Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Chiaki Iwamura"'
Autor:
Tatsuya Kaneko, MD, PhD, Chiaki Iwamura, PhD, Masahiro Kiuchi, VMD, PhD, Akane Kurosugi, MD, PhD, Miki Onoue, MD, PhD, Tomoaki Matsumura, MD, PhD, Tetsuhiro Chiba, MD, PhD, Toshinori Nakayama, MD, PhD, Naoya Kato, MD, PhD, Kiyoshi Hirahara, MD, PhD
Publikováno v:
Journal of Allergy and Clinical Immunology: Global, Vol 3, Iss 3, Pp 100287- (2024)
Background: Massive eosinophil infiltration into the esophagus is associated with subepithelial fibrosis and esophageal stricture in patients with eosinophilic esophagitis (EoE). However, the pathogenesis of esophageal fibrosis remains unclear. Objec
Externí odkaz:
https://doaj.org/article/bb05d57760a04e08b87307a06e9e63dc
Autor:
Ken Wakai, Kazuhiko Azuma, Chiaki Iwamura, Maihulan Maimaiti, Kosuke Mikami, Kei Yoneda, Shinichi Sakamoto, Sanae Ikehara, Takashi Yamaguchi, Kiyoshi Hirahara, Tomohiko Ichikawa, Toshinori Nakayama, Yuzuru Ikehara
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract In bronchial asthma patients, mucous cell metaplasia (MCM) and fibrosis occur in the bronchial epithelium and interstitium, respectively. The mucus and collagen fibers are identified by Periodic acid-Schiff stain (PAS) or Sirius red stain on
Externí odkaz:
https://doaj.org/article/2201830412074f189bebc8229df2d861
Autor:
Akane S. Suzuki, Ryoji Yagi, Motoko Y. Kimura, Chiaki Iwamura, Kenta Shinoda, Atsushi Onodera, Kiyoshi Hirahara, Damon J. Tumes, Ryo Koyama-Nasu, Siiri E. Iismaa, Robert M. Graham, Shinichiro Motohashi, Toshinori Nakayama
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Memory helper T (Th) cells are crucial for secondary immune responses against infectious microorganisms but also drive the pathogenesis of chronic inflammatory diseases. Therefore, it is of fundamental importance to understand how memory T cells are
Externí odkaz:
https://doaj.org/article/e5a450efae4e4f739d1ac74a3a95f8bf
Autor:
Chiaki Iwamura, Toshinori Nakayama
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Innate T lymphocytes are a group of relatively recently identified T cells that are not involved in either innate or adaptive immunity. Unlike conventional T cells, most innate T lymphocytes express invariant T cell receptor to recognize exogenous no
Externí odkaz:
https://doaj.org/article/5a4c3578c2a94cff85c1b8d6b8004a5a
Autor:
Chiaki Iwamura, Kenta Shinoda, Mineka Yoshimura, Yukiko Watanabe, Akio Obata, Toshinori Nakayama
Publikováno v:
Allergology International, Vol 59, Iss 1, Pp 67-73 (2010)
Background: : Some polyphenols possess anti-allergic activities. Naringenin chalcone is one of the polyphenols that is present in the skin of red tomatoes. In this study, we investigated the effect of naringenin chalcone in allergic responses in vivo
Externí odkaz:
https://doaj.org/article/79eccd2a2d30401ba553be98a10174e3
Autor:
Akihiro Hasegawa, Chiaki Iwamura, Masayuki Kitajima, Kahoko Hashimoto, Ken-Ichiro Otsuyama, Hidetaka Ogino, Toshinori Nakayama, Mutsunori Shirai
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65494 (2013)
CD69 is a membrane molecule transiently expressed on activated lymphocytes, and its selective expression in inflammatory infiltrates suggests that it plays a role in the pathogenesis of inflammatory diseases. In this study, we used CD69-deficient (CD
Externí odkaz:
https://doaj.org/article/5187e75f9b0540839d812d9cb6856645
Autor:
Kota Kokubo, Kiyoshi Hirahara, Masahiro Kiuchi, Kaori Tsuji, Yuki Shimada, Yuri Sonobe, Rie Shinmi, Takahisa Hishiya, Chiaki Iwamura, Atsushi Onodera, Toshinori Nakayama
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 120(2)
CD4 + memory T cells are central to long-lasting protective immunity and are involved in shaping the pathophysiology of chronic inflammation. While metabolic reprogramming is critical for the generation of memory T cells, the mechanisms controlling t
Autor:
Atsushi Onodera, Kota Kokubo, Mikiko Okano, Miki Onoue, Masahiro Kiuchi, Chiaki Iwamura, Tomohisa Iinuma, Motoko Y. Kimura, Nobuyuki Ebihara, Toyoyuki Hanazawa, Toshinori Nakayama, Kiyoshi Hirahara
Publikováno v:
Pharmacology & Therapeutics. 247:108445
Autor:
Kiyoshi Hirahara, Toshinori Nakayama, Kahoko Hashimoto, Atsushi Onodera, Masahiro Kiuchi, Shinichiro Motohashi, Chiaki Iwamura, Motoko Y. Kimura, Kota Kokubo
Publikováno v:
International Immunology. 33:699-704
CD4+ T cells not only direct immune responses against infectious micro-organisms but are also involved in the pathogenesis of inflammatory diseases. In the last two to three decades, various researchers have identified and characterized several funct
Autor:
Chiaki Iwamura, Kiyoshi Hirahara, Masahiro Kiuchi, Sanae Ikehara, Kazuhiko Azuma, Tadanaga Shimada, Sachiko Kuriyama, Syota Ohki, Emiri Yamamoto, Yosuke Inaba, Yuki Shiko, Ami Aoki, Kota Kokubo, Rui Hirasawa, Takahisa Hishiya, Kaori Tsuji, Tetsutaro Nagaoka, Satoru Ishikawa, Akira Kojima, Haruki Mito, Ryota Hase, Yasunori Kasahara, Naohide Kuriyama, Tetsuya Tsukamoto, Sukeyuki Nakamura, Takashi Urushibara, Satoru Kaneda, Seiichiro Sakao, Minoru Tobiume, Yoshio Suzuki, Mitsuhiro Tsujiwaki, Terufumi Kubo, Tadashi Hasegawa, Hiroshi Nakase, Osamu Nishida, Kazuhisa Takahashi, Komei Baba, Yoko Iizumi, Toshiya Okazaki, Motoko Y. Kimura, Ichiro Yoshino, Hidetoshi Igari, Hiroshi Nakajima, Takuji Suzuki, Hideki Hanaoka, Taka-aki Nakada, Yuzuru Ikehara, Koutaro Yokote, Toshinori Nakayama
Publikováno v:
Proceedings of the National Academy of Sciences. 119
The mortality of coronavirus disease 2019 (COVID-19) is strongly correlated with pulmonary vascular pathology accompanied by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection–triggered immune dysregulation and aberrant activati