Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Chiara Marcozzi"'
Autor:
Ahmed Abdelbaki, Camilla Ascanelli, Cynthia N. Okoye, Begum Akman, Giacomo Janson, Mingwei Min, Chiara Marcozzi, Anja Hagting, Rhys Grant, Maria De Luca, Italia Anna Asteriti, Giulia Guarguaglini, Alessandro Paiardini, Catherine Lindon
Mitotic kinase Aurora A (AURKA) diverges from other kinases in its multiple active conformations that may explain its interphase roles and association with cancer, and the limited efficacy of drugs targeting the kinase pocket. Regulation of AURKA act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81a712b9078b47556ddd991abb74a9b0
https://doi.org/10.1101/2022.01.31.478464
https://doi.org/10.1101/2022.01.31.478464
Autor:
Ahmed, Abdelbaki, Camilla, Ascanelli, Cynthia N, Okoye, H Begum, Akman, Giacomo, Janson, Mingwei, Min, Chiara, Marcozzi, Anja, Hagting, Rhys, Grant, Maria, De Luca, Italia Anna, Asteriti, Giulia, Guarguaglini, Alessandro, Paiardini, Catherine, Lindon
Publikováno v:
Life science alliance. 6(2)
Mitotic kinase Aurora A (AURKA) diverges from other kinases in its multiple active conformations that may explain its interphase roles and the limited efficacy of drugs targeting the kinase pocket. Regulation of AURKA activity by the cell is critical
Autor:
Ahmed Abdelbaki, Camilla Ascanelli, Cynthia N Okoye, H Begum Akman, Giacomo Janson, Mingwei Min, Chiara Marcozzi, Anja Hagting, Rhys Grant, Maria De Luca, Italia Anna Asteriti, Giulia Guarguaglini, Alessandro Paiardini, Catherine Lindon
Publikováno v:
Life Science Alliance. 6:e202201372
Mitotic kinase Aurora A (AURKA) diverges from other kinases in its multiple active conformations that may explain its interphase roles and the limited efficacy of drugs targeting the kinase pocket. Regulation of AURKA activity by the cell is critical
Autor:
Jonathon Pines, Jyoti S. Choudhary, Martina Barbiero, Adam L. Tyson, Chiara Marcozzi, Lu Yu, Mercedes Pardo, Mark Jackman
Publikováno v:
The Journal of Cell Biology
Jackman and colleagues show that Cyclin B1-Cdk1, the major mitotic kinase, binds to the spindle checkpoint protein MAD1 and synergizes with MPS1 to facilitate MAD1 release from the nuclear pore complex and recruitment to kinetochores before nuclear e
Autor:
Anna Zachariou, Esther Uijttewaal, Shawn Yost, Richarda M. de Voer, Susan Picton, Bas de Wolf, Anna Elliott, Chiara Marcozzi, Sarah F. Smithson, Gunnar Houge, Elise Ruark, Sandra Hanks, Emma Ramsay, Harriet Wylie, Jonathon Pines, Sheila Seal, Nazneen Rahman, Matthew Clarke, Banafsheh Etemad, Geert J. P. L. Kops, Audrey Smith
Publikováno v:
Nature Genetics, 49, 7, pp. 1148-1151
Nature Genetics, 49, 1148-1151
Nature Genetics, 49(7), 1148-1151. Nature Publishing Group
Nature Genetics, 49, 1148-1151
Nature Genetics, 49(7), 1148-1151. Nature Publishing Group
Through exome sequencing, we identified six individuals with biallelic loss-of-function mutations in TRIP13. All six developed Wilms tumor. Constitutional mosaic aneuploidies, microcephaly, developmental delay and seizures, which are features of mosa
Autor:
Mercedes Pardo, Chiara Marcozzi, Jonathon Pines, Mark Jackman, Jyoti S. Choudhary, Lu Yu, Adam L. Tyson
How the cell completely reorganises its architecture when it divides is a problem that has fascinated researchers for almost 150 years. We now know that the core regulatory machinery is highly conserved in eukaryotes but how these multiple protein ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876742421f7b486e12dc2b21ce66ae2b
Autor:
Chiara, Marcozzi, Jonathon, Pines
Publikováno v:
Methods in cell biology. 144
The spindle assembly checkpoint (SAC) is crucial to maintain genomic stability since it prevents premature separation of sister chromatids in mitosis and ensures the fidelity of chromosome segregation. The SAC arrests cells in mitosis and is not sati
Autor:
Chiara Marcozzi, Jonathon Pines
The spindle assembly checkpoint (SAC) is crucial to maintain genomic stability since it prevents premature separation of sister chromatids in mitosis and ensures the fidelity of chromosome segregation. The SAC arrests cells in mitosis and is not sati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6368b3977cc6e53b8c27af57bca32aed
https://doi.org/10.1016/bs.mcb.2018.03.001
https://doi.org/10.1016/bs.mcb.2018.03.001
Autor:
Maria Alessandra Santucci, Chiara Marcozzi, Manuela Mancini, Elisa Leo, Enza Barbieri, Michela Aluigi, Enrica Borsi
The advantage of Aurora kinase (AK) inhibitors in chronic myeloid leukemia (CML) therapy mostly arises from “off-target” effects on tyrosine kinase (TK) activity of wild type (wt) or mutated Bcr-Abl proteins which drive the disease resistance to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0667c9ed3886f5851b23bb253c430ca
http://hdl.handle.net/11585/384294
http://hdl.handle.net/11585/384294
Autor:
Oliver T. Fackler, Chiara Marcozzi, Maria De Luca, Nicola Whiffin, Johnathan Watkins, Catherine Lindon, Mingwei Min, Suzanne Floyd, Stefan Kutscheidt, Kathryn Chung, Maria P. Gavilan
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Floyd, Suzanne et al.
Spatiotemporal regulation of mitotic kinase activity underlies the extensive rearrangement of cellular components required for cell division. One highly dynamic mitotic kinase is Aurora-B (AurB), which has multiple roles de
Spatiotemporal regulation of mitotic kinase activity underlies the extensive rearrangement of cellular components required for cell division. One highly dynamic mitotic kinase is Aurora-B (AurB), which has multiple roles de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59f7eed45a59a1bbe67dfa3ecec0f45
http://hdl.handle.net/10261/122684
http://hdl.handle.net/10261/122684