Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Chiaki Tsuge Ishida"'
Autor:
Trang Thi Thu Nguyen, Chiaki Tsuge Ishida, Enyuan Shang, Chang Shu, Consuelo Torrini, Yiru Zhang, Elena Bianchetti, Maria J Sanchez‐Quintero, Giulio Kleiner, Catarina M Quinzii, Mike‐Andrew Westhoff, Georg Karpel‐Massler, Peter Canoll, Markus D Siegelin
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 10, Pp 1-20 (2019)
Abstract Liver‐X‐receptor (LXR) agonists are known to bear anti‐tumor activity. However, their efficacy is limited and additional insights regarding the underlying mechanism are necessary. By performing transcriptome analysis coupled with globa
Externí odkaz:
https://doaj.org/article/34407949ed7c4e12861f0104f22e7368
Autor:
Enyuan Shang, Yiru Zhang, Chang Shu, Chiaki Tsuge Ishida, Elena Bianchetti, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D. Siegelin
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract XPO1 has recently emerged as a viable treatment target for solid malignancies, including glioblastoma (GBM), the most common primary malignant brain tumor in adults. However, given that tumors become commonly resistant to single treatments,
Externí odkaz:
https://doaj.org/article/ba23ac173ed440d99429cc6ecf60572d
Autor:
Yiru Zhang, Chiaki Tsuge Ishida, Chang Shu, Giulio Kleiner, Maria J. Sanchez-Quintero, Elena Bianchetti, Catarina M. Quinzii, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D. Siegelin
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract Recent data suggest that glioblastomas (GBM) activate the c-MET signaling pathway and display increased levels in anti-apoptotic Bcl-2 family members. Therefore, targeting these two deregulated pathways for therapy might yield synergistic tr
Externí odkaz:
https://doaj.org/article/c7b64c32e50d4b209c3d47ac8b498b63
Autor:
Georg Karpel-Massler, Chiaki Tsuge Ishida, Elena Bianchetti, Yiru Zhang, Chang Shu, Takashi Tsujiuchi, Matei A. Banu, Franklin Garcia, Kevin A. Roth, Jeffrey N. Bruce, Peter Canoll, Markus D. Siegelin
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Glioblastoma (GBM) cells are often characterized by the presence of the IDH1 R132H mutation and high expression of anti-apoptotic proteins. Here, the authors show that the inhibition of Bcl-xL is synthetically lethal in IDH1-mutated GBM models and th
Externí odkaz:
https://doaj.org/article/0f3f4c1834e24518860d56a1a35c45d4
Autor:
Markus D. Siegelin, Dario C. Altieri, Peter Canoll, Jeffrey N. Bruce, Kevin A. Roth, Matei Banu, Basil Horst, Rolando Perez-Lorenzo, Chang Shu, Elena Bianchetti, Chiaki Tsuge Ishida, Georg Karpel-Massler
Suppl. fig. 1: Patient derived-xenograft cells are susceptible to the combination treatment of Gamitrinib and clinically validated BH3-mimetics; Suppl. fig. 2: Transgenically-derived murine glioblastoma cells are susceptible to the combination treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7934e6b98da9d8758ff782ff6178804b
https://doi.org/10.1158/0008-5472.22413665
https://doi.org/10.1158/0008-5472.22413665
Autor:
Markus D. Siegelin, Dario C. Altieri, Peter Canoll, Jeffrey N. Bruce, Kevin A. Roth, Matei Banu, Basil Horst, Rolando Perez-Lorenzo, Chang Shu, Elena Bianchetti, Chiaki Tsuge Ishida, Georg Karpel-Massler
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a610144b288a24bafb556f6d350d300
https://doi.org/10.1158/0008-5472.22413662.v1
https://doi.org/10.1158/0008-5472.22413662.v1
Autor:
Markus D. Siegelin, Peter Canoll, Georg Karpel-Massler, Mike-Andrew Westhoff, Catarina M. Quinzii, Maria J. Sanchez-Quintero, Giulio Kleiner, Elena Bianchetti, Chang Shu, Junfei Zhao, Sheng-Fu L. Lo, Wataru Ishida, Chiaki Tsuge Ishida, Yiru Zhang
Purpose: Glioblastoma remains a challenge in oncology, in part due to tumor heterogeneity.Experimental Design: Patient-derived xenograft and stem-like glioblastoma cells were used as the primary model systems.Results: Based on a transcriptome and sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14156097234a9ce61d44092209fa71b7
https://doi.org/10.1158/1078-0432.c.6528969.v1
https://doi.org/10.1158/1078-0432.c.6528969.v1
Autor:
Markus D. Siegelin, Peter Canoll, Georg Karpel-Massler, Mike-Andrew Westhoff, Catarina M. Quinzii, Maria J. Sanchez-Quintero, Giulio Kleiner, Elena Bianchetti, Chang Shu, Junfei Zhao, Sheng-Fu L. Lo, Wataru Ishida, Chiaki Tsuge Ishida, Yiru Zhang
Supplementary Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455509f6f2fb3a456aacdb303efa1473
https://doi.org/10.1158/1078-0432.22475013
https://doi.org/10.1158/1078-0432.22475013
Autor:
Markus D. Siegelin, Dario C. Altieri, Peter Canoll, Jeffrey N. Bruce, Kevin A. Roth, Matei Banu, Basil Horst, Rolando Perez-Lorenzo, Chang Shu, Elena Bianchetti, Chiaki Tsuge Ishida, Georg Karpel-Massler
Supplementary Figures and Tables: Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230ff489c56181cc5964732e3eb95de2
https://doi.org/10.1158/0008-5472.22413668.v1
https://doi.org/10.1158/0008-5472.22413668.v1
Autor:
Markus D. Siegelin, Dario C. Altieri, Peter Canoll, Jeffrey N. Bruce, Kevin A. Roth, Matei Banu, Basil Horst, Rolando Perez-Lorenzo, Chang Shu, Elena Bianchetti, Chiaki Tsuge Ishida, Georg Karpel-Massler
Rational therapeutic approaches based on synthetic lethality may improve cancer management. On the basis of a high-throughput drug screen, we provide preclinical proof of concept that targeting the mitochondrial Hsp90 chaperone network (mtHsp90) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8e1fb8fd987b1d9c70cab2109f372fa
https://doi.org/10.1158/0008-5472.c.6508784.v1
https://doi.org/10.1158/0008-5472.c.6508784.v1