Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Chiao Guo"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-6 (2022)
Abstract Sickle cell disease (SCD) is associated with altered plasma and erythrocyte lipid profiles. In a previous study, SCD mice with deficiency of proprotein convertase subtilisin/kexin type 9 (PCSK9) were observed to have more severe anemia and i
Externí odkaz:
https://doaj.org/article/61f53a66d1a84a25a1e99ca2232bbd58
Autor:
Jintao Wang, Jessica Venugopal, Paul Silaghi, Enming J Su, Chiao Guo, Daniel A Lawrence, Daniel T Eitzman
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0285499 (2023)
Traumatic brain injury (TBI) is associated with cardiovascular mortality in humans. Enhanced sympathetic activity following TBI may contribute to accelerated atherosclerosis. The effect of beta1-adrenergic receptor blockade on atherosclerosis progres
Externí odkaz:
https://doaj.org/article/b010c65e898940afa1eee0af8a32d7c5
Publikováno v:
Haematologica, Vol 106, Iss 9 (2020)
Sickle cell disease (SCD) is associated with chronic hemolytic anemia and a heightened inflammatory state. The causal role of inflammatory pathways in stroke associated with SCD is unclear. Therefore, the hypothesis that deletion of the non-hematopoi
Externí odkaz:
https://doaj.org/article/547feecea62b4fd792bd7aa27b90af9b
Autor:
Hui Wang, Qian Wang, Jintao Wang, Chiao Guo, Kyle Kleiman, He Meng, Jason S. Knight, Daniel T. Eitzman
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract The effect of lipid lowering on the incidence of deep venous thrombosis (DVT) is controversial. The purpose of this study was to determine the effect of proprotein convertase subtilisin/kexin type 9 (PCSK9) deficiency on development of DVT i
Externí odkaz:
https://doaj.org/article/a1651225529d469ab56256b91b18919b
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
Abstract Some studies have shown that levels of MicroRNA (miR)-223 derived from platelets in the plasma are reduced following inhibition of platelet function, while others have shown a correlation between low plasma miR-223 and high on-treatment plat
Externí odkaz:
https://doaj.org/article/f245dceee28f4925af6d13a8eacd439a
Autor:
Jintao Wang, Hui Wang, Chiao Guo, Wei Luo, Alyssa Lawler, Aswin Reddy, Julia Wang, Eddy B Sun, Daniel T Eitzman
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90146 (2014)
Mebendazole is an antihelminthic drug that exerts its effects via interference with microtubule function in parasites. To determine the utility of mebendazole as a potential treatment for vascular diseases involving proliferation of vascular smooth m
Externí odkaz:
https://doaj.org/article/2248fa92cbe344969285a31796abf244
Publikováno v:
British Journal of Haematology. 196:1040-1051
Sickle cell disease (SCD) is associated with haemolytic anaemia and secondary activation of leucocytes and platelets, which in turn may further exacerbate haemolysis. As cytokine signalling pathways may participate in this cycle, the present study in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b923040966b238ece9a639b29c4cf94
https://doi.org/10.1111/bjh.17941
https://doi.org/10.1111/bjh.17941
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Scientific Reports
Scientific Reports
Proprotein convertase subtilisin/kexin type 9 (PCSK9) deficiency leads to lower cholesterol and is associated with reduced vascular complications in the general population. Cholesterol lowering may also have beneficial effects in sickle cell disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f857dea55900c075235678e0424574
http://link.springer.com/article/10.1038/s41598-020-73463-9
http://link.springer.com/article/10.1038/s41598-020-73463-9
Publikováno v:
Haematologica
Sickle cell disease (SCD) is associated with chronic hemolytic anemia and a heightened inflammatory state. The causal role of inflammatory pathways in stroke associated with SCD is unclear. Therefore, the hypothesis that deletion of the non-hematopoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf10db552dfedf02c5ceb2470594ad03
https://doi.org/10.3324/haematol.2020.252395
https://doi.org/10.3324/haematol.2020.252395
Autor:
Jessica Venugopal, Yanbo Fan, Y. Eugene Chen, Yifang Sun, Chiao Guo, Daniel T. Eitzman, Jianping Li, Gong Yanjun, Haoming Zhang
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: Clopidogrel is a commonly used P2Y 12 inhibitor to treat and prevent arterial thrombotic events. Clopidogrel is a prodrug that requires bioactivation by CYP (cytochrome P450) enzymes to exert antiplatelet activity. Diabetes mellitus is ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c31fa5d010ae7d18830ccb401e5e150
https://doi.org/10.1161/atvbaha.120.314146
https://doi.org/10.1161/atvbaha.120.314146