Výsledky vyhledávání - "Chiara De Pascalis"

Microtubules tune mechanosensitive cell responses

Autor: Stéphane Vassilopoulos, Batiste Boëda, Vanessa Roca, Aaron J. Farrugia, Sandrine Etienne-Manneville, Benoit Vianay, Manuel Théry, Alexander D. Bershadsky, Damarys Loew, Chiara De Pascalis, Shailaja Seetharaman, Florent Dingli

Publikováno v: Nature Materials
Nature Materials, 2021, ⟨10.1038/s41563-021-01108-x⟩
Nature Materials, Nature Publishing Group, 2021, ⟨10.1038/s41563-021-01108-x⟩

International audience; Mechanotransduction is a process by which cells sense the mechanical properties of their surrounding environment and adapt accordingly to perform cellular functions such as adhesion, migration and differentiation. Integrin-med

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65fb9bbcbda4324063826ba746b60848
https://hal-pasteur.archives-ouvertes.fr/pasteur-03096554

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Intermediate filaments control collective migration by restricting traction forces and sustaining cell–cell contacts

Autor: Sandrine Etienne-Manneville, Nicolas Borghi, Mithila Burute, Shailaja Seetharaman, Chiara De Pascalis, Xavier Trepat, Batiste Boëda, Carlos Pérez-González, Cécile Leduc, Benoit Vianay

Publikováno v: The Journal of Cell Biology
Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2018, 217 (9), pp.3031-3044. ⟨10.1083/jcb.201801162⟩
Dipòsit Digital de la UB
Universidad de Barcelona
Journal of Cell Biology 9 (217), 3031-3044. (2018)
Journal of Cell Biology, 2018, 217 (9), pp.3031-3044. ⟨10.1083/jcb.201801162⟩

Using an in vitro wound healing assay, De Pascalis et al. show that intermediate filaments (IFs) participate in the dynamics of the acto-myosin network and its association with adhesions in astrocytes during collective migration. Glial IFs control th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c12ff14c8ddb7d8beb8af38a443b0b
http://europepmc.org/articles/PMC6122997

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Single and collective cell migration: the mechanics of adhesions

Autor: Chiara De Pascalis, Sandrine Etienne-Manneville

Publikováno v: Molecular Biology of the Cell
Molecular Biology of the Cell, 2017, 28 (14), pp.1815-2022. ⟨10.1091/mbc.E17-03-0134⟩
Molecular Biology of the Cell, American Society for Cell Biology, 2017, 28 (14), pp.1815-2022. ⟨10.1091/mbc.E17-03-0134⟩

International audience; Chemical and physical properties of the environment control cell proliferation, differentiation, or apoptosis in the long term. However, to be able to move and migrate through a complex three-dimensional environment, cells mus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ead193837aaefb04a0caa839f2e4425
http://europepmc.org/articles/PMC5541834

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Microtubules tune mechanosensitive cell responses

Autor: Shailaja, Seetharaman, Benoit, Vianay, Vanessa, Roca, Aaron J, Farrugia, Chiara, De Pascalis, Batiste, Boëda, Florent, Dingli, Damarys, Loew, Stéphane, Vassilopoulos, Alexander, Bershadsky, Manuel, Théry, Sandrine, Etienne-Manneville

Publikováno v: Nature materials. 21(3)

Mechanotransduction is a process by which cells sense the mechanical properties of their surrounding environment and adapt accordingly to perform cellular functions such as adhesion, migration and differentiation. Integrin-mediated focal adhesions ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c0125714b8f606c74c49518ad3aa6638
https://pubmed.ncbi.nlm.nih.gov/34663952

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Acto-myosin network geometry defines centrosome position

Autor: Michel Bornens, Ana Joaquina Jimenez, Robert D. Goldman, Chiara De Pascalis, Laurent Blanchoin, Matthieu Piel, Gaëlle Letort, Manuel Théry, Benoit Vianay

Publikováno v: Current Biology-CB
Current Biology-CB, 2021, 31 (6), pp.1206-1220.e5. ⟨10.1016/j.cub.2021.01.002⟩
Current Biology-CB, Elsevier, 2021, 31 (6), pp.1206-1220.e5. ⟨10.1016/j.cub.2021.01.002⟩
Current Biology

International audience; The centrosome is the main organizer of microtubules and as such, its position is a key determinant of polarized cell functions. As the name says, the default position of the centrosome is considered to be the cell geometrical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b645e61aaa41f90c5af99c60a6bb0b9
https://doi.org/10.1016/j.cub.2021.01.002

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Regulation of the microtubular cytoskeleton by Polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration

Autor: Gianfranco Distefano, Letizia Lanzetti, Nadia Ducano, Maddalena Castelli, Amanda Oldani, Alessandra Boletta, Chiara De Pascalis

Publikováno v: BMC Cell Biology

Background Polycystin-1 (PC-1) is a large plasma membrane receptor, encoded by the PKD1 gene, which is mutated in most cases of Autosomal Dominant Polycystic Kidney Disease (ADPKD). The disease is characterized by renal cysts. The precise function of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8cc4bc944ff5606ba602770c22cbbd3
https://pubmed.ncbi.nlm.nih.gov/25947155

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Integrin diversity brings specificity in mechanotransduction

Autor: Seetharaman, Shailaja, Etienne-Manneville, Sandrine

Publikováno v: Biology of the Cell
Biology of the Cell, Wiley, 2018, 110 (3), pp.49-64. ⟨10.1111/boc.201700060⟩
Biology of the Cell, 2018, 110 (3), pp.49-64. ⟨10.1111/boc.201700060⟩

International audience; Cells sense and respond to the biochemical and physical properties of the extracellular matrix (ECM) through adhesive structures that bridge the cell cytoskeleton and the surrounding environment. Integrin-mediated adhesions in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::469b329c7da1d4168f4c91cd1fbdb6e7
https://hal-pasteur.archives-ouvertes.fr/pasteur-02058751

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Intermediate filaments in cell migration and invasion: the unusual suspects

Autor: Cécile Leduc, Sandrine Etienne-Manneville

Publikováno v: Current Opinion in Cell Biology
Current Opinion in Cell Biology, Elsevier, 2015, 32, pp.102-112. ⟨10.1016/j.ceb.2015.01.005⟩
Current Opinion in Cell Biology, 2015, 32, pp.102-112. ⟨10.1016/j.ceb.2015.01.005⟩

International audience; Cell migration is a multistep process which relies on the coordination of cytoskeletal structures in space and time. While the roles of actin and microtubules have been investigated in great details, the lack of inhibitors and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae6978815f52292e1381e2cd4041588a
https://doi.org/10.1016/j.ceb.2015.01.005

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