Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Chiaki Tanoue"'
Autor:
Shigeru Ohta, Kazumi Sugihara, Naoto Uramaru, Shigeyuki Kitamura, Yoshitaka Tayama, Yoko Watanabe, Chiaki Tanoue
Publikováno v:
Drug Metabolism Letters. 10:278-285
Background: Zaleplon (ZAL) is a sedative-hypnotic agent, which is mainly metabolized to inactive 5-oxidized zaleplon (5-oxo-ZAL) and N-des-ethylated ZAL (des-ethyl-ZAL) in mice and humans. The former reaction is considered to be catalyzed by aldehyde
Publikováno v:
The Journal of Dermatology. 41:505-513
Patch testing (PT) can be used to identify allergens and irritants responsible for contact allergic and irritant dermatitis, respectively. However, the reproducibility of PT and correlation between PT and use test has not been fully evaluated. The ai
Autor:
Yoko Watanabe, Chiaki Tanoue, Yoshitaka Tayama, Kazumi Sugihara, Naoto Uramaru, Shigeyuki Kitamura, Shigeru Ohta, Toru Horie
Publikováno v:
Xenobiotica. 43:956-962
1. Human chimeric mice (h-PXB mice) having humanized liver, constructed by transplantation of human hepatocytes, were evaluated as an experimental model for predicting human drug metabolism. Metabolism of zaleplon in h-PXB mice was compared with that
Autor:
Naoto Uramaru, Kazumi Sugihara, Yoshitaka Tayama, Shigeyuki Kitamura, Shigeru Ohta, Yoko Watanabe, Chiaki Tanoue
Publikováno v:
Drug Metabolism and Pharmacokinetics. 28:269-273
The in vivo and in vitro metabolism of the sedative-hypnotic agent zaleplon (ZAL) to 5-hydroxylated ZAL (5-oxo-ZAL) and N-desethylated ZAL (desethyl-ZAL) was studied in four strains of rats. Incubation of ZAL with liver microsomes afforded desethyl-Z
Autor:
Mitsue Yasoshima, Tsutomu Yanagibashi, Kiyoshi Takatsu, Takashi Mochizuki, Masahiro Nishii, Naoki Yoshida, Tomoya Nakamura, Chiaki Tanoue, Yoshinori Nagai, Takayuki Miyamoto, Akiko Nishibu, Kazuo Ogawa, Junko Hatta
Publikováno v:
Journal of Dermatological Science. 66:144-153
Background Trichophyton -induced superficial skin mycosis is a common infectious human disease, but the immunological mechanism against Trichophyton infection is unclear with regard to many points. Since Trichophyton cannot colonize mice, guinea pigs
Autor:
Kazumi Sugihara, Kayoko Nitta, Chiaki Tanoue, Tae Inoue, Shigeru Ohta, Yoshitaka Tayama, Tohru Horie, Shigeyuki Kitamura
Publikováno v:
Drug Metabolism and Disposition. 36:1202-1205
Aldehyde oxidase-mediated oxidation of N(1)-methylnicotinamide to N(1)-methyl-2-pyridine-5-carboxamide (2-PY) and N(1)-methyl-4-pyridone-5-carboxamide (4-PY) in chimeric mice constructed by transplanting human hepatocytes into urokinase-type plasmino