Timing of Intubation in Coronavirus Disease 2019: A Study of Ventilator Mechanics, Imaging, Findings, and Outcomes

Autor: Avni A. Bavishi, MD, MS, Ruben J. Mylvaganam, MD, Rishi Agarwal, MD, Ryan J. Avery, MD, Michael J. Cuttica, MD, For the NU COVID Investigators, A. Christine Argento, Ajay A. Wagh, Alexander V. Misharin, Alexandra C. McQuattie-Pimentel, Alexis Rose Wolfe, Alvaro Donayre, Ankit Bharat, Anna E. Pawlowski, Anne R. Levenson, Anthony M. Joudi, Benjamin D. Singer, Betty Tran, Catherine A. Gao, Chao Qi, Chiagozie O. Pickens, Chitaru Kurihara, Clara J. Schroedl, Daniel Meza, Daniel Schneider, David A. Kidd, David D. Odell, David W. Kamp, Elizabeth S. Malsin, Emily M. Leibenguth, Eric P. Cantey, Gabrielle Y. Liu, G. R. Scott Budinger, Helen K. Donnelly, Isaac A. Goldberg, Jacob I. Sznajder, Jacqueline M. Kruser, James M. Walter, Jane E. Dematte, Jason M. Arnold, John Coleman, Joseph I. Bailey, Joseph S. Deters, Justin A. Fiala, Katharine Secunda, Kaitlyn Vitale, Khalilah L. Gates, Kristy Todd, Lindsey D. Gradone, Lindsey N. Textor, Lisa F. Wolfe, Lorenzo L. Pesce, Luisa Morales-Nebreda, Madeline L. Rosenbaum, Manu Jain, Marc A. Sala, Mary Carns, Marysa V. Leya, Mengjia Kang, Michael J. Alexander, Michael J. Cuttica, Michelle Hinsch Prickett, Natalie Jensema, Nicole Borkowski, Nikolay S. Markov, Orlyn R. Rivas, Paul A. Reyfman, Peter H. S. Sporn, Prasanth Nannapaneni, Rachel B. Kadar, Rachel M. Kaplan, Rade Tomic, Radhika Patel, Rafael Garza-Castillon, Ravi Kalhan, Richard G. Wunderink, Rogan A. Grant, Romy Lawrence, Ruben J. Mylvaganam, Samuel S. Kim, Sanket Thakkar, Sean B. Smith, SeungHye Han, Sharon R. Rosenberg, Susan R. Russell, Sydney M. Hyder, Taylor A. Poor, Theresa A. Lombardo, Zasu M. Klug

Publikováno v: Critical Care Explorations, Vol 3, Iss 5, p e0415 (2021)

Objectives:. Determine the variation in outcomes and respiratory mechanics between the subjects who are intubated earlier versus later in their coronavirus disease 2019 course. Design:. Retrospective cohort study. Setting:. Northwestern Memorial Hosp

Externí odkaz: https://doaj.org/article/a5ecd5f3973e465d9c9346646dbe1a1d

Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia

Autor: Darryl A. Abbott, Sean B. Smith, Ali Shilatifard, Daniel Schneider, Benjamin D. Singer, Alexander V. Misharin, Luisa Morales-Nebreda, NU Script Study Investigators, Lango Sichizya, Nikolay S. Markov, G. R. Scott Budinger, Hiam Abdala-Valencia, Ankit Bharat, Chao Qi, Elizabeth S. Malsin, Prasanth Nannapaneni, Anna Pawlowski, Helen K. Donnelly, Alvaro Donayre, Cara J. Gottardi, Yuliya Politanska, Zasu M Klug, Melissa Querrey, Suchitra Swaminathan, Mengjia Kang, Richard G Wunderink, Chiagozie O Pickens, Jacqueline M. Kruser, Hermon Kihshen, James M. Walter, Estefany R Guzman, Ziyan Lu, Nicole Borkowski, Rogan A. Grant, Isaac Goldberg, A. Christine Argento, Jon W. Lomasney

Publikováno v: Nature
bioRxiv

Some patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develop severe pneumonia and acute respiratory distress syndrome1 (ARDS). Distinct clinical features in these patients have led to speculation that the immune re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d156b55299235ad6e217891e2a6166
http://europepmc.org/articles/PMC7987233

Bacterial superinfection pneumonia in SARS-CoV-2 respiratory failure

Autor: Chao Qi, Luisa Morales-Nebreda, Lorenzo L. Pesce, Mengjia Kang, Avni Bavishi, Michael J. Cuttica, Sean B. Smith, Catherine A Gao, Anna Pawlowski, G. R. Scott Budinger, Richard G. Wunderink, NU Covid Investigators, Rogan A. Grant, Jason Arnold, Chiagozie O Pickens, Benjamin D. Singer

Publikováno v: medRxiv

BackgroundSevere community-acquired pneumonia secondary to SARS-CoV-2 is a leading cause of death. Current guidelines recommend patients with SARS-CoV-2 pneumonia receive empirical antibiotic therapy for suspected bacterial superinfection, but little

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d725ac5d676035f85eacc6a4df7cfc1
https://doi.org/10.1101/2021.01.12.20248588

Microbiologic Diagnosis Is Associated with Differing Antibiotic Use Patterns in Severe Community-Acquired Pneumonia

Autor: D.M. Scholtens, Richard G. Wunderink, James M. Walter, Helen K. Donnelly, Jacqueline M. Kruser, Chiagozie O Pickens, Anna Pawlowski, H. He, Benjamin D. Singer, A.A. Wang

Publikováno v: A59. CLINICAL DIAGNOSIS, PREDICTION AND OUTCOMES OF LUNG INFECTIONS.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7636b0c48ca06fea028ace237b74dc9a
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2123

Detection of respiratory pathogens in clinical samples using metagenomic shotgun sequencing

Autor: Stefan J. Green, Benjamin D. Singer, James M. Walter, Patrick C. Seed, Richard G. Wunderink, Jacqueline M. Kruser, Chao Qi, Chiagozie O Pickens, Peter Hountras

Publikováno v: Journal of medical microbiology. 68(7)

Purpose. In this pilot study, we used shotgun metagenome sequencing (SMS) strategy on bronchoalveolar lavage (BAL) samples from hospitalized patients with suspected ventilate-associated pneumonia (VAP) in order to explore its potential for improving

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ffad70e5506da2b7c5f5c189e9ae049
https://pubmed.ncbi.nlm.nih.gov/32005297