Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Chiara Bardella"'
Autor:
Raphael Reinbold, Ingvild C. Hvinden, Patrick Rabe, Ryan A. Herold, Alina Finch, James Wood, Melissa Morgan, Maximillian Staudt, Ian J. Clifton, Fraser A. Armstrong, James S. O. McCullagh, Jo Redmond, Chiara Bardella, Martine I. Abboud, Christopher J. Schofield
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The development of IDH variant inhibitors is a breakthrough as it is the first time metabolism has been successfully targeted by small molecule drugs in cancer. Here the authors report studies on resistance to the pioneer drug ivosidenib leading to i
Externí odkaz:
https://doaj.org/article/e3e859d6d730417f8d6ec356de38fe1b
Publikováno v:
Cancers, Vol 15, Iss 11, p 2883 (2023)
Altered metabolism is a common feature of many cancers and, in some cases, is a consequence of mutation in metabolic genes, such as the ones involved in the TCA cycle. Isocitrate dehydrogenase (IDH) is mutated in many gliomas and other cancers. Physi
Externí odkaz:
https://doaj.org/article/6a0133fd534a4b4ea05b14f45aa2ece2
Autor:
Kate E.R. Hollinshead, Haydn Munford, Katherine L. Eales, Chiara Bardella, Chunjie Li, Cristina Escribano-Gonzalez, Alpesh Thakker, Yannic Nonnenmacher, Katarina Kluckova, Mark Jeeves, Robert Murren, Federica Cuozzo, Dan Ye, Giulio Laurenti, Wei Zhu, Karsten Hiller, David J. Hodson, Wei Hua, Ian P. Tomlinson, Christian Ludwig, Ying Mao, Daniel A. Tennant
Publikováno v:
Cell Reports, Vol 22, Iss 12, Pp 3107-3114 (2018)
Summary: Since the discovery of mutations in isocitrate dehydrogenase 1 (IDH1) in gliomas and other tumors, significant efforts have been made to gain a deeper understanding of the consequences of this oncogenic mutation. One aspect of the neomorphic
Externí odkaz:
https://doaj.org/article/26706adfa2534c22a56f1079550fabca
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2, p 924 (2021)
Diffuse gliomas are the most frequent brain tumours, representing 75% of all primary malignant brain tumours in adults. Because of their locally aggressive behaviour and the fact that they cannot be cured by current therapies, they represent one of t
Externí odkaz:
https://doaj.org/article/e4eb8beb9c1443bbb61eaecca27d5669
Autor:
Daniel Krell, Mawuelikem Assoku, Malcolm Galloway, Paul Mulholland, Ian Tomlinson, Chiara Bardella
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19868 (2011)
Isocitrate dehydrogenases (IDHs) catalyse oxidative decarboxylation of isocitrate to α-ketoglutarate (α-KG). IDH1 functions in the cytosol and peroxisomes, whereas IDH2 and IDH3 are both localized in the mitochondria. Heterozygous somatic mutations
Externí odkaz:
https://doaj.org/article/110a7a3d3c2c49268ef73504f2b75bcb
Autor:
Maria Flavia Di Renzo, Massimiliano Mazzone, Nadia Coltella, Martina Olivero, Daniela Dettori, Chiara Bardella
Purpose: Advanced ovarian cancers are initially responsive to combinatorial chemotherapy with platinum drugs and taxanes but, in most cases, develop drug resistance. We recently showed that, in vitro, hepatocyte growth factor (HGF) enhances death of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4cfef1cece930f5a7f679daa0881ae
https://doi.org/10.1158/1078-0432.c.6518446
https://doi.org/10.1158/1078-0432.c.6518446
Autor:
Ian Tomlinson, Shazia Irshad, Stefania Segditsas, Chiara Bardella, Tia Mirshahi, Sujata Biswas, Thomas Starkey, Connor Woolley, Lennard Y.W. Lee
Purpose:The molecular events that determine intestinal cell differentiation are poorly understood and it is unclear whether it is primarily a passive event or an active process. It is clinically important to gain a greater understanding of the proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5527632899eac34ae2404213d3c9974f
https://doi.org/10.1158/1078-0432.c.6529032
https://doi.org/10.1158/1078-0432.c.6529032
Autor:
Ian Tomlinson, Shazia Irshad, Stefania Segditsas, Chiara Bardella, Tia Mirshahi, Sujata Biswas, Thomas Starkey, Connor Woolley, Lennard Y.W. Lee
Supplementary Table 1. Differentially expressed genes from colonic crypt tops vs. bottoms of normal individuals (adjusted p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea0aeccbf160beddb08a6404a21b2a9
https://doi.org/10.1158/1078-0432.22475289.v1
https://doi.org/10.1158/1078-0432.22475289.v1
Autor:
Patrick J. Pollard, Ian Tomlinson, Mona El-Bahrawy, Lauri Aaltonen, Virpi Launonen, Michael I. Kotlikoff, Maria Flavia Di Renzo, Chiara Bardella, Barbara Costa, Christopher W. Pugh, Richard Poulsom, Gordon Stamp, Patrick H. Maxwell, Emanuela Volpi, Mohammed Yusuf, Bradley Spencer-Dene, John Griffiths, Helen Troy, Deepa Shukla, Kimberley Howarth, Melroy Miranda, Emine Hatipoglu, Emma Nye, Heli Lehtonen, Sakari Vanharanta, Phil East, Yuen-Li Chung, Violetta Steeples, Julie Adam, Linda O'Flaherty, Houman Ashrafian
Supplementary Figure 2 from Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63279c06787dcbb711a6788a4f91c1ac
https://doi.org/10.1158/0008-5472.22385853
https://doi.org/10.1158/0008-5472.22385853
Autor:
Patrick J. Pollard, Ian Tomlinson, Mona El-Bahrawy, Lauri Aaltonen, Virpi Launonen, Michael I. Kotlikoff, Maria Flavia Di Renzo, Chiara Bardella, Barbara Costa, Christopher W. Pugh, Richard Poulsom, Gordon Stamp, Patrick H. Maxwell, Emanuela Volpi, Mohammed Yusuf, Bradley Spencer-Dene, John Griffiths, Helen Troy, Deepa Shukla, Kimberley Howarth, Melroy Miranda, Emine Hatipoglu, Emma Nye, Heli Lehtonen, Sakari Vanharanta, Phil East, Yuen-Li Chung, Violetta Steeples, Julie Adam, Linda O'Flaherty, Houman Ashrafian
Supplementary Figure 1 from Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d66bd17812622d75cdee182e67af7c11
https://doi.org/10.1158/0008-5472.22385856.v1
https://doi.org/10.1158/0008-5472.22385856.v1