Výsledky vyhledávání - "Chiara, Battelli"

Expression and function of ABCG2 and XIAP in glioblastomas

Autor: Jeffrey E. Florman, Hagen Blaszyk, Kyuson Yun, Kin-Hoe Chow, Ivette F. Emery, Stephanie Wood, Joshy George, Archana Gopalan, Chiara Battelli

Publikováno v: Journal of Neuro-Oncology. 133:47-57

Despite multimodal treatment that includes surgery, radiation and chemotherapy, virtually all glioblastomas (GBM) recur, indicating that these interventions are insufficient to eradicate all malignant cells. To identify potential new therapeutic targ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e5f87eb98d2cc87e13a0845e6e6df27
https://doi.org/10.1007/s11060-017-2422-z

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Frequency of mutations in individuals with breast cancer referred forBRCA1andBRCA2testing using next-generation sequencing with a 25-gene panel

Autor: Kristin Sedgwick, Kirsten Timms, Benjamin B. Roa, Nadine Tung, Richard J. Wenstrup, Anne-Renee Hartman, Brian Allen, Judy Garber, Kathleen A. Soltis, Leif W. Ellisen, Jill Krejdovsky, Christina I. Herold, Chiara Battelli, Kim DeLeonardis, Satish Bhatnagar, Karla R. Bowles, Rajesh R. Kaldate

Publikováno v: Cancer. 121:25-33

BACKGROUND Next-generation sequencing (NGS) allows for simultaneous sequencing of multiple cancer susceptibility genes and, for an individual, may be more efficient and less expensive than sequential testing. The authors assessed the frequency of del

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6467372be16c4bd5357faaffe1605274
https://doi.org/10.1002/cncr.29010

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Sublethal concentrations of 17-AAG suppress homologous recombination DNA repair and enhance sensitivity to carboplatin and olaparib in HR proficient ovarian cancer cells

Autor: Panagiotis A. Konstantinopoulos, Chiara Battelli, Ursula A. Matulonis, Jennifer Curtis, Jacqueline Watson, Alexander Morse, Dipanjan Chowdhury, Joyce F. Liu, Young Eun Choi

Publikováno v: Oncotarget

// Young Eun Choi 1 , Chiara Battelli 2 , Jacqueline Watson 1 , Joyce Liu 3 , Jennifer Curtis 3 , Alexander N. Morse 4 , Ursula A. Matulonis 3 , Dipanjan Chowdhury 1 , Panagiotis A. Konstantinopoulos 1, 3 1 Department of Radiation Oncology, Dana Farb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299e0c9de81d17633d1db4880319cf24
https://doi.org/10.18632/oncotarget.1929

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Abstract PD4-8: Prevalence of gene mutations among hereditary breast and ovarian cancer patients using a 25 gene panel

Autor: R Kaldate, S Bhatnagar, Kirsten Timms, Benjamin B. Roa, Richard J. Wenstrup, Nadine Tung, K Bowles, A-R Hartman, K Soltis, Chiara Battelli, Brian C. Allen

Publikováno v: Cancer Research. 73:PD4-8

Identifying individuals at increased risk for hereditary cancer leads to early detection and prevention opportunities with the ability to reduce both cancer incidence and mortality. Hereditary cancer syndromes have genetic heterogeneity and new susce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::683983ede81cf0c281066facfbdf1901
https://doi.org/10.1158/0008-5472.sabcs13-pd4-8

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Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Science translational medicine 8 (2016): 350ra104. doi:10.1126/scitranslmed.aad6066
info:cnr-pdr/source/autori:Yong K.J.; Basseres D.S.; Welner R.S.; Zhang W.C.; Yang H.; Yan B.; Alberich-Jorda M.; Zhang J.; De Figueiredo-Pontes L.L.; Battelli C.; Hetherington C.J.; Ye M.; Zhang H.; Maroni G.; O'Brien K.; Magli M.C.; Borczuk A.C.; Varticovski L.; Kocher O.; Zhang P.; Moon Y.-C.; Sydorenko N.; Cao L.; Davis T.W.; Thakkar B.M.; Soo R.A.; Iwama A.; Lim B.; Halmos B.; Neuberg D.; Tenen D.G.; Levantini E./titolo:Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPa expression/doi:10.1126%2Fscitranslmed.aad6066/rivista:Science translational medicine/anno:2016/pagina_da:350ra104/pagina_a:/intervallo_pagine:350ra104/volume:8
Sci Transl Med

Lung cancer is the most common cause of cancer deaths. The expression of the transcription factor C/EBPα (CCAAT/enhancer binding protein α) is frequently lost in non-small cell lung cancer, but the mechanisms by which C/EBPα suppresses tumor forma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60ee0d58b50b838990060c366b354ae
https://doi.org/10.1126/scitranslmed.aad6066

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Weekly Gemcitabine and 24-Hour Infusional 5-Fluorouracil in Advanced Pancreatic Cancer: A Phase I–II Study

Autor: Giovanni Schinzari, Michele Basso, Carmelo Pozzo, C. Barone, Domenico Corsi, Michela Quirino, Chiara Battelli, Alessandra Cassano, Raffaele Longo

Publikováno v: Oncology. 64:139-145

Objective: In this phase I–II study we explored the potential of the combination of weekly gemcitabine (GEM) and 24-hour continuous infusion of 5-fluorouracil (5-FU) in order to determine the toxicity profile in pancreatic cancer. The efficacy of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e32f5e8351f04e952220eed7daed4be7
https://doi.org/10.1159/000067775

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Frequency of mutations in individuals with breast cancer referred for BRCA1 and BRCA2 testing using next-generation sequencing with a 25-gene panel

Autor: Nadine, Tung, Chiara, Battelli, Brian, Allen, Rajesh, Kaldate, Satish, Bhatnagar, Karla, Bowles, Kirsten, Timms, Judy E, Garber, Christina, Herold, Leif, Ellisen, Jill, Krejdovsky, Kim, DeLeonardis, Kristin, Sedgwick, Kathleen, Soltis, Benjamin, Roa, Richard J, Wenstrup, Anne-Renee, Hartman

Publikováno v: Cancer. 121(1)

Next-generation sequencing (NGS) allows for simultaneous sequencing of multiple cancer susceptibility genes and, for an individual, may be more efficient and less expensive than sequential testing. The authors assessed the frequency of deleterious ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a7e69fa73e10243c274bc4937bcf3f28
https://pubmed.ncbi.nlm.nih.gov/25186627

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Safety and outcome of patients treated with a modified outpatient intraperitoneal regimen for epithelial ovarian, primary peritoneal or fallopian tube cancer

Autor: Chiara Battelli, Panagiotis A. Konstantinopoulos, Christopher S. Awtrey, Mary K. Buss, Meghan Campo

Publikováno v: Chemotherapy. 59(4)

Background: Despite the survival benefit of intraperitoneal (IP) chemotherapy observed in GOG172, significant toxicity and poor treatment completion rates have prevented the widespread acceptance of this regimen. Here, we report our experience with a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c49edb130ff46e379a4f3e862a32f2
https://pubmed.ncbi.nlm.nih.gov/24457572

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mTOR inhibitors in renal cell carcinoma

Autor: Daniel C Cho, Chiara Battelli

The mammalian target of rapamycin (mTOR) is a downstream effector of the PI3-K/Akt/mTOR pathway. Allosteric inhibitors of mTOR, everolimus and temsirolimus, have shown promising clinical activity in advanced renal cell carcinoma but their effect is f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df00a5585608ade6b9e34384ba0ee71
https://europepmc.org/articles/PMC3164983/

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