoint blockade immunotherapy (CPI). We sought to determine to what extent this immune evasion is due to intrinsic properties of the tumor cells versus the specialized immune context of the brain, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c5bda9b67d9e4706d52d535c24cd023
https://doi.org/10.1101/2020.12.01.404939
https://doi.org/10.1101/2020.12.01.404939
Autor:
Matthew H. Spitzer, Sima P. Porten, Maxwell V. Meng, Chien-Chun Steven Pai, Kathryn Allaire, Serghei Mangul, Tony Li, Elizabeth E. McCarthy, Terence W. Friedlander, Chiara Rancan, Chun Jimmie Ye, Serena S. Kwek, Dvir Aran, Eric D. Chow, Lawrence Fong, Siddharth S. Raju, Yang Sun, Arielle Ilano, Arun Burra, David Y. Oh
Publikováno v:
Cell
Summary Responses to anti-PD-1 immunotherapy occur but are infrequent in bladder cancer. The specific T cells that mediate tumor rejection are unknown. T cells from human bladder tumors and non-malignant tissue were assessed with single-cell RNA and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::556b73c8a77f9c7c757f9c5527d6b5f2
https://doi.org/10.1016/j.cell.2020.05.017
https://doi.org/10.1016/j.cell.2020.05.017
Autor:
Katherine E. Harris, Suhasini Iyer, Starlynn Clarke, Pranjali Dalvi, Duy Pham, Yuping Li, Alexander Cheung, Lawrence Fong, Preethi Sankaran, Chiara Rancan, Ben Buelow, Kevin Dang, Laura Davison, Aarti Balasubramani, Alec Starzinski
Publikováno v:
Journal of Clinical Oncology. 38:e17583-e17583
e17583 Background: Castration resistant prostate cancer (CRPC) is an incurable disease and represents a significant unmet need. Prostate specific membrane antigen (PSMA) is a protein highly expressed on the surface of prostate cancer cells; expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b171167d4a0caaa34d2241330e5e361c
https://doi.org/10.1200/jco.2020.38.15_suppl.e17583
https://doi.org/10.1200/jco.2020.38.15_suppl.e17583
Autor:
Wenji Ma, Dustin J. Carpenter, Maya Meimei Li Poon, Chiara Rancan, Janice Arakawa-Hoyt, Lawrence Fong, Masaru Kubota, Pranay Dogra, Donna L. Farber, Yufeng Shen, Rei Matsumoto, Jacky Li, Lewis L. Lanier, Puspa Thapa, Takashi Senda, Peter A. Szabo, Márta Tóth
Publikováno v:
Cell, vol 180, iss 4
Cell
Cell
Immune responses in diverse tissue sites are critical for protective immunity and homeostasis. Here, we investigate how tissue localization regulates the development and function of human natural killer (NK) cells, innate lymphocytes important for an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37067025954189ffc5314e0c9225906e
https://doi.org/10.1016/j.cell.2020.01.022
https://doi.org/10.1016/j.cell.2020.01.022
Publikováno v:
Cancer Research. 79:518-518
Introduction: The tumor microenvironment is thought to be hostile to the optimal functionality of immune cells. In addition to hypoxia, tumors have a higher interstitial pressure than normal tissue. We examined the impact of hypoxia and increased pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12bbf6e01434694dd1332adb38144419
https://doi.org/10.1158/1538-7445.am2019-518
https://doi.org/10.1158/1538-7445.am2019-518
Autor:
Aarti Balasubramani, Ute Schellenberger, Laura Davison, Nathan D. Trinklein, Harshad Ugamraj, Jacky Li, Shelley Force Aldred, Preethi Sankaran, Brett Jorgensen, Katherine E. Harris, Yuping Li, Lawrence Fong, Ben Buelow, Starlynn Clarke, Wim Van Schooten, Kevin Dang, Duy Pham, Chiara Rancan
Publikováno v:
Journal of Clinical Oncology. 37:e16519-e16519
e16519 Background: Castration resistant prostate cancer (CRPC) remains an incurable disease and new treatments are needed. Therapies directed against Prostate specific membrane antigen (PSMA) -such as radiolabeled antibodies, chimeric antigen recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a0b26c88581b704c06534cba7b00d33
https://doi.org/10.1200/jco.2019.37.15_suppl.e16519
https://doi.org/10.1200/jco.2019.37.15_suppl.e16519
Autor:
Pranay Dogra, Chiara Rancan, Wenji Ma, Marta Toth, Takashi Senda, Dustin J. Carpenter, Puspa Thapa, Peter Anthony Szabo, Yufeng Shen, Lawrence Fong, Lewis L Lanier, Donna L Farber
Publikováno v:
The Journal of Immunology. 202:129.8-129.8
Natural killer (NK) cells are innate immune cells with the inherent ability to kill tumor and virus infected cells without any prior priming. Recent studies have demonstrated the ability of NK cells to develop adaptive memory and tissue residence. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::480af105db6bf5e51549efa585d21459
https://doi.org/10.4049/jimmunol.202.supp.129.8
https://doi.org/10.4049/jimmunol.202.supp.129.8