A high-fat and fructose diet in dogs mirrors insulin resistance and β-cell dysfunction characteristic of impaired glucose tolerance in humans.

Autor: Justin M Gregory, Guillaume Kraft, Chiara Dalla Man, James C Slaughter, Melanie F Scott, Jon R Hastings, Dale S Edgerton, Mary C Moore, Alan D Cherrington

Publikováno v: PLoS ONE, Vol 18, Iss 12, p e0296400 (2023)

This study examined the impact of a hypercaloric high-fat high-fructose diet (HFFD) in dogs as a potential model for human impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM). The HFFD not only led to weight gain but also triggered m

Externí odkaz: https://doaj.org/article/b4efcee09ef24e3d9b97e56324454927

Study protocol for a randomised, double-blind, placebo-controlled crossover trial assessing the impact of the SGLT2 inhibitor empagliflozin on postprandial hypoglycaemia after gastric bypass

Autor: António Ferreira, Andrea Facchinetti, Lia Bally, Christos T Nakas, Ahmed Fahiem Abdelsalam Emara, David Herzig, Andreas Melmer, Andreas P Vogt, Chiara Dalla Man

Publikováno v: BMJ Open, Vol 12, Iss 9 (2022)

Introduction Postprandial hypoglycaemia after gastric bypass surgery (also known as postbariatric hypoglycaemia or PBH) is an increasingly encountered clinical problem. PBH is characterised by meal-induced rapid spikes and consequent falls in glycaem

Externí odkaz: https://doaj.org/article/f7648e92b3f7485abf5ca790c43fac6a

Unraveling, contributing factors to the severity of postprandial hypoglycemia after gastric bypass surgery

Autor: David Herzig, Michele Schiavon, Afroditi Tripyla, Vera Lehmann, Jasmin Meier, Sjaam Jainandunsing, Christina Kuenzli, Thomas P. Stauffer, Chiara Dalla Man, Lia Bally

Publikováno v: Herzig, David; Schiavon, Michele; Tripyla, Afroditi; Lehmann, Vera; Meier, Jasmin; Jainandunsing, Sjaam; Kuenzli, Christina; Stauffer, Thomas P; Dalla Man, Chiara; Bally, Lia (2023). Unraveling, contributing factors to the severity of postprandial hypoglycemia after gastric bypass surgery. Surgery for obesity and related diseases, 19(5), pp. 467-472. Elsevier 10.1016/j.soard.2022.10.037

BACKGROUND Despite the increasing prevalence of postbariatric hypoglycemia (PBH), a late metabolic complication of bariatric surgery, our understanding of its diverse manifestations remains incomplete. OBJECTIVES To contrast parameters of glucose-ins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5654d82e4c4d8c2006b9550ff5206d72
https://doi.org/10.1016/j.soard.2022.10.037

Model-Based Assessment of C-Peptide Secretion and Kinetics in Post Gastric Bypass Individuals Experiencing Postprandial Hyperinsulinemic Hypoglycemia

Autor: Michele Schiavon, David Herzig, Matthias Hepprich, Marc Y. Donath, Lia Bally, Chiara Dalla Man

Publikováno v: Frontiers in Endocrinology, Vol 12 (2021)

Assessment of insulin secretion is key to diagnose postprandial hyperinsulinemic hypoglycemia (PHH), an increasingly recognized complication following bariatric surgery. To this end, the Oral C-peptide Minimal Model (OCMM) can be used. This usually r

Externí odkaz: https://doaj.org/article/f23c1dc0ff6745688a33c17d0755b2f7

The Effect of Diabetes-Associated Variation in

Autor: Jon D, Adams, Aoife M, Egan, Marcello C, Laurenti, Daniel, Schembri Wismayer, Kent R, Bailey, Claudio, Cobelli, Chiara, Dalla Man, Adrian, Vella

Publikováno v: Metabolic syndrome and related disorders. 20(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c7c9b5b05d2abbca4c86621c427fe603
https://pubmed.ncbi.nlm.nih.gov/35442800