ERK5 suppression overcomes FAK inhibitor resistance in mutant KRAS-driven non-small cell lung cancer

Autor: Chiara Pozzato, Gonçalo Outeiro-Pinho, Mirco Galiè, Giorgio Ramadori, Georgia Konstantinidou

Publikováno v: EMBO Molecular Medicine, Vol 16, Iss 10, Pp 2402-2426 (2024)

Abstract Mutated KRAS serves as the oncogenic driver in 30% of non-small cell lung cancers (NSCLCs) and is associated with metastatic and therapy-resistant tumors. Focal Adhesion Kinase (FAK) acts as a mediator in sustaining KRAS-driven lung tumors,

Externí odkaz: https://doaj.org/article/6d906eadefba4aea98f43f8cb1de0cbe

PLCγ1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia

Autor: Tina M. Schnöder, Stefan Freigang, Georgia Konstantinidou, Ralph A. Schmid, Sabina Berezowska, Alessandro Rimessi, Paolo Pinton, Johanna Baumgartner, Chiara Pozzato, Florian H. Heidel, Maria Saliakoura, Matteo Rossi Sebastiano, Lukas Bubendorf, Spasenija Savic Prince

Publikováno v: Nature cell biology

Mutant KRAS modulates the metabolic plasticity of cancer cells to confer a growth advantage during hypoxia, but the molecular underpinnings are largely unknown. Using a lipidomic screen, we found that PLCγ1 is suppressed during hypoxia in KRAS-mutan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c88a8cf87cf85ca3eae09578968f3e1f
http://europepmc.org/articles/PMC7610419

The ACSL3-LPIAT1 signaling drives prostaglandin synthesis in non-small cell lung cancer

Autor: Matteo Rossi Sebastiano, Jürg Gertsch, Mirco Galiè, Georgia Konstantinidou, Ines Reynoso-Moreno, Chiara Pozzato, Maria Saliakoura

Publikováno v: Saliakoura, Maria; Reynoso-Moreno, Inés; Pozzato, Chiara; Rossi Sebastiano, Matteo; Galié, Mirco; Gertsch, Jürg; Konstantinidou, Georgia (2020). The ACSL3-LPIAT1 signaling drives prostaglandin synthesis in non-small cell lung cancer. Oncogene, 39(14), pp. 2948-2960. Springer Nature 10.1038/s41388-020-1196-5
Oncogene

Enhanced prostaglandin production promotes the development and progression of cancer. Prostaglandins are generated from arachidonic acid (AA) by the action of cyclooxygenase (COX) isoenzymes. However, how cancer cells are able to maintain an elevated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0c68495642a6b8f40caf0d0c7e4803f

Delay of Ejaculation Induced by SB-277011, a Selective Dopamine D3 Receptor Antagonist, in the Rat

Autor: Pierre Clément, Chiara Pozzato, Sergio Melotto, Christian Heidbreder, François Giuliano, Laurent Alexandre

Publikováno v: The Journal of Sexual Medicine. 6:980-988

Introduction Dopamine (DA) plays a key role in different aspects of the male sexual response, including sexual motivation and arousal, penile erection, and ejaculation. The modalities of action of DA are however unclear, although the various DA recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231ab740e7dc5c713b1220f9bb63b8fe
https://doi.org/10.1111/j.1743-6109.2008.01173.x

Intermittent Exposure to Social Defeat and Open-field Test in Rats

Autor: Peter Meerlo, Chiara Pozzato, Giorgio Olivetti, Tania Costoli, Massimo Manghi, Andrea Sgoifo, Ezio Musso, Donatella Stilli

Publikováno v: Stress, 5, 23-35. Taylor & Francis Group

This study investigated the effects of exposure to an intermittent homotypic stressor on: (i) habituation of acute autonomic responsivity (i.e. cardiac sympathovagal balance and susceptibility to arrhythmias), and (ii) circadian rhythmicity of heart

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac757fa26d0f0f44d0a7b6e95d8489f
https://research.rug.nl/en/publications/c2f7c000-424e-420b-a7a3-53464c9e951b