Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Chiara Domenicale"'
Autor:
Salvatore Novello, Daniela Mercatelli, Federica Albanese, Chiara Domenicale, Alberto Brugnoli, Elisabetta D'Aversa, Silvia Vantaggiato, Sandra Dovero, Valentina Murtaj, Luca Presotto, Monica Borgatti, Derya R. Shimshek, Erwan Bezard, Rosa Maria Moresco, Sara Belloli, Michele Morari
Publikováno v:
Neurobiology of Disease, Vol 162, Iss , Pp 105579- (2022)
The G2019S mutation of LRRK2 represents a risk factor for idiopathic Parkinson's disease. Here, we investigate whether LRRK2 kinase activity regulates susceptibility to the environmental toxin 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP). G201
Externí odkaz:
https://doaj.org/article/055453400ae74341863a1b9645ff1160
Autor:
Chiara Domenicale, Daniela Mercatelli, Federica Albanese, Salvatore Novello, Fabrizio Vincenzi, Katia Varani, Michele Morari
Publikováno v:
Biomedicines, Vol 10, Iss 4, p 881 (2022)
The G2019S mutation in leucine rich-repeat kinase 2 (LRRK2) is a major cause of familial Parkinson’s disease. We previously reported that G2019S knock-in mice manifest dopamine transporter dysfunction and phosphoSerine129 α-synuclein (pSer129 α-s
Externí odkaz:
https://doaj.org/article/88edc5deace04944ab64ff00ad54ec70
Publikováno v:
Biochemical Society transactions. 50(1)
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with familial and sporadic forms of Parkinson's disease (PD), for which the LRRK2 locus itself represents a risk factor. Idiopathic and LRRK2-related PD share the main clinical