Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Chiahuey Ooi"'
Autor:
Maurizio Ceppi, Bruno Gomes, Irina Klaman, Marta Canamero, Christian Heichinger, Tamara Tanos, Sabine Wilson, Mariana Bustamante, Chiahuey Ooi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/868e8b0a3c99497299b42e38438c364c
Autor:
Ignacio Melero, Tamara Tanos, Mariana Bustamante, Miguel F. Sanmamed, Emiliano Calvo, Irene Moreno, Victor Moreno, Tatiana Hernandez, Maria Martinez Garcia, Alejo Rodriguez-Vida, Josep Tabernero, Analia Azaro, Mariano Ponz-Sarvisé, Iben Spanggaard, Kristoffer Rohrberg, Ernesto Guarin, Eveline Nüesch, Iakov I. Davydov, Chiahuey Ooi, José Duarte, Evelyne Chesne, Christine McIntyre, Maurizio Ceppi, Marta Cañamero, Oliver Krieter
Publikováno v:
Science Translational Medicine. 15
This first-in-human study evaluated RO7122290, a bispecific fusion protein carrying a split trimeric 4-1BB (CD137) ligand and a fibroblast activation protein α (FAP) binding site that costimulates T cells for improved tumor cell killing in FAP-expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c21d1128067bd586b01f93f4a042a37a
https://doi.org/10.1126/scitranslmed.abp9229
https://doi.org/10.1126/scitranslmed.abp9229
Autor:
Tamara Tanos, Kevin Smart, Valentina Gambardella, Kristoffer Rohrberg, Michael Ong, Maria Esperanza Rodriguez Ruiz, Jean-Pascal Machiels, Miguel Fernández Sanmamed, Josep Tabernero, Anna Spreafico, Daniel Renouf, Stephen Luen, Rachel Galot, Bernard Doger, Emiliano Calvo, Aung Naing, Samira Curdt, Nicolas Staedler, Mike Flores, Enrique Gómez Alcaide, Chiahuey Ooi, Michael Hettich, Sebastian Dziadek, Yuying Xie, Gabriel Schnetzler, Theresa Kolben, Linxinyu Xu, Vaios Karanikas, Christophe Boetsch
Publikováno v:
Cancer Research. 83:CT176-CT176
INTRODUCTION: Activated Tregs in the tumor micro-environment are correlated with poor outcomes, and are considered as key players in tumor immune-escape. So far, Treg depletion has not been successful in patients, either because adequate Treg depleti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::217a7c59c9c441d0bb31a8fa513d8cd9
https://doi.org/10.1158/1538-7445.am2023-ct176
https://doi.org/10.1158/1538-7445.am2023-ct176
Autor:
Tamara Tanos, Christian Heichinger, Sabine Wilson, Marta Canamero, Mariana Bustamante, Chiahuey Ooi, Irina Klaman, Bruno Gomes, Maurizio Ceppi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundWe previously described the capacity of RO7122290 (RO) - a FAP-targeted 4-1BB bispecific antibody - to induce CD8+ T cell infiltration and activation in the tumor (Moreno V. et al, SITC 2020). Aiming to compare pharmacodynamic (PD) changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::037e1da6b9d3b5cdd0ca86ca4545c253
https://doi.org/10.1136/jitc-2021-sitc2021.527
https://doi.org/10.1136/jitc-2021-sitc2021.527