Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Chiara Buono"'
Autor:
François Pognan, Chiara Buono, Philippe Couttet, Jean-René Galarneau, Yoav Timsit, Armin Wolf
Publikováno v:
Current Research in Toxicology, Vol 3, Iss , Pp 100091- (2022)
Sotuletinib (BLZ945), a CSF1-R specific kinase inhibitor developed for the treatment of Amyotrophic Lateral Sclerosis, induced liver enzyme elevation in absence of hepatocellular lesions in preclinical rat and monkey studies. The monocytic cell famil
Externí odkaz:
https://doaj.org/article/dc28d07b7f084f78b022a13a770acd1c
Autor:
Stefan Peukert, Hatice Belgin Gulgeze Efthymiou, Ruowei Mo, Yunshan Peng, Fupeng Ma, Guillaume Barbe, Gregory Bebernitz, Cary Fridrich, Chiara Buono, Eric T. Williams, Thomas Daniels, Lisha Li, Xia Zhang, Yuichiro Adachi, Mie Abe, Andrew K.P. Taggart
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 85:129237
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc79f678c2bfd9c5d56a3a82c1fc764e
https://doi.org/10.1016/j.bmcl.2023.129237
https://doi.org/10.1016/j.bmcl.2023.129237
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 11, Pp 2411-2418 (2007)
Liver X receptors (LXRs) are ligand-activated transcription factors involved in the control of lipid metabolism and inflammation. Several studies have recently shown that LXRs promote reverse cholesterol transport and inhibit atherosclerosis. Our stu
Externí odkaz:
https://doaj.org/article/9f301b13b4a041e0a3214876cf69724c
Autor:
Randall J. Bateman, David Kagan, Keith Mansfield, Neeta Shenoy, Julie Douville, Tim West, Geoffrey G. Goodrich, Randy L. Webb, Marc DeCristofaro, Chiara Buono, Wei Zhou, Frederic Cumin, Chandrassegar Saravanan, Mary S. Holubasch, Philip B. Verghese, Heidi A. Schoenfeld
Publikováno v:
Toxicology and Applied Pharmacology. 323:53-65
Sacubitril/valsartan (LCZ696) is the first angiotensin receptor neprilysin inhibitor approved to reduce cardiovascular mortality and hospitalization in patients with heart failure with reduced ejection fraction. As neprilysin (NEP) is one of several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b41e7e4be08e50b60a23d954de4a52
Autor:
Armin Wolf, Francois Pognan, Nandita Shangari, Lee Anne McLean, Elba Cruz, Parul Patel, Salah-Dine Chibout, Shruthi Sampath, Pierre Moulin, Steve Busch, Chiara Buono, Albert Reising, Maya Gurnani
Publikováno v:
Toxicological Sciences
Toxicological Sciences; Vol 126
Toxicological Sciences; Vol 126
Lens explant cultures were used to assess the mechanism of drug-induced cataractogenic potential of NVS001, a peroxisome proliferator-activated receptor delta (PPARδ) agonist, which resulted in cataract in all treated animals during a 13-week rat st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a2a496909310b2e3e368b2ee6b548c
Publikováno v:
Journal of Clinical Investigation. 119:1373-1381
The uptake of lipoproteins by macrophages is a critical step in the development of atherosclerotic lesions. Cultured monocyte-derived macrophages take up large amounts of native LDL by receptor-independent fluid-phase pinocytosis, either constitutive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22913fe29870312508bdd44971cb72eb
https://doi.org/10.1172/jci35548
https://doi.org/10.1172/jci35548
Autor:
Eric M. Billings, Yifu Li, Stephen W. Waldo, Chiara Buono, Janet Chang, Bin Zhao, Howard S. Kruth
Publikováno v:
The American Journal of Pathology. 172:1112-1126
Research suggests that monocytes differentiate into unique lineage-determined macrophage subpopulations in response to the local cytokine environment. The present study evaluated the atherogenic potential of two divergent lineage-determined human mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8ddb68dae5db7a11da2777bb5dc142
https://doi.org/10.2353/ajpath.2008.070513
https://doi.org/10.2353/ajpath.2008.070513
Autor:
Masahiro Mori, Howard S. Kruth, Bin Zhao, Yifu Li, Stephen W. Waldo, Chiara Buono, Nancy L. Jones
Publikováno v:
Journal of Biological Chemistry. 281:15757-15762
Recently, we have shown that macrophage uptake of low density lipoprotein (LDL) and cholesterol accumulation can occur by nonreceptor mediated fluid-phase macropinocytosis when macrophages are differentiated from human monocytes in human serum and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b909d815b47f2e1158c87c322185a20
https://doi.org/10.1074/jbc.m510714200
https://doi.org/10.1074/jbc.m510714200
Publikováno v:
Circulation. 109:2009-2015
Background—Several lines of evidence indicate that T-cell responses influence the progression of atherosclerotic disease. Interferon-γ (IFN-γ)–producing T cells specific for lesional antigens, including oxidized LDLs and heat shock protein 60 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34dd98abc484810337370eae52bd7c41
https://doi.org/10.1161/01.cir.0000127121.16815.f1
https://doi.org/10.1161/01.cir.0000127121.16815.f1
Autor:
Graham F. Maguire, Chiara Buono, Carolyn E. Come, Andrew H. Lichtman, Philip W. Connelly, George Stavrakis
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 23:454-460
Objective—The aim of this study was to investigate the influence of interferon-γ (IFN-γ) on atherosclerosis in low density lipoprotein receptor (LDLR)–null mice.Methods and Results—We cross-bred IFN-γ–deficient mice with LDLR-null mice and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80622c1355c8b2fc4f274de9901264f8
https://doi.org/10.1161/01.atv.0000059419.11002.6e
https://doi.org/10.1161/01.atv.0000059419.11002.6e