Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Chiara Chiozzini"'
Autor:
Francesco Manfredi, Chiara Chiozzini, Flavia Ferrantelli, Patrizia Leone, Katherina Pugliese, Massimo Spada, Antonio Di Virgilio, Andrea Giovannelli, Mauro Valeri, Andrea Cara, Zuleika Michelini, Mauro Andreotti, Maurizio Federico
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract Induction of effective immunity in the lungs should be a requisite for any vaccine designed to control the severe pathogenic effects generated by respiratory infectious agents. We recently provided evidence that the generation of endogenous
Externí odkaz:
https://doaj.org/article/eb081687f21442b483c9c02222fd9bdc
Autor:
Flavia Ferrantelli, Francesco Manfredi, Chiara Chiozzini, Patrizia Leone, Katherina Pugliese, Massimo Spada, Antonio Di Virgilio, Andrea Giovannelli, Mauro Valeri, Andrea Cara, Zuleika Michelini, Mauro Andreotti, Maurizio Federico
Publikováno v:
Vaccines, Vol 11, Iss 9, p 1433 (2023)
Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 enters the host by infecting nasal ciliated cells. Then, the virus can spread towards the oropharyngeal cavity and the pulmonary tissues. The antiviral adaptive immunity is promptly induced i
Externí odkaz:
https://doaj.org/article/7d872f04b65d4f41b4649aa68b4a65b0
Autor:
Francesco Manfredi, Chiara Chiozzini, Flavia Ferrantelli, Patrizia Leone, Andrea Giovannelli, Massimo Sanchez, Maurizio Federico
Publikováno v:
Vaccines, Vol 10, Iss 7, p 1060 (2022)
We propose an innovative anti-SARS-CoV-2 immune strategy based on extracellular vesicles (EVs) inducing an anti-SARS-CoV-2 N CD8+ T cytotoxic lymphocyte (CTL) immune response. We previously reported that the SARS-CoV-2 N protein can be uploaded at hi
Externí odkaz:
https://doaj.org/article/27a49e3cb82f43e88afcf14b2be30919
Autor:
María Victoria Medina, Agata D Agostino, Qi Ma, Pilar Eroles, Lucas Cavallin, Chiara Chiozzini, Daiana Sapochnik, Cora Cymeryng, Elizabeth Hyjek, Ethel Cesarman, Julian Naipauer, Enrique A Mesri, Omar A Coso
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1009006 (2020)
Kaposi's sarcoma-associated herpesvirus (KSHV) vGPCR is a constitutively active G protein-coupled receptor that subverts proliferative and inflammatory signaling pathways to induce cell transformation in Kaposi's sarcoma. Cyclooxygenase-2 (COX-2) is
Externí odkaz:
https://doaj.org/article/f5e580b584b8453f930179944d01482b
Autor:
Flavia Ferrantelli, Chiara Chiozzini, Francesco Manfredi, Patrizia Leone, Massimo Spada, Antonio Di Virgilio, Andrea Giovannelli, Massimo Sanchez, Andrea Cara, Zuleika Michelini, Maurizio Federico
Publikováno v:
Viruses, Vol 14, Iss 2, p 329 (2022)
SARS-CoV-2-specific CD8+ T cell immunity is expected to counteract viral variants in both efficient and durable ways. We recently described a way to induce a potent SARS-CoV-2 CD8+ T immune response through the generation of engineered extracellular
Externí odkaz:
https://doaj.org/article/bd34405a3e554f2eb1d238514b8fc0c3
Autor:
Chiara Chiozzini, Francesco Manfredi, Flavia Ferrantelli, Patrizia Leone, Andrea Giovannelli, Eleonora Olivetta, Maurizio Federico
Publikováno v:
Vaccines, Vol 9, Iss 4, p 373 (2021)
Intramuscular injection of DNA vectors expressing the extracellular vesicle (EV)-anchoring protein Nefmut fused at its C-terminus to viral and tumor antigens elicit a potent, effective, and anti-tolerogenic CD8+ T cell immunity against the heterologo
Externí odkaz:
https://doaj.org/article/863f59beec024b64840311d45176b793
Autor:
Flavia Ferrantelli, Chiara Chiozzini, Francesco Manfredi, Andrea Giovannelli, Patrizia Leone, Maurizio Federico
Publikováno v:
Vaccines, Vol 9, Iss 3, p 240 (2021)
Most advanced vaccines against severe acute respiratory syndrome coronavirus (SARS-CoV)-2 are designed to induce antibodies against spike (S) protein. Differently, we developed an original strategy to induce CD8+ T cytotoxic lymphocyte (CTL) immunity
Externí odkaz:
https://doaj.org/article/72125878bdb04ff2b5ec0ad58334154f
Publikováno v:
Pharmaceutics, Vol 12, Iss 6, p 529 (2020)
Neurodegenerative diseases are commonly generated by intracellular accumulation of misfolded/aggregated mutated proteins. These abnormal protein aggregates impair the functions of mitochondria and induce oxidative stress, thereby resulting in neurona
Externí odkaz:
https://doaj.org/article/1be0503dfe5041cd9c667ca0efe90638
Autor:
Chiara Chiozzini, Francesco Manfredi, Claudia Arenaccio, Flavia Ferrantelli, Patrizia Leone, Maurizio Federico
Publikováno v:
Vaccines, Vol 8, Iss 2, p 243 (2020)
We recently described a cytotoxic CD8+ T lymphocyte (CTL) vaccine platform based on the intramuscular (i.m.) injection of DNA eukaryotic vectors expressing antigens of interest fused at the C-terminus of HIV-1 Nefmut, i.e., a functionally defective m
Externí odkaz:
https://doaj.org/article/f85ff67bfc704a5797797e253c9d0c64
Autor:
Paola Di Bonito, Barbara Ridolfi, Sandra Columba-Cabezas, Andrea Giovannelli, Chiara Chiozzini, Francesco Manfredi, Simona Anticoli, Claudia Arenaccio, Maurizio Federico
Publikováno v:
Viruses, Vol 7, Iss 3, Pp 1079-1099 (2015)
We developed an innovative strategy to induce a cytotoxic T cell (CTL) immune response against protein antigens of choice. It relies on the production of exosomes, i.e., nanovesicles spontaneously released by all cell types. We engineered the upload
Externí odkaz:
https://doaj.org/article/1a3fa3d7ba424da29777043d2a888eca