Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Chiara Mondello"'
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110969 (2014)
The DNA damage response (DDR) is activated upon DNA damage generation to promote DNA repair and inhibit cell cycle progression in the presence of a lesion. Cellular senescence is a permanent cell cycle arrest characterized by persistent DDR activatio
Externí odkaz:
https://doaj.org/article/4e9498614d0248e6bb951fde2786c750
Autor:
Cristina Belgiovine, Roberta Frapolli, Katiuscia Bonezzi, Ilaria Chiodi, Francesco Favero, Maurizia Mello-Grand, Angelo P Dei Tos, Elena Giulotto, Giulia Taraboletti, Maurizio D'Incalci, Chiara Mondello
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e14154 (2010)
BackgroundMesenchymal and amoeboid movements are two important mechanisms adopted by cancer cells to invade the surrounding environment. Mesenchymal movement depends on extracellular matrix protease activity, amoeboid movement on the RhoA-dependent k
Externí odkaz:
https://doaj.org/article/ab26f552175c4a31926a567953d3f219
Autor:
Chiara Mondello, Elena Giulotto, Maurizio D'Incalci, Tina Colombo, Elisa de Stanchina, Samantha Zongaro
Supplementary Figure Legend from Stepwise Neoplastic Transformation of a Telomerase Immortalized Fibroblast Cell Line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c505fba4f11b52a1f02e50569e07e723
https://doi.org/10.1158/0008-5472.22364219.v1
https://doi.org/10.1158/0008-5472.22364219.v1
Autor:
Chiara Mondello, Elena Giulotto, Maurizio D'Incalci, Tina Colombo, Elisa de Stanchina, Samantha Zongaro
We have described recently a human fibroblast cell line immortalized through ectopic telomerase expression (cen3tel), in which the extension of the life span was associated with the appearance of chromosomal aberrations and with the ability to grow i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706e6830d45b8e80dd732d0c9b49e89d
https://doi.org/10.1158/0008-5472.c.6494078.v1
https://doi.org/10.1158/0008-5472.c.6494078.v1
Autor:
Chiara Mondello, Elena Giulotto, Maurizio D'Incalci, Tina Colombo, Elisa de Stanchina, Samantha Zongaro
Supplementary Figure 1 from Stepwise Neoplastic Transformation of a Telomerase Immortalized Fibroblast Cell Line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd170e504e68cf1d651b367ea0b97b8
https://doi.org/10.1158/0008-5472.22364222
https://doi.org/10.1158/0008-5472.22364222
Autor:
Celina Y. Jones, Christopher L. Williams, Sara P. Moreno, Danna K. Morris, Chiara Mondello, Jan Karlseder, Alison A. Bertuch
Publikováno v:
bioRxiv
Telomere length maintenance is crucial to cancer cell immortality. Up to 15% of cancers utilize a telomerase-independent, recombination-based mechanism termed alternative lengthening of telomeres (ALT). The primary ALT biomarker is the C-circle, a ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae9249f344609f1a9cf4c1e991fe2d83
https://doi.org/10.1101/2023.01.26.525615
https://doi.org/10.1101/2023.01.26.525615
Autor:
Celina Y. Jones, Christopher L. Williams, Sara Priego Moreno, Danna K. Morris, Chiara Mondello, Jan Karlseder, Alison A. Bertuch
Publikováno v:
Journal of Biological Chemistry. 299:104665
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d49219a7294fa245537cc65555f0b392
https://doi.org/10.1016/j.jbc.2023.104665
https://doi.org/10.1016/j.jbc.2023.104665
Publikováno v:
Oncology reports. 45(6)
During tumorigenesis, oncogene activation and metabolism rewiring are interconnected. Activated c‑Myc upregulates several genes involved in glutamine metabolism, making cancer cells dependent on high levels of this amino acid to survive and prolife
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72bc861582b9ca220923412ce1eb1a7d
https://pubmed.ncbi.nlm.nih.gov/33846803
https://pubmed.ncbi.nlm.nih.gov/33846803
Autor:
Ilaria Chiodi, Chiara Mondello
Publikováno v:
Mutation research. Reviews in mutation research. 784
Cancers are heterogeneous tissues and a layer of heterogeneity is determined by the presence of cells showing stemness traits, known as cancer stem cells (CSCs). Evidence indicates that CSCs are important players in tumor development, progression and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9398d3b0a23c47089b14d01a97df9d90
https://pubmed.ncbi.nlm.nih.gov/32430096
https://pubmed.ncbi.nlm.nih.gov/32430096
Autor:
Alison A. Bertuch, Danna K. Morris, Celina Y. Jones, Christopher L. Williams, Sandra M. Indiviglio, Alessandro Baldan, Chiara Mondello, Ilaria Chiodi, Elif Asik, Ann T. Sukumar
The Ku heterodimer (Ku70/Ku80) binds DNA ends with high affinity but without sequence specificity and, upon binding ends created by double-stranded breaks (DSBs), initiates canonical nonhomologous end-joining (c-NHEJ). Ku also localizes to functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea44cefd8b5a27a46ae065bfc486236
https://doi.org/10.1101/2019.12.11.873422
https://doi.org/10.1101/2019.12.11.873422