Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Chiara, Sabatini"'
Autor:
Gianfranco Caselli, Albino Bonazzi, Emanuele Sala, Chiara Sabatini, Flora Ferrari, Miriam Borsi Franchini, Chiara Milia, Lucio C. Rovati, Eleonora Comi, Marco Lanza
Publikováno v:
British Journal of Pharmacology
Background and purpose Prolonged use of opioids causes analgesic tolerance and adverse effects including constipation and dependence. Compounds targeting imidazoline I2 receptors are known to potentiate opioid analgesia in rodents. We investigated wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f393eb07c05e2b9bcdef86e302d07d4f
https://pubmed.ncbi.nlm.nih.gov/32154915
https://pubmed.ncbi.nlm.nih.gov/32154915
Autor:
Antonio Gambaro, Giovanni Maria Flora, Giovanni Canzio, Carlotta Conti, Carlo Bonzano, Alessandro Amato, Cecilia Valbonesi, Marco Cattaneo, Daniela Di Bucci, Mauro Dolce, Elvezio Galanti, Nicola Casagli, Federico Falorni, Marco Marchetti, Paola Frati, Emanuela Turillazzi, Vittorio Fineschi, Giuseppe Traversa, Chiara Sabatini, Paolo Terracciano, Andrea Cerase
Autor:
Chiara Sabatini, Lucio C. Rovati, Chiara Giacomoni, Gianfranco Caselli, Ornella Letari, Marco Lanza, Vittorio Vellani, Chiara Milia
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: CR4056 is a first‐in‐class imidazoline‐2 (I(2)) receptor ligand characterized by potent analgesic activity in different experimental animal models of pain. In a recent phase II clinical trial, CR4056 effectively reduced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c22e7e9bd3fe3cfb3f109066cf4c99
https://pubmed.ncbi.nlm.nih.gov/31454418
https://pubmed.ncbi.nlm.nih.gov/31454418
Autor:
Andrea Cappelli, Gianluca Giorgi, Maurizio Anzini, Laura Mennuni, Marco Paolino, Germano Giuliani, Marco Lanza, Gianfranco Caselli, Annalisa Reale, Cinzia Maria Francini, Chiara Sabatini, Federica Castriconi, Giorgio Grisci
Two small series of quinoline derivatives were designed starting from previously published quinoline derivatives 7a and b in order to obtain information about their interaction with the 5-HT(4)R binding site. Initially, the structure of 7a and b was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d6922e480121d3872aa6b5a52d16521
https://europepmc.org/articles/PMC6148519/
https://europepmc.org/articles/PMC6148519/
Autor:
Federica, Castriconi, Marco, Paolino, Alessandro, Donati, Germano, Giuliani, Maurizio, Anzini, Laura, Mennuni, Chiara, Sabatini, Marco, Lanza, Gianfranco, Caselli, Francesco, Makovec, Maria, Sbraccia, Paola, Molinari, Tommaso, Costa, Andrea, Cappelli
Multivalency does not improve the binding and functional activities of ML10302 at 5-HT4 receptors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f2cecbc39613f6395848f8ad2e85b7f9
https://europepmc.org/articles/PMC6071950/
https://europepmc.org/articles/PMC6071950/
Autor:
Marco Paolino, Maurizio Anzini, Laura Mennuni, Paola Molinari, Francesco Makovec, Andrea Cappelli, Federica Castriconi, Maria Sbraccia, Tommaso Costa, Gianfranco Caselli, Chiara Sabatini, Marco Lanza, Alessandro Donati, Germano Giuliani
5-HT4 receptors are known to form constitutive dimers in membranes. To explore whether multivalency can enhance ligand interactions and/or efficacy in 5-HT4 receptors, the structure of the partial agonist ML10302 was modified with oligo(ethylene glyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ecb172b9b08578705cd4704fd92e185
http://hdl.handle.net/11365/1005015
http://hdl.handle.net/11365/1005015
Autor:
Maurizio Anzini, Germano Giuliani, Gianfranco Caselli, Maria Cristina Menziani, Antonio Giordani, Andrea Cappelli, Chiara Sabatini, Marco Paolino, Alessia Chelini, Laura Mennuni, Chiara Nannicini, Francesco Makovec, Gianluca Giorgi, Salvatore Vomero
Two new fluorophenylindenone derivatives were designed as potential p38α MAPK modulators by preserving the key interactions of the vicinal pyridine/fluorophenyl pharmacophore with the enzyme protein. Interestingly, these two fluorophenylindenone iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b3d971c122757490d6f923b3acf13c
http://hdl.handle.net/11365/998341
http://hdl.handle.net/11365/998341
Autor:
Flora Ferrari, Massimo Ubaldi, Chiara Galimberti, Valerio Mammoli, Esi Domi, Laura Mennuni, Marco Lanza, Chiara Milia, Maria Pigini, Fabio Del Bello, Chiara Sabatini, Mario Giannella, Giovanni Caprioli, Eleonora Comi, Massimo Ricciutelli, Gianni Sagratini
Tolerance to opioid administration represents a serious medical alert in different chronic conditions. This study compares the effects of the imidazoline compounds 1, 2, and 3 on morphine tolerance in an animal model of inflammatory pain in the rat.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5da6eda5938891ecd3bdc1e386c5c3f0
http://hdl.handle.net/11581/388683
http://hdl.handle.net/11581/388683
Autor:
Andrea Cappelli, Marco Lanza, Maria Sbraccia, Marco Paolino, Maria Cristina Menziani, Paola Molinari, Gianfranco Caselli, Tommaso Costa, Laura Mennuni, Giuseppe Campiani, Germano Giuliani, Francesca De Rienzo, Federica Castriconi, Maurizio Anzini, Chiara Sabatini
Publikováno v:
European journal of medicinal chemistry. 82
A small series of serotonin 5-HT4 receptor ligands has been designed from flexible 2-methoxyquinoline compounds 7a,b by applying the conformational constraint approach. Ligands 7a,b and the corresponding conformationally constrained analogues 8a-g we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257e5df2be41dc1a35c8851bf04a9d95
https://pubmed.ncbi.nlm.nih.gov/24871995
https://pubmed.ncbi.nlm.nih.gov/24871995