Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Chiaho Shih"'
Autor:
Chih-Hsu Chang, Chiaho Shih
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-14 (2024)
Abstract Background It is generally believed that hepatitis B virus (HBV) core protein (HBc) dephosphorylation (de-P) is important for viral DNA synthesis and virion secretion. HBV polymerase contains four domains for terminal protein, spacer, revers
Externí odkaz:
https://doaj.org/article/9bcaee80437f419caacf32ac4b80414b
Publikováno v:
Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-16 (2022)
Abstract Background Hepatitis B virus (HBV) is a major human pathogen worldwide. To date, there is no curative treatment for chronic hepatitis B. The mechanism of virion secretion remains to be investigated. Previously, we found that nuclear export o
Externí odkaz:
https://doaj.org/article/2d36e4a7b21d4504afc6b382465902c8
Publikováno v:
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-14 (2021)
Abstract Background The virion secretion mechanism of human hepatitis B virus (HBV) remains to be investigated. In our current study, we characterized a reverse transcriptase mutant, which changed from the YMDD motif to YMHA. We noted that this mutan
Externí odkaz:
https://doaj.org/article/70350f114ccb4ddca3c6ea7e42a31ef1
Autor:
Chiaho Shih
The scope of the book is very broad, covering a wide range of areas in HBV/HDV and HCV research, including both basic and clinical science. The selected topics range from epidemiology, immunology, molecular virology and oncology, to clinical therapy.
Autor:
Ching-Chun Yang, Chih-Hsu Chang, Heng-Li Chen, Ming-Chieh Chou, Ching-Jen Yang, Ren-Shiang Jhou, Er-Yi Huang, Hung-Cheng Li, Ching-Shu Suen, Ming-Jing Hwang, Chiaho Shih
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110472- (2022)
Summary: Hepatitis B virus (HBV) is a global pathogen. We report here that the cellular CRM1 machinery can mediate nuclear export of entire HBV core (HBc) particles containing encapsidated viral RNAs. Two CRM1-mediated nuclear export signals (NESCRM1
Externí odkaz:
https://doaj.org/article/5a528bb9aafa41d2b5d8fc3ad3130db4
Autor:
Pei-Yi (Alma) Su, Chih-Hsu Chang, Shin-Chwen Bruce Yen, Hsiu-Yi Wu, Wan-Ju Tung, Yu-Pei Hu, Yen-Yu Ian Chen, Miao-Hsia Lin, Chiaho Shih, Pei-Jer Chen, Tsai, Kevin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 6/11/2024, Vol. 121 Issue 24, p1-15, 24p
Publikováno v:
Journal of Biomedical Science, Vol 26, Iss 1, Pp 1-14 (2019)
Abstract Background Enterovirus 71 (EV71 or EV-A71) was first identified in California about half a century ago. In recent years, outbreaks of EV-A71 were prevalent worldwide, including Taiwan, Malaysia, Singapore, Japan, and China. Between 2008 and
Externí odkaz:
https://doaj.org/article/43484ad6543f4077bc40e5e1c22a748b
Autor:
Chih-Shin Chang, Chun-Che Liao, An-Ting Liou, Yi-Chun Chou, Ya-Yen Yu, Chi-Yung Lin, Jen-Shiou Lin, Ching-Shu Suen, Ming-Jing Hwang, Chiaho Shih
Publikováno v:
Frontiers in Microbiology, Vol 11 (2021)
Infection with the re-emerging enterovirus 71 (EV-A71) is associated with a wide range of disease severity, including herpangina, encephalitis, and cardiopulmonary failure. At present, there is no FDA-approved therapeutics for EV-A71. Early diagnosis
Externí odkaz:
https://doaj.org/article/10d8cba4bf8b4116bcc99c35b56a1f91
Autor:
Yu-Li Lin, Chiaho Shih, Pei-Yun Cheng, Chiao-Li Chin, An-Ting Liou, Po-Yi Lee, Bor-Luen Chiang
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Enterovirus A71 (EV-A71), the pathogen responsible for the seasonal hand-foot-and-mouth epidemics, can cause significant mortality in infants and young children. The vaccine against EV-A71 could potentially prevent virus-induced neurological complica
Externí odkaz:
https://doaj.org/article/a30e0a6acd984f50a53b298e6ac0c66b
Publikováno v:
Cells, Vol 10, Iss 1, p 43 (2020)
In natural infection, hepatitis B virus (HBV) core protein (HBc) accumulates frequent mutations. The most frequent HBc variant in chronic hepatitis B patients is mutant 97L, changing from an isoleucine or phenylalanine to a leucine (L) at HBc amino a
Externí odkaz:
https://doaj.org/article/8f52cc5eed3844399fdcd86b945ca5f9