Výsledky vyhledávání - "Chiaki Tashiro"

Comparative expression analysis uncovers novel features of endogenous antisense transcription

Autor: Naoyuki Yamamoto, Chiaki Tashiro, Kazufumi Watanabe, Rieko Ikeda, Yuki Okada, Hidenori Kiyosawa, Hajime Nakaoka, Koji Numata, Akio Kanai, Kuniya Abe, Rintaro Saito, Kazue Okubo, Masaru Tomita

Publikováno v: Human Molecular Genetics. 17:1631-1640

Increasing numbers of sense-antisense transcripts (SATs), which are transcribed from the same chromosomal location but in opposite directions, have been identified in various eukaryotic species, but the biological meanings of most SATs remain unclear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4696f0795c6d627f67e48db80f04dd
https://doi.org/10.1093/hmg/ddn051

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Syntheses and Biological Activities of Optical Isomers of 3-Chloro-5-(3-(2-oxo-1,2,3,5,6,7,8,8a-octahydroimidazo(1,2-a)pyridine-3-spiro-4'-piperidino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine (Mosapramine1)) Dihydrochloride

Autor: Shinro Setoguchi, Takemi Fukuda, Nobuhiro Marubayashi, Chiaki Tashiro

Publikováno v: Chemical and Pharmaceutical Bulletin. 41:1074-1078

Mosapramine (1) is a new neuroleptic drug with an asymmetric carbon atom (8a) in its imidazopyridine ring. The enantiomers of this agent were synthesized to compare their biological activities, such as antiapomorphine activity, affinity for dopamine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3317a9e87005a8a729e9d0f6c4f5ef35
https://doi.org/10.1248/cpb.41.1074

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Synthesis of Metabolites of Mosapramine. II. Synthesis of Phenolic Metabolites of Mosapramine and Their Pharmacological Activities

Autor: Chiaki Tashiro, Takemi Fukuda, Syuji Yuasa

Publikováno v: YAKUGAKU ZASSHI. 112:615-621

Four phenolic metabolites of (+-)-3-chloro-5-[3-(2-oxo-1,2,3,5,6,7,8,8a-octahydroimidazo[1,2- a]pyridine-3-spiro-4'-piperidino)propyl]-10,11-dihydro-5H-dibenz [b,f]azepine (mosapramine), a new antipsychotic drug, were synthesized in order to determin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f60e6132c3ae7fc9d493b39ece41d610
https://doi.org/10.1248/yakushi1947.112.9_615

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[Synthesis of metabolites of mosapramine. I. Synthesis of alcoholic metabolites]

Autor: Syuji Yuasa, Kenichi Demizu, Chiaki Tashiro

Publikováno v: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 112(2)

Four alcoholic metabolites of (+-)-3-chloro-5-[3-(2-oxo-1,2,3,5,6,7,8,8a-octahydroimidazo[1,2-a] pyridine-3-spiro-4'-peperidino)propyl]-10,11-dihydro-5'-dibenz[b,f ] azepine(mosapramine), a new antipsychotic drug, were synthesized in order to determi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fde7697380cec162bfd328a88d1bc52
https://pubmed.ncbi.nlm.nih.gov/1355558

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Piperidine derivatives. 1

Autor: Chiaki Tashiro, Michio Nakanishi, Tatsumi Tsumagari, Hiroshi Imamura, Munakata Tomohiko, Kazuhiko Araki

Publikováno v: Journal of Medicinal Chemistry. 13:644-648

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8bc2cdb7593ccb60ea11ee93b3905525
https://doi.org/10.1021/jm00298a015

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[Synthesis of 2-oxooctahydroimidazo[1,2-alpha]pyridine-3-spiro-4'-piperidine derivatives possessing antiapomorphine activity]

Autor: Chiaki Tashiro, Ichiro Horii, Takemi Fukuda

Publikováno v: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 109(2)

4'-Carbamoyl-1,4'-bipiperidine 1 was dehydrogenated on Pd-C to give 2-oxo-2,3,5,6,7,8-hexahydroimidazo[1,2-alpha]pyridine-3-spiro-4'-p iperidine 2, which was reduced to 2-oxo-1,2,3,5,6,7,8,8a-octahydroimidazo[1,2-alpha]pyridine-3-spiro -4'- piperidin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7563a09539c4a00056ad4bb822719e05
https://pubmed.ncbi.nlm.nih.gov/2568478

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