Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Chiara Loeffler"'
Autor:
Max Jung, Michael Rose, Ruth Knuechel, Chiara Loeffler, Hannah Muti, Jakob Nikolas Kather, Nadine T. Gaisa, on behalf of the German Study Group of Bladder Cancer (DFBK e.V.)
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-15 (2023)
Abstract Aims Immune checkpoint inhibitor (ICI) therapy has become a viable treatment strategy in bladder cancer. However, treatment responses vary, and improved biomarkers are needed. Crucially, the characteristics of immune cells remain understudie
Externí odkaz:
https://doaj.org/article/0db6878676a3411cbeebdae8b7857347
Autor:
Chiara Loeffler, Lancelot Seillier, Max Jung, Ruth Knuechel, Titus J. Brinker, Jakob Nikolas Kather, Narmin Ghaffari Laleh, Nadine T. Gaisa, Michael Rose, Christian Trautwein, Nadina Ortiz Bruechle
Publikováno v:
European Urology Focus. 8:472-479
Fibroblast growth factor receptor (FGFR) inhibitor treatment has become the first clinically approved targeted therapy in bladder cancer. However, it requires previous molecular testing of each patient, which is costly and not ubiquitously available.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6bc21b38e4f4878b6a0ca670c4a2e89
https://doi.org/10.1016/j.euf.2021.04.007
https://doi.org/10.1016/j.euf.2021.04.007
Autor:
Faisal Mahmood, Nadine T. Gaisa, Roman D. Buelow, Chiara Loeffler, Firas Khader, Peter Boor, Heike I. Grabsch, Elizabeth Alwers, Titus J. Brinker, Hermann Brenner, Volkmar Schulz, Jakob Nikolas Kather, Amelie Echle, Hannah Sophie Muti, Michael Hoffmeister, Rupert Langer, Christian Trautwein, Ming Y. Lu, Bastian Dislich, Jenny Chang-Claude, Oliver Lester Saldanha, Daniel Truhn, Narmin Ghaffari Laleh
Artificial intelligence (AI) can extract subtle visual information from digitized histopathology slides and yield scientific insight on genotype-phenotype interactions as well as clinically actionable recommendations. Classical weakly supervised pipe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f9297d9db6cc4508b201536cc584bcd
https://doi.org/10.1101/2021.08.09.455633
https://doi.org/10.1101/2021.08.09.455633
Autor:
Peter Boor, Chiara Loeffler, Akash Patnaik, Heike I. Grabsch, Jefree J. Schulte, Piet A. van den Brandt, Kai A. J. Sommer, Alexander T. Pearson, Loes F. S. Kooreman, Lara R. Heij, Jakob Nikolas Kather, Amelie Echle, Nadina Ortiz-Brüchle, Jan M. Niehues, Andrew Srisuwananukorn, Hermann Brenner, Nicole A. Cipriani, Andrew M. Hanby, Peter Bankhead, Hannah Sophie Muti, Sara Kochanny, Valerie Speirs, Roman D. Buelow, Jeremias Krause, Michael Hoffmeister, Tom Luedde, Dirk Jäger, Christian Trautwein
Publikováno v:
Nature Cancer, 1(8), 789-799. Nature Publishing Group
Nat Cancer
Nature Cancer
Kather, J N, Heij, L R, Grabsch, H, Loeffler, C, Echle, A, Muti, H S, Krause, J, Niehues, J M, Sommer, K A J, Bankhead, P, Kooreman, L F S, Schulte, J J, Cipriani, N A, Buelow, R D, Boor, P, Ortiz-Bruchle, N, Hanby, A M, Speirs, V, Kochanny, S, Patnaik, A, Srisuwananukorn, A, Brenner, H, Hoffmeister, M, Brandt, P A V D, Jäger, D, Trautwein, C, Pearson, A T & Luedde, T 2020, ' Pan-cancer image-based detection of clinically actionable genetic alterations ', nature cancer, vol. 1, no. 8, pp. 789–799 . https://doi.org/10.1038/s43018-020-0087-6
Nat Cancer
Nature Cancer
Kather, J N, Heij, L R, Grabsch, H, Loeffler, C, Echle, A, Muti, H S, Krause, J, Niehues, J M, Sommer, K A J, Bankhead, P, Kooreman, L F S, Schulte, J J, Cipriani, N A, Buelow, R D, Boor, P, Ortiz-Bruchle, N, Hanby, A M, Speirs, V, Kochanny, S, Patnaik, A, Srisuwananukorn, A, Brenner, H, Hoffmeister, M, Brandt, P A V D, Jäger, D, Trautwein, C, Pearson, A T & Luedde, T 2020, ' Pan-cancer image-based detection of clinically actionable genetic alterations ', nature cancer, vol. 1, no. 8, pp. 789–799 . https://doi.org/10.1038/s43018-020-0087-6
Molecular alterations in cancer can cause phenotypic changes in tumor cells and their microenvironment. Routine histopathology tissue slides, which are ubiquitously available, can reflect such morphological changes. Here, we show that deep learning c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5844bb58820a02ee29033be9fcdc522b
https://cris.maastrichtuniversity.nl/en/publications/054bcab0-00a9-4667-b697-9fbf758dba2f
https://cris.maastrichtuniversity.nl/en/publications/054bcab0-00a9-4667-b697-9fbf758dba2f
Autor:
Heike I. Grabsch, Christian Trautwein, Piet A. van den Brandt, Kai A. J. Sommer, Peter Bankhead, Akash Patnaik, Lara R. Heij, Michael Hoffmeister, Tom Luedde, Dirk Jäger, Nadina Ortiz-Brüchle, Hermann Brenner, Andrew Srisuwananukorn, Hannah Sophie Muti, Jefree J. Schulte, Jakob Nikolas Kather, Jan M. Niehues, Jeremias Krause, Amelie Echle, Nicole A. Cipriani, Alexander T. Pearson, Loes F. S. Kooreman, Chiara Loeffler
Precision treatment of cancer relies on genetic alterations which are diagnosed by molecular biology assays.1 These tests can be a bottleneck in oncology workflows because of high turnaround time, tissue usage and costs.2 Here, we show that deep lear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d501b5ca551cd0b57a762bc971decfad
Autor:
Christian Trautwein, Jakob Nikolas Kather, Peter Bankhead, Peter Boor, Andrew Srisuwananukorn, Nishant Agrawal, Jefree J. Schulte, Chiara Loeffler, James M. Dolezal, Takaki Yoshikawa, Saskia von Stillfried, Tom Luedde, Alexander T. Pearson, Heike I. Grabsch, Hannah Sophie Muti, Sara Kochanny, Dirk Jaeger, Nicole A. Cipriani
Oncogenic viruses like human papilloma virus (HPV) or Epstein Barr virus (EBV) are a major cause of human cancer. Viral oncogenesis has a direct impact on treatment decisions because virus-associated tumors can demand a lower intensity of chemotherap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f660f7f68a84fec19580327a2b7129e