Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Chiara, Pizzo"'
Autor:
Ninfa Vera, Graciela Mahler, Chiara Pizzo, Paula Faral-Tello, Carlos Robello, Cecilia Saiz, Gloria Yaluff, Elva Serna, Susana Torres
Publikováno v:
European Journal of Medicinal Chemistry. 109:107-113
Herein, we describe a new approach towards the synthesis of selenosemicarbazones. The reaction involves an O-Se exchange of semicarbazones using Ishihara reagent. Eleven selenosemicarbazones were prepared using this methodology, with low to moderate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e868b7ace7d4f4f6e43b38621a6958c6
https://doi.org/10.1016/j.ejmech.2015.12.040
https://doi.org/10.1016/j.ejmech.2015.12.040
Autor:
Graciela Mahler, Chiara Pizzo
Publikováno v:
Tetrahedron Letters. 58:1445-1447
In this work we describe the Woollins’ reagent as useful for the selective reduction of the double bond of 2-α,β-unsaturated thiazo and selenazolidinones. The reaction took place in toluene at room temperature to give the corresponding saturated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c24b626968d20409ff30a01227e22b1
https://doi.org/10.1016/j.tetlet.2017.02.053
https://doi.org/10.1016/j.tetlet.2017.02.053
Autor:
Chiara Pizzo, Graciela Mahler
Publikováno v:
The Journal of Organic Chemistry. 79:1856-1860
Herein, we describe an approach toward selenazole preparation based on the cycloisomerization of propargyl selenoamides. The selenoamides were synthesized in situ using the Ishihara reagent with spontaneous cyclization to form the 2,5-disubstituted s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4ddc4bfd0dbec13260db58cccb6135
https://doi.org/10.1021/jo402661b
https://doi.org/10.1021/jo402661b
Autor:
Bruno Demoro, Graciela Mahler, Francesco Caruso, Daniel Liebowitz, Dinorah Gambino, Claudio Olea-Azar, Lucía Otero, Miriam Rossi, Chiara Pizzo, Ulrike Kemmerling, Virtudes Moreno, Helena Guiset, Juan Diego Maya
Publikováno v:
Biological Trace Element Research. 153:371-381
In the search for new metal-based drugs against diseases produced by trypanosomatid parasites, four organoruthenium(II) compounds [Ru2(p-cymene)2(L)2]X2, where L are bioactive 5-nitrofuryl-containing thiosemicarbazones and X = Cl or PF6, had been pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e95f7b6eacfdf3bef46345663e94176
https://doi.org/10.1007/s12011-013-9653-4
https://doi.org/10.1007/s12011-013-9653-4
Autor:
Cecilia Saiz, Graciela Mahler, Agustina Chidichimo, Luis Enrique Bruno Blanch, Alan Talevi, Diego Benítez, Peter Wipf, Pablo Hernán Palestro, Carolina Leticia Bellera, Luciana Gavernet, Chiara Pizzo, Juan José Cazzulo
Publikováno v:
Chemical Biology & Drug Design. 77:166-172
A series of 18 novel 2-hydrazolyl-4-thiazolidinones-5-carboxylic acids, amides and 5,6-α,β-unsaturated esters were synthesized, and their in vitro activity on cruzipain and T. cruzi epimastigotes was determined. Some agents show activity at 37 μm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a745321303bf27d35d13e7e4a386b3fa
https://doi.org/10.1111/j.1747-0285.2010.01071.x
https://doi.org/10.1111/j.1747-0285.2010.01071.x
Publikováno v:
Tetrahedron Letters. 50:6810-6813
Microwave irradiation facilitated the synthesis of 4-arylthio-3-oxazolin-5-ones from ethyl cyanoformate, thiophenol, and cyclic ketones. Subsequent decarboxylation and in situ [3+2] cycloaddition provided novel 2,3,4,5-tetrahydro-1H-pyrrolo[1,2-c][1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf2efc28d989fa7c5463da5d3becf74
https://doi.org/10.1016/j.tetlet.2009.09.107
https://doi.org/10.1016/j.tetlet.2009.09.107
Autor:
Graciela Mahler, Chiara Pizzo
Publikováno v:
ChemInform. 45
The title heterocycles are synthesized from readily available starting materials including a wide range of aryl and alkyl substituents.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48c2ab2b1181ce3f38566443380533a8
https://doi.org/10.1002/chin.201431194
https://doi.org/10.1002/chin.201431194
Autor:
Chiara Pizzo, Graciela Mahler
Publikováno v:
Proceedings of the 15th Brazilian Meeting on Organic Synthesis Proceedings.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99c09a2128c0c7f4d5a068e7b995ce2d
https://doi.org/10.5151/chempro-15bmos-bmos2013_2013819141440
https://doi.org/10.5151/chempro-15bmos-bmos2013_2013819141440
Publikováno v:
Proceedings of the 14th Brazilian Meeting on Organic Synthesis Proceedings.
Cruzipain is the native enzyme responsible for the mayor proteolytic activity in all stages of Trypanosoma cruzi parasite, the causative agent of Chagas disease. 3 Thiosemicarbazones have been developed as reversible cruzipain inhibitors. 4 In this o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24df112785956db0264fd78b6b07cfd0
https://doi.org/10.5151/chempro-14bmos-r0067-1
https://doi.org/10.5151/chempro-14bmos-r0067-1
Autor:
Chiara, Pizzo, Cecilia, Saiz, Alan, Talevi, Luciana, Gavernet, Pablo, Palestro, Carolina, Bellera, Luis Bruno, Blanch, Diego, Benítez, Juan J, Cazzulo, Agustina, Chidichimo, Peter, Wipf, S Graciela, Mahler
Publikováno v:
Chemical biologydrug design. 77(3)
A series of 18 novel 2-hydrazolyl-4-thiazolidinones-5-carboxylic acids, amides and 5,6-α,β-unsaturated esters were synthesized, and their in vitro activity on cruzipain and T. cruzi epimastigotes was determined. Some agents show activity at 37 μm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2419e6ddfe3a4f3b2cf15bd3dcaaa468
https://pubmed.ncbi.nlm.nih.gov/21251233
https://pubmed.ncbi.nlm.nih.gov/21251233