Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Chiara M. Evans"'
Autor:
Tatiana Erazo, Chiara M. Evans, Daniel Zakheim, Eren L. Chu, Alice Yunsi Refermat, Zahra Asgari, Xuejing Yang, Mariana Da Silva Ferreira, Sanjoy Mehta, Marco Vincenzo Russo, Andrea Knezevic, Xi-Ping Zhang, Zhengming Chen, Myles Fennell, Ralph Garippa, Venkatraman Seshan, Elisa de Stanchina, Olena Barbash, Connie Lee Batlevi, Christina S. Leslie, Ari M. Melnick, Anas Younes, Michael G. Kharas
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Abstract To identify drivers of sensitivity and resistance to Protein Arginine Methyltransferase 5 (PRMT5) inhibition, we perform a genome-wide CRISPR/Cas9 screen. We identify TP53 and RNA-binding protein MUSASHI2 (MSI2) as the top-ranked sensitizer
Externí odkaz:
https://doaj.org/article/ae7897107ec04e2091ae2adabb8a333a
Autor:
Juliet O. Obi, Mulu Y. Lubula, Gabriel Cornilescu, Amy Henrickson, Kara McGuire, Chiara M. Evans, Margaret Phillips, Samuel P. Boyson, Borries Demeler, John L. Markley, Karen C. Glass
Publikováno v:
Current Research in Structural Biology, Vol 2, Iss , Pp 104-115 (2020)
Bromodomain-containing proteins are often part of chromatin-modifying complexes, and their activity can lead to altered expression of genes that drive cancer, inflammation and neurological disorders in humans. Bromodomain-PHD finger protein 1 (BRPF1)
Externí odkaz:
https://doaj.org/article/373be060f02e4b3cb3c3da481b1aace9
Autor:
Coraline Mlynarczyk, Matt Teater, Juhee Pae, Christopher R. Chin, Ling Wang, Theinmozhi Arulraj, Darko Barisic, Antonin Papin, Kenneth B. Hoehn, Ekaterina Kots, Jonatan Ersching, Arnab Bandyopadhyay, Ersilia Barin, Hui Xian Poh, Chiara M. Evans, Amy Chadburn, Zhengming Chen, Hao Shen, Hannah M. Isles, Benedikt Pelzer, Ioanna Tsialta, Ashley S. Doane, Huimin Geng, Muhammad Hassan Rehman, Jonah Melnick, Wyatt Morgan, Diu T. T. Nguyen, Olivier Elemento, Michael G. Kharas, Samie R. Jaffrey, David W. Scott, George Khelashvili, Michael Meyer-Hermann, Gabriel D. Victora, Ari Melnick
Publikováno v:
Science. 379
Multicellular life requires altruistic cooperation between cells. The adaptive immune system is a notable exception, wherein germinal center B cells compete vigorously for limiting positive selection signals. Studying primary human lymphomas and deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89af1728240b964263f280725c1cf48f
https://doi.org/10.1126/science.abj7412
https://doi.org/10.1126/science.abj7412
Autor:
Karen C. Glass, Cameron Montgomery, Jonathan T. Lloyd, Kyle McLaughlin, Matthew R. Marunde, Chiara M. Evans, Samuel P. Boyson, Michael‐Christopher Keogh, Seth Frietze
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e82c9b73f62936c1df5f92796891fe4
https://doi.org/10.1096/fasebj.2022.36.s1.0r269
https://doi.org/10.1096/fasebj.2022.36.s1.0r269
Autor:
Jonathan T. Lloyd, Kyle McLaughlin, Mulu Y. Lubula, Jamie C. Gay, Andrea Dest, Cong Gao, Margaret Phillips, Marco Tonelli, Gabriel Cornilescu, Matthew R. Marunde, Chiara M. Evans, Samuel P. Boyson, Samuel Carlson, Michael-Christopher Keogh, John L. Markley, Seth Frietze, Karen C. Glass
Publikováno v:
J Med Chem
Bromodomains are chromatin reader modules that recognize acetylated lysine. Different bromodomains exhibit a preference for specific patterns of lysine acetylation marks on core and variant histone proteins, however, the functional relationships that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8961c303018439c9f7b6ef608f6fb1de
https://doi.org/10.1021/acs.jmedchem.0c01178
https://doi.org/10.1021/acs.jmedchem.0c01178
Autor:
Mulu Y. Lubula, Margaret Phillips, Gabriel Cornilescu, Juliet O. Obi, Karen C. Glass, Samuel P. Boyson, John L. Markley, Amy Henrickson, Chiara M. Evans, Kara McGuire, Borries Demeler
Publikováno v:
Current Research in Structural Biology, Vol 2, Iss, Pp 104-115 (2020)
Curr Res Struct Biol
Curr Res Struct Biol
Bromodomain-containing proteins are often part of chromatin-modifying complexes, and their activity can lead to altered expression of genes that drive cancer, inflammation and neurological disorders in humans. Bromodomain-PHD finger protein 1 (BRPF1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89bf6d9c227e0c9391b055a21403786e
http://www.sciencedirect.com/science/article/pii/S2665928X20300106
http://www.sciencedirect.com/science/article/pii/S2665928X20300106
Autor:
Tatiana Erazo, Chiara M. Evans, Daniel Zakheim, Karen L. Chu, Alice Yunsi Refermat, Zahra Asgari, Xuejing Yang, Mariana Da Silva Ferreira, Sanjoy Mehta, Marco Vincenzo Russo, Andrea Knezevic, Xi-Ping Zhang, Zhengming Chen, Myles Fennell, Ralph Garippa, Venkatraman Seshan, Elisa de Stanchina, Olena Barbash, Connie Lee Batlevi, Christina S. Leslie, Ari M. Melnick, Anas Younes, Michael G. Kharas
Publikováno v:
Nature communications. 13(1)
To identify drivers of sensitivity and resistance to Protein Arginine Methyltransferase 5 (PRMT5) inhibition, we perform a genome-wide CRISPR/Cas9 screen. We identify TP53 and RNA-binding protein MUSASHI2 (MSI2) as the top-ranked sensitizer and drive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be7e429b6aac6d3fecd6a10f5b0a27b5
https://pubmed.ncbi.nlm.nih.gov/36167829
https://pubmed.ncbi.nlm.nih.gov/36167829
Autor:
Samuel Carlson, Liping Wang, Jay C. Nix, John L. Markley, Marco Tonelli, Mátyás Gorjánácz, Gabriel Cornilescu, Karen C. Glass, Claudia C. Cornilescu, Simon Holton, Borries Demeler, Kiera L. Malone, Margaret Phillips, Chiara M. Evans
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 17
International Journal of Molecular Sciences, Vol 22, Iss 9128, p 9128 (2021)
Volume 22
Issue 17
International Journal of Molecular Sciences, Vol 22, Iss 9128, p 9128 (2021)
The ATPase Family, AAA domain-containing protein 2 (ATAD2) bromodomain (BRD) has a canonical bromodomain structure consisting of four α-helices. ATAD2 functions as a co-activator of the androgen and estrogen receptors as well as the MYC and E2F tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c50023c5c81009fd4eee151f65f70aa
Autor:
Jamie C. Gay, Brian E. Eckenroth, Chiara M. Evans, Cassiano Langini, Samuel Carlson, Jonathan T. Lloyd, Amedeo Caflisch, Karen C. Glass
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 87:157-167
The ATPase family, AAA domain-containing protein 2 (ATAD2) has a C-terminal bromodomain, which functions as a chromatin reader domain recognizing acetylated lysine on the histone tails within the nucleosome. ATAD2 is overexpressed in many cancers and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f35063896386cbdc18f1b78624ed60e
https://doi.org/10.1002/prot.25636
https://doi.org/10.1002/prot.25636
Autor:
Juliet O. Obi, Keiko Maekawa, Karen C. Glass, Sonia Parikh, Qinghai Zhang, Manish B. Shah, Chiara M. Evans
Publikováno v:
Mol Pharmacol
The human CYP2C9 plays a crucial role in the metabolic clearance of a wide range of clinical therapeutics. The *2 allele is a prevalent genetic variation in CYP2C9 that is found in various populations. A marked reduction of catalytic activity toward
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be8903328728f0b4607f43f474fb85c
https://pubmed.ncbi.nlm.nih.gov/32938720
https://pubmed.ncbi.nlm.nih.gov/32938720