Expression and function of ABCG2 and XIAP in glioblastomas

Autor: Jeffrey E. Florman, Hagen Blaszyk, Kyuson Yun, Kin-Hoe Chow, Ivette F. Emery, Stephanie Wood, Joshy George, Archana Gopalan, Chiara Battelli

Publikováno v: Journal of Neuro-Oncology. 133:47-57

Despite multimodal treatment that includes surgery, radiation and chemotherapy, virtually all glioblastomas (GBM) recur, indicating that these interventions are insufficient to eradicate all malignant cells. To identify potential new therapeutic targ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e5f87eb98d2cc87e13a0845e6e6df27
https://doi.org/10.1007/s11060-017-2422-z

Frequency of mutations in individuals with breast cancer referred forBRCA1andBRCA2testing using next-generation sequencing with a 25-gene panel

Autor: Kristin Sedgwick, Kirsten Timms, Benjamin B. Roa, Nadine Tung, Richard J. Wenstrup, Anne-Renee Hartman, Brian Allen, Judy Garber, Kathleen A. Soltis, Leif W. Ellisen, Jill Krejdovsky, Christina I. Herold, Chiara Battelli, Kim DeLeonardis, Satish Bhatnagar, Karla R. Bowles, Rajesh R. Kaldate

Publikováno v: Cancer. 121:25-33

BACKGROUND Next-generation sequencing (NGS) allows for simultaneous sequencing of multiple cancer susceptibility genes and, for an individual, may be more efficient and less expensive than sequential testing. The authors assessed the frequency of del

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6467372be16c4bd5357faaffe1605274
https://doi.org/10.1002/cncr.29010

Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression

Autor: Pu Zhang, Atsushi Iwama, Meritxell Alberich-Jorda, Maria Cristina Magli, Junyan Zhang, Daniel G. Tenen, Christopher J. Hetherington, Henry Yang, Min Ye, Daniela S. Basseres, Thomas W. Davis, Kol Jia Yong, Elena Levantini, Lorena Lobo de Figueiredo-Pontes, Bing Lim, Alain C. Borczuk, Hong Zhang, Giorgia Maroni, Ross A. Soo, Wen Cai Zhang, Benedict Yan, Balazs Halmos, Liangxian Cao, Donna Neuberg, Nadiya Sydorenko, Robert S. Welner, Olivier Kocher, Young Choon Moon, Chiara Battelli, Karen B. O'Brien, Lyuba Varticovski, Bhavin Thakkar

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Science translational medicine 8 (2016): 350ra104. doi:10.1126/scitranslmed.aad6066
info:cnr-pdr/source/autori:Yong K.J.; Basseres D.S.; Welner R.S.; Zhang W.C.; Yang H.; Yan B.; Alberich-Jorda M.; Zhang J.; De Figueiredo-Pontes L.L.; Battelli C.; Hetherington C.J.; Ye M.; Zhang H.; Maroni G.; O'Brien K.; Magli M.C.; Borczuk A.C.; Varticovski L.; Kocher O.; Zhang P.; Moon Y.-C.; Sydorenko N.; Cao L.; Davis T.W.; Thakkar B.M.; Soo R.A.; Iwama A.; Lim B.; Halmos B.; Neuberg D.; Tenen D.G.; Levantini E./titolo:Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPa expression/doi:10.1126%2Fscitranslmed.aad6066/rivista:Science translational medicine/anno:2016/pagina_da:350ra104/pagina_a:/intervallo_pagine:350ra104/volume:8
Sci Transl Med

Lung cancer is the most common cause of cancer deaths. The expression of the transcription factor C/EBPα (CCAAT/enhancer binding protein α) is frequently lost in non-small cell lung cancer, but the mechanisms by which C/EBPα suppresses tumor forma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60ee0d58b50b838990060c366b354ae
https://doi.org/10.1126/scitranslmed.aad6066

Frequency of mutations in individuals with breast cancer referred for BRCA1 and BRCA2 testing using next-generation sequencing with a 25-gene panel

Autor: Nadine, Tung, Chiara, Battelli, Brian, Allen, Rajesh, Kaldate, Satish, Bhatnagar, Karla, Bowles, Kirsten, Timms, Judy E, Garber, Christina, Herold, Leif, Ellisen, Jill, Krejdovsky, Kim, DeLeonardis, Kristin, Sedgwick, Kathleen, Soltis, Benjamin, Roa, Richard J, Wenstrup, Anne-Renee, Hartman

Publikováno v: Cancer. 121(1)

Next-generation sequencing (NGS) allows for simultaneous sequencing of multiple cancer susceptibility genes and, for an individual, may be more efficient and less expensive than sequential testing. The authors assessed the frequency of deleterious ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a7e69fa73e10243c274bc4937bcf3f28
https://pubmed.ncbi.nlm.nih.gov/25186627

mTOR inhibitors in renal cell carcinoma

Autor: Daniel C Cho, Chiara Battelli

The mammalian target of rapamycin (mTOR) is a downstream effector of the PI3-K/Akt/mTOR pathway. Allosteric inhibitors of mTOR, everolimus and temsirolimus, have shown promising clinical activity in advanced renal cell carcinoma but their effect is f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df00a5585608ade6b9e34384ba0ee71
https://europepmc.org/articles/PMC3164983/