ERK5 suppression overcomes FAK inhibitor resistance in mutant KRAS-driven non-small cell lung cancer

Autor: Chiara Pozzato, Gonçalo Outeiro-Pinho, Mirco Galiè, Giorgio Ramadori, Georgia Konstantinidou

Publikováno v: EMBO Molecular Medicine, Vol 16, Iss 10, Pp 2402-2426 (2024)

Abstract Mutated KRAS serves as the oncogenic driver in 30% of non-small cell lung cancers (NSCLCs) and is associated with metastatic and therapy-resistant tumors. Focal Adhesion Kinase (FAK) acts as a mediator in sustaining KRAS-driven lung tumors,

Externí odkaz: https://doaj.org/article/6d906eadefba4aea98f43f8cb1de0cbe

PLCγ1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia

Autor: Tina M. Schnöder, Stefan Freigang, Georgia Konstantinidou, Ralph A. Schmid, Sabina Berezowska, Alessandro Rimessi, Paolo Pinton, Johanna Baumgartner, Chiara Pozzato, Florian H. Heidel, Maria Saliakoura, Matteo Rossi Sebastiano, Lukas Bubendorf, Spasenija Savic Prince

Publikováno v: Nature cell biology

Mutant KRAS modulates the metabolic plasticity of cancer cells to confer a growth advantage during hypoxia, but the molecular underpinnings are largely unknown. Using a lipidomic screen, we found that PLCγ1 is suppressed during hypoxia in KRAS-mutan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c88a8cf87cf85ca3eae09578968f3e1f
http://europepmc.org/articles/PMC7610419

The ACSL3-LPIAT1 signaling drives prostaglandin synthesis in non-small cell lung cancer

Autor: Matteo Rossi Sebastiano, Jürg Gertsch, Mirco Galiè, Georgia Konstantinidou, Ines Reynoso-Moreno, Chiara Pozzato, Maria Saliakoura

Publikováno v: Saliakoura, Maria; Reynoso-Moreno, Inés; Pozzato, Chiara; Rossi Sebastiano, Matteo; Galié, Mirco; Gertsch, Jürg; Konstantinidou, Georgia (2020). The ACSL3-LPIAT1 signaling drives prostaglandin synthesis in non-small cell lung cancer. Oncogene, 39(14), pp. 2948-2960. Springer Nature 10.1038/s41388-020-1196-5
Oncogene

Enhanced prostaglandin production promotes the development and progression of cancer. Prostaglandins are generated from arachidonic acid (AA) by the action of cyclooxygenase (COX) isoenzymes. However, how cancer cells are able to maintain an elevated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0c68495642a6b8f40caf0d0c7e4803f

Single exposure to social defeat increases corticotropin-releasing factor and glucocorticoid receptor mRNA expression in rat hippocampus

Autor: Valentino Andreetta, Birger Jansson, Lucia Carboni, Chiara Pozzato, Francesca Marini, Roberto Arban, Enrico Domenici

Stressful life events are able to induce long-term modifications in physiological and neuroendocrine parameters that are related to the onset of several psychiatric disorders. To gain information on molecular modifications involved in long-term chang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::199a1065adbc3f43d42711cae9ceaf25
http://hdl.handle.net/11585/117741

The impact of social conflict on cardiac activity

Autor: Ezio Musso, Jaap M. Koolhaas, Andrea Sgoifo, Chiara Pozzato

Publikováno v: Prevention and Control of Aggression and the Impact on its Victims ISBN: 9781441933669

Environmental challenges of various nature, either predominantly physical or psychological, can affect cardiovascular function in a significant manner. In mammalian species where individuals live in highly organized groups (for instance primates and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb5ec9008558cc0259bc24c5137b7c21
https://doi.org/10.1007/978-1-4757-6238-9_50