Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Chiara Di Malta"'
Autor:
Nicola Alesi, Damir Khabibullin, Dean M. Rosenthal, Elie W. Akl, Pieter M. Cory, Michel Alchoueiry, Samer Salem, Melissa Daou, William F. Gibbons, Jennifer A. Chen, Long Zhang, Harilaos Filippakis, Laura Graciotti, Caterina Miceli, Jlenia Monfregola, Claudia Vilardo, Manrico Morroni, Chiara Di Malta, Gennaro Napolitano, Andrea Ballabio, Elizabeth P. Henske
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Tuberous Sclerosis Complex (TSC) is caused by TSC1 or TSC2 mutations, leading to hyperactivation of mechanistic target of rapamycin complex 1 (mTORC1) and lesions in multiple organs including lung (lymphangioleiomyomatosis) and kidney (angio
Externí odkaz:
https://doaj.org/article/84551f68541142aa9d79d29bb32f55a5
Autor:
Rossella De Cegli, Diego Carrella, Diletta Siciliano, Gennaro Gambardella, Gennaro Napolitano, Chiara Di Malta, Andrea Ballabio, Diego di Bernardo
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 295-305 (2022)
TFEBexplorer is a comprehensive web-tool to study genes modulated by the transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy, that integrates multiple datasets following genetic perturbation of TFEB with experimen
Externí odkaz:
https://doaj.org/article/b853148c25984783b87dad7ca2b37b7b
Autor:
Xiliang Du, Chiara Di Malta, Zhiyuan Fang, Taiyu Shen, Xiaodi Niu, Meng Chen, Bo Jin, Hao Yu, Lin Lei, Wenwen Gao, Yuxiang Song, Zhe Wang, Chuang Xu, Zhijun Cao, Guowen Liu, Xinwei Li
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 6, Pp 2869-2886 (2022)
Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis and insulin resistance and there are currently no approved drugs for its treatment. Hyperactivation of mTOR complex 1 (mTORC1) and subsequent impairment of the transcripti
Externí odkaz:
https://doaj.org/article/34596150e8264f92a01c724846c248f1
Autor:
Chiara Di Malta, Angela Zampelli, Letizia Granieri, Claudia Vilardo, Rossella De Cegli, Laura Cinque, Edoardo Nusco, Salvatore Pece, Daniela Tosoni, Francesca Sanguedolce, Nicolina Cristina Sorrentino, Maria J Merino, Deborah Nielsen, Ramaprasad Srinivasan, Mark W Ball, Christopher J Ricketts, Cathy D Vocke, Martin Lang, Baktiar Karim, Luisa Lanfrancone, Laura S Schmidt, W Marston Linehan, Andrea Ballabio
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 5, Pp n/a-n/a (2023)
Abstract Birt‐Hogg‐Dubé (BHD) syndrome is an inherited familial cancer syndrome characterized by the development of cutaneous lesions, pulmonary cysts, renal tumors and cysts and caused by loss‐of‐function pathogenic variants in the gene enc
Externí odkaz:
https://doaj.org/article/fc7292bb504a4e85bf4c9b3aa30dc3e3
Autor:
Gennaro Napolitano, Alessandra Esposito, Heejun Choi, Maria Matarese, Valerio Benedetti, Chiara Di Malta, Jlenia Monfregola, Diego Luis Medina, Jennifer Lippincott-Schwartz, Andrea Ballabio
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
On amino acid deprivation TFEB translocates from the cytoplasm to the nucleus. Here the authors identify a nuclear export signal in TFEB that is recognized by the exportin CRM1, and show that dual phosphorylation at S142 and S138 by mTOR accelerates
Externí odkaz:
https://doaj.org/article/0ca34c106f93485d8615cf33135d22a2
Autor:
Chiara Di Malta, Andrea Ballabio
Publikováno v:
Cell Stress, Vol 1, Iss 1, Pp 7-10 (2017)
Externí odkaz:
https://doaj.org/article/6ec1faa30f7249d4b95dab9792816789
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Macro (Autophagy) is a catabolic process that relies on the cooperative function of two organelles: the lysosome and the autophagosome. The recent discovery of a transcriptional gene network that co-regulates the biogenesis and function of these two
Externí odkaz:
https://doaj.org/article/bae7e52f0b5840408a2d362f613f8b4f
Autor:
Yvette Akwa, Chiara Di Malta, Fátima Zallo, Elise Gondard, Adele Lunati, Lara Z. Diaz-de-Grenu, Angela Zampelli, Anne Boiret, Sara Santamaria, Maialen Martinez-Preciado, Katia Cortese, Jeffrey H. Kordower, Carlos Matute, Andres M. Lozano, Estibaliz Capetillo-Zarate, Thomas Vaccari, Carmine Settembre, Etienne E. Baulieu, Davide Tampellini
Publikováno v:
TECNALIA Publications
Fundación Tecnalia Research & Innovation
Fundación Tecnalia Research & Innovation
Synapses represent an important target of Alzheimer disease (AD), and alterations of their excitability are among the earliest changes associated with AD development. Synaptic activation has been shown to be protective in models of AD, and deep brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b560664b3ef223e7a7248c419986b6fe
http://hdl.handle.net/10810/59763
http://hdl.handle.net/10810/59763
Autor:
Duarte C. Barral, Leopoldo Staiano, Cláudia Guimas Almeida, Dan F. Cutler, Emily R. Eden, Clare E. Futter, Antony Galione, André R. A. Marques, Diego Luis Medina, Gennaro Napolitano, Carmine Settembre, Otília V. Vieira, Johannes M. F. G. Aerts, Peace Atakpa‐Adaji, Gemma Bruno, Antonella Capuozzo, Elvira De Leonibus, Chiara Di Malta, Cristina Escrevente, Alessandra Esposito, Paolo Grumati, Michael J. Hall, Rita O. Teodoro, Susana S. Lopes, J. Paul Luzio, Jlenia Monfregola, Sandro Montefusco, Frances M. Platt, Roman Polishchuck, Maria De Risi, Irene Sambri, Chiara Soldati, Miguel C. Seabra
Publikováno v:
Traffic, 23(5), 238-269. WILEY
Funder: Maratona da Saúde
Funder: Royal Society Wolfson
Funder: Wellcome; Id: http://dx.doi.org/10.13039/100010269
Since the discovery of lysosomes more than 70 years ago, much has been learned about the functions of these organelles.
Funder: Royal Society Wolfson
Funder: Wellcome; Id: http://dx.doi.org/10.13039/100010269
Since the discovery of lysosomes more than 70 years ago, much has been learned about the functions of these organelles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee5d231f62a432f3d967c8e877aee060
https://hdl.handle.net/1887/3479665
https://hdl.handle.net/1887/3479665
Autor:
Jlenia Monfregola, Pier Paolo Di Fiore, Maria Matarese, Marcella Cesana, Lukas A. Huber, Angela Zampelli, Salvatore Pece, Giovanni Bertalot, Mariana E. G. de Araujo, Taras Stasyk, Edoardo Nusco, Chiara Di Malta, Diletta Siciliano, Alessandro Venuta, Gennaro Napolitano, Claudia Vilardo, Valerio Benedetti, Alessia Calcagni, Alessandra Esposito, Andrea Ballabio
Publikováno v:
Nature
The mechanistic target of rapamycin complex 1 (mTORC1) is a key metabolic hub that controls the cellular response to environmental cues by exerting its kinase activity on multiple substrates1–3. However, whether mTORC1 responds to diverse stimuli b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c28322620ad4d4c101de6a8925d72cd5
https://doi.org/10.1038/s41586-020-2444-0
https://doi.org/10.1038/s41586-020-2444-0