Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Chiara Merigliano"'
Autor:
Maria Dilia Palumbieri, Chiara Merigliano, Daniel González-Acosta, Danina Kuster, Jana Krietsch, Henriette Stoy, Thomas von Känel, Svenja Ulferts, Bettina Welter, Joël Frey, Cyril Doerdelmann, Andrea Sanchi, Robert Grosse, Irene Chiolo, Massimo Lopes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Cells rapidly respond to replication stress actively slowing fork progression and inducing fork reversal. How replication fork plasticity is achieved in the context of nuclear organization is currently unknown. Using nuclear actin probes in
Externí odkaz:
https://doaj.org/article/9ce0187fdcd948fb8a159bba559a5fee
Autor:
Mattia La Torre, Chiara Merigliano, Klizia Maccaroni, Alexandre Chojnowski, Wah Ing Goh, Maria Giubettini, Fiammetta Vernì, Cristina Capanni, Daniela Rhodes, Graham Wright, Brian Burke, Silvia Soddu, Romina Burla, Isabella Saggio
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-17 (2022)
Abstract Background Lamins, key nuclear lamina components, have been proposed as candidate risk biomarkers in different types of cancer but their accuracy is still debated. AKTIP is a telomeric protein with the property of being enriched at the nucle
Externí odkaz:
https://doaj.org/article/094aad5334ef43d49206cb25055b6444
AKTIP interacts with ESCRT I and is needed for the recruitment of ESCRT III subunits to the midbody.
Autor:
Chiara Merigliano, Romina Burla, Mattia La Torre, Simona Del Giudice, Hsiangling Teo, Chong Wai Liew, Alexandre Chojnowski, Wah Ing Goh, Yolanda Olmos, Klizia Maccaroni, Maria Giubettini, Irene Chiolo, Jeremy G Carlton, Domenico Raimondo, Fiammetta Vernì, Colin L Stewart, Daniela Rhodes, Graham D Wright, Brian E Burke, Isabella Saggio
Publikováno v:
PLoS Genetics, Vol 17, Iss 8, p e1009757 (2021)
To complete mitosis, the bridge that links the two daughter cells needs to be cleaved. This step is carried out by the endosomal sorting complex required for transport (ESCRT) machinery. AKTIP, a protein discovered to be associated with telomeres and
Externí odkaz:
https://doaj.org/article/bc66149e25c047faa2127e3e143af22e
Autor:
Elisa Mascolo, Anna Barile, Lorenzo Stufera Mecarelli, Noemi Amoroso, Chiara Merigliano, Arianna Massimi, Isabella Saggio, Torben Hansen, Angela Tramonti, Martino Luigi Di Salvo, Fabrizio Barbetti, Roberto Contestabile, Fiammetta Vernì
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Abstract In eukaryotes, pyridoxal kinase (PDXK) acts in vitamin B6 salvage pathway to produce pyridoxal 5′-phosphate (PLP), the active form of the vitamin, which is implicated in numerous crucial metabolic reactions. In Drosophila, mutations in the
Externí odkaz:
https://doaj.org/article/98cbd0cfb2e64e8c8b4f5fe2009a0e66
Autor:
Federico Tommaso Bianchi, Chiara Tocco, Gianmarco Pallavicini, Yifan Liu, Fiammetta Vernì, Chiara Merigliano, Silvia Bonaccorsi, Nadia El-Assawy, Lorenzo Priano, Marta Gai, Gaia Elena Berto, Alessandra Maria Adelaide Chiotto, Francesco Sgrò, Alessia Caramello, Laura Tasca, Ugo Ala, Francesco Neri, Salvatore Oliviero, Alessandro Mauro, Stephan Geley, Maurizio Gatti, Ferdinando Di Cunto
Publikováno v:
Cell Reports, Vol 18, Iss 7, Pp 1674-1686 (2017)
Mutations in citron (CIT), leading to loss or inactivation of the citron kinase protein (CITK), cause primary microcephaly in humans and rodents, associated with cytokinesis failure and apoptosis in neural progenitors. We show that CITK loss induces
Externí odkaz:
https://doaj.org/article/439c9fc4b61d4ba8b1c56e6b173b51f6
Autor:
Elisa Mascolo, Francesco Liguori, Lorenzo Stufera Mecarelli, Noemi Amoroso, Chiara Merigliano, Susanna Amadio, Cinzia Volonté, Roberto Contestabile, Angela Tramonti, Fiammetta Vernì
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2, p 918 (2021)
Maturity-onset diabetes of the young (MODY) type 2 is caused by heterozygous inactivating mutations in the gene encoding glucokinase (GCK), a pivotal enzyme for glucose homeostasis. In the pancreas GCK regulates insulin secretion, while in the liver
Externí odkaz:
https://doaj.org/article/6b5ce63c808d4762ad3cc7f05dd3fe7e
Autor:
Romina Burla, Mattia La Torre, Giorgia Zanetti, Alex Bastianelli, Chiara Merigliano, Simona Del Giudice, Alessandro Vercelli, Ferdinando Di Cunto, Marina Boido, Fiammetta Vernì, Isabella Saggio
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Epilepsy is a complex clinical condition characterized by repeated spontaneous seizures. Seizures have been linked to multiple drivers including DNA damage accumulation. Investigation of epilepsy physiopathology in humans imposes ethical and practica
Externí odkaz:
https://doaj.org/article/2d529d953eb344e79f1020c24bcf3ea6
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Pyridoxal 5′-phosphate (PLP), the active form of vitamin B6, works as cofactor in numerous enzymatic reactions and it behaves as antioxidant molecule. PLP deficiency has been associated to many human pathologies including cancer and diabetes and th
Externí odkaz:
https://doaj.org/article/c477b98d6169496eb87e9d846d91a14a
Publikováno v:
PLoS Genetics, Vol 10, Iss 3, p e1004199 (2014)
Pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, has been implicated in preventing human pathologies, such as diabetes and cancer. However, the mechanisms underlying the beneficial effects of PLP are still unclear. Using Drosophila as a m
Externí odkaz:
https://doaj.org/article/b171c8e551074310b3e4fa5fa91eb36c
Autor:
Maria Dilia Palumbieri, Chiara Merigliano, Daniel González Acosta, Thomas von Känel, Bettina Welter, Henriette Stoy, Jana Krietsch, Svenja Ulferts, Andrea Sanchi, Robert Grosse, Irene Chiolo, Massimo Lopes
Publikováno v:
bioRxiv
Cells rapidly respond to replication stress actively slowing fork progression and inducing fork reversal. How replication fork plasticity is achieved in the context of nuclear organization is currently unknown. Using nuclear actin probes in living an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::859d8a9fd3cbd8f88f59be0633e641af
https://doi.org/10.1101/2023.03.24.534097
https://doi.org/10.1101/2023.03.24.534097
