Biological characterization of AB-343, a novel and potent SARS-CoV-2 M ^pro inhibitor with pan-coronavirus activity.

Autor: McGovern-Gooch KR; Arbutus Biopharma, Inc., Warminster, PA, USA. Electronic address: kmcgoverngooch@gmail.com., Mani N; Arbutus Biopharma, Inc., Warminster, PA, USA., Gotchev D; Arbutus Biopharma, Inc., Warminster, PA, USA., Ardzinski A; Arbutus Biopharma, Inc., Warminster, PA, USA., Kowalski R; Arbutus Biopharma, Inc., Warminster, PA, USA., Sheraz M; Arbutus Biopharma, Inc., Warminster, PA, USA., Micolochick Steuer HM; Arbutus Biopharma, Inc., Warminster, PA, USA., Tercero B; Arbutus Biopharma, Inc., Warminster, PA, USA., Wang X; Arbutus Biopharma, Inc., Warminster, PA, USA., Wasserman A; Arbutus Biopharma, Inc., Warminster, PA, USA., Chen CY; Proteros Biostructures GmbH, D-82152, Martinsried, Germany., von König K; Proteros Biostructures GmbH, D-82152, Martinsried, Germany., Maskos K; Proteros Biostructures GmbH, D-82152, Martinsried, Germany., Prasad A; Proteros Biostructures GmbH, D-82152, Martinsried, Germany., Blaesse M; Proteros Biostructures GmbH, D-82152, Martinsried, Germany., Bergmann A; Proteros Biostructures GmbH, D-82152, Martinsried, Germany., Konz Makino DL; Proteros Biostructures GmbH, D-82152, Martinsried, Germany., Fan KY; Arbutus Biopharma, Inc., Warminster, PA, USA., Kultgen SG; Arbutus Biopharma, Inc., Warminster, PA, USA., Lindstrom A; Arbutus Biopharma, Inc., Warminster, PA, USA., Nguyen D; Arbutus Biopharma, Inc., Warminster, PA, USA., Vega M; Arbutus Biopharma, Inc., Warminster, PA, USA., Wang X; Arbutus Biopharma, Inc., Warminster, PA, USA., Bracci N; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Weiss SR; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Cole AG; Arbutus Biopharma, Inc., Warminster, PA, USA., Lam AM; Arbutus Biopharma, Inc., Warminster, PA, USA., Cuconati A; Arbutus Biopharma, Inc., Warminster, PA, USA., Sofia MJ; Arbutus Biopharma, Inc., Warminster, PA, USA.

Publikováno v: Antiviral research [Antiviral Res] 2024 Dec; Vol. 232, pp. 106038. Date of Electronic Publication: 2024 Nov 20.

Proteometabolomics of initial and recurrent glioblastoma highlights an increased immune cell signature with altered lipid metabolism.

Autor: Cosenza-Contreras M; Institute of Surgical Pathology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Schäfer A; Department of Neurosurgery, Philipps University Marburg, Marburg, Germany., Sing J; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada., Cook L; Department of Neurosurgery, Philipps University Marburg, Marburg, Germany., Stillger MN; Institute of Surgical Pathology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Chen CY; Institute of Molecular Medicine and Cell Research, University of Freiburg, Freiburg, Germany., Villacorta Hidalgo J; Institute of Surgical Pathology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany., Pinter N; Institute of Surgical Pathology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany., Meyer L; Institute of Surgical Pathology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany., Werner T; Institute of Surgical Pathology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany.; Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany., Bug D; Department of Neurosurgery, Philipps University Marburg, Marburg, Germany., Haberl Z; Department of Neurosurgery, Philipps University Marburg, Marburg, Germany., Kübeck O; Department of Neurosurgery, Philipps University Marburg, Marburg, Germany., Zhao K; Department of Neurosurgery, Philipps University Marburg, Marburg, Germany., Stei S; Department of Neurosurgery, Philipps University Marburg, Marburg, Germany., Gafencu AV; Institute of Cellular Biology and Pathology ' Nicolae Simionescu,' Bucharest, Romania., Ionita R; Institute of Cellular Biology and Pathology ' Nicolae Simionescu,' Bucharest, Romania., Brehar FM; Department of Neurosurgery, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.; Bagdasar-Arseni' Emergency Clinical Hospital, Bucharest, Romania., Ferrer-Lozano J; Department of Pathology Hospital Universitari i Politècnic La Fe, València, Spain., Ribas G; Biomedical Imaging Research Group (GIBI230) Instituto de Investigación Sanitaria La Fe, Valencia, Spain., Cerdá-Alberich L; Biomedical Imaging Research Group (GIBI230) Instituto de Investigación Sanitaria La Fe, Valencia, Spain., Martí-Bonmatí L; Department of Pathology Hospital Universitari i Politècnic La Fe, València, Spain.; Department of Radiology Hospital Universitari i Politècnic La Fe, València, Spain., Nimsky C; Department of Neurosurgery, Philipps University Marburg, Marburg, Germany., Van Straaten A; Department of medical informatics and evaluation of practices, Assistance Publique-Hôpitaux de Paris Centre, Paris University & European Hospital Georges Pompidou, Paris, France., Biniossek ML; Institute of Molecular Medicine and Cell Research, University of Freiburg, Freiburg, Germany., Föll M; Institute of Surgical Pathology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Khoury College of Computer Sciences, Northeastern University, Boston, USA., Cabezas-Wallscheid N; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany., Büscher J; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany., Röst H; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada., Arnoux A; Clinical Epidemiology INSERM & Clinical Research Unit, Assistance Publique-Hôpitaux de Paris Centre, Paris University & European Hospital Georges Pompidou, Paris, France., Bartsch JW; Department of Neurosurgery, Philipps University Marburg, Marburg, Germany., Schilling O; Institute of Surgical Pathology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany.

Publikováno v: Neuro-oncology [Neuro Oncol] 2024 Mar 04; Vol. 26 (3), pp. 488-502.

Targeting CD73 increases therapeutic response to immunogenic chemotherapy by promoting dendritic cell maturation.

Autor: Lin YS; Department of Pathology, China Medical University Hospital, China Medical University, Taichung, 40402, Taiwan, ROC., Chiang SF; Lab of Precision Medicine, Feng-Yuan Hospital, Ministry of Health and Welfare, Taichung, 42055, Taiwan, ROC., Chen CY; Proton Therapy and Science Center, China Medical University Hospital, China Medical University, Taichung, 40402, Taiwan, ROC., Hong WZ; Proton Therapy and Science Center, China Medical University Hospital, China Medical University, Taichung, 40402, Taiwan, ROC., Chen TW; Graduate Institute of Biomedical Science, China Medical University, Taichung, 40402, Taiwan, ROC.; Department of Pathology, Asia University Hospital, Asia University, Taichung, 41354, Taiwan, ROC., Chen WT; Department of Colorectal Surgery, China Medical University HsinChu Hospital, China Medical University, HsinChu, 302, Taiwan, ROC.; Department of Colorectal Surgery, China Medical University Hospital, China Medical University, Taichung, 40402, Taiwan, ROC.; Department of Surgery, School of Medicine, China Medical University, Taichung, 40402, Taiwan, ROC., Ke TW; Department of Colorectal Surgery, China Medical University Hospital, China Medical University, Taichung, 40402, Taiwan, ROC.; School of Chinese Medicine, China Medical University, Taichung, 40402, Taiwan, ROC., Yang PC; Proton Therapy and Science Center, China Medical University Hospital, China Medical University, Taichung, 40402, Taiwan, ROC., Liang JA; Department of Radiation Oncology, China Medical University Hospital, China Medical University, Taichung, Taiwan, ROC.; Department of Radiotherapy, School of Medicine, China Medical University Hospital, China Medical University, Taichung, 40402, Taiwan, ROC., Shiau AC; Proton Therapy and Science Center, China Medical University Hospital, China Medical University, Taichung, 40402, Taiwan, ROC.; Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, 40402, Taiwan, ROC., Chao KSC; Proton Therapy and Science Center, China Medical University Hospital, China Medical University, Taichung, 40402, Taiwan, ROC. d94032@mail.cmuh.org.tw.; Graduate Institute of Biomedical Science, China Medical University, Taichung, 40402, Taiwan, ROC. d94032@mail.cmuh.org.tw.; Department of Radiation Oncology, China Medical University Hospital, China Medical University, Taichung, Taiwan, ROC. d94032@mail.cmuh.org.tw.; Department of Radiotherapy, School of Medicine, China Medical University Hospital, China Medical University, Taichung, 40402, Taiwan, ROC. d94032@mail.cmuh.org.tw., Huang KC; Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, 40402, Taiwan, ROC. chihyang0425@mail.cmu.edu.tw.; Translation Research Core, China Medical University Hospital, China Medical University, Taichung, 40402, Taiwan, ROC. chihyang0425@mail.cmu.edu.tw.

Publikováno v: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2023 Jul; Vol. 72 (7), pp. 2283-2297. Date of Electronic Publication: 2023 Mar 07.

HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice.

Autor: Hoefflin R; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Harlander S; Institute of Physiology, University of Zurich, Zurich, Switzerland.; Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland., Schäfer S; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Metzger P; Faculty of Biology, University of Freiburg, Freiburg, Germany.; Institute of Medical Bioinformatics and Systems Medicine, Medical Centre-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Kuo F; Immunogenomics & Precision Oncology Platform (IPOP), Memorial Sloan Kettering Cancer Center, New York, NY, USA., Schönenberger D; Institute of Physiology, University of Zurich, Zurich, Switzerland.; Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland., Adlesic M; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany., Peighambari A; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Seidel P; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany., Chen CY; Institute for Surgical Pathology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Consenza-Contreras M; Institute for Surgical Pathology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Jud A; Department of General and Visceral Surgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Lahrmann B; Hamamatsu Tissue Imaging and Analysis (TIGA) Center, BioQuant, University of Heidelberg, Heidelberg, Germany., Grabe N; Hamamatsu Tissue Imaging and Analysis (TIGA) Center, BioQuant, University of Heidelberg, Heidelberg, Germany., Heide D; Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Uhl FM; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Chan TA; Immunogenomics & Precision Oncology Platform (IPOP), Memorial Sloan Kettering Cancer Center, New York, NY, USA., Duyster J; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Comprehensive Cancer Center Freiburg (CCCF), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Zeiser R; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Comprehensive Cancer Center Freiburg (CCCF), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Schell C; Institute for Surgical Pathology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Heikenwalder M; Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Schilling O; Institute for Surgical Pathology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Comprehensive Cancer Center Freiburg (CCCF), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), Partner Site Freiburg, and German Cancer Research Center (DKFZ), Heidelberg, Germany., Hakimi AA; Immunogenomics & Precision Oncology Platform (IPOP), Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Boerries M; Institute of Medical Bioinformatics and Systems Medicine, Medical Centre-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Comprehensive Cancer Center Freiburg (CCCF), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), Partner Site Freiburg, and German Cancer Research Center (DKFZ), Heidelberg, Germany., Frew IJ; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. ian.frew@uniklinik-freiburg.de.; Institute of Physiology, University of Zurich, Zurich, Switzerland. ian.frew@uniklinik-freiburg.de.; Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland. ian.frew@uniklinik-freiburg.de.; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany. ian.frew@uniklinik-freiburg.de.; Faculty of Biology, University of Freiburg, Freiburg, Germany. ian.frew@uniklinik-freiburg.de.; Comprehensive Cancer Center Freiburg (CCCF), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. ian.frew@uniklinik-freiburg.de.

Publikováno v: Nature communications [Nat Commun] 2020 Aug 17; Vol. 11 (1), pp. 4111. Date of Electronic Publication: 2020 Aug 17.

N-Terminomics identifies HtrA1 cleavage of thrombospondin-1 with generation of a proangiogenic fragment in the polarized retinal pigment epithelial cell model of age-related macular degeneration.

Autor: Chen CY; Institute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Melo E; Roche Pharma Research and Early Development, Neuroscience Ophthalmology and Rare Diseases Discovery & Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Jakob P; Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Friedlein A; Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Elsässer B; Division of Structural Biology, Department of Biosciences, University of Salzburg, Billrothstrasse 11, 5020 Salzburg, Austria., Goettig P; Division of Structural Biology, Department of Biosciences, University of Salzburg, Billrothstrasse 11, 5020 Salzburg, Austria., Kueppers V; Roche Pharma Research and Early Development, Neuroscience Ophthalmology and Rare Diseases Discovery & Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Delobel F; Roche Pharma Research and Early Development, Neuroscience Ophthalmology and Rare Diseases Discovery & Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Stucki C; Roche Pharma Research and Early Development, Neuroscience Ophthalmology and Rare Diseases Discovery & Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Dunkley T; Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Fauser S; Roche Pharma Research and Early Development, Neuroscience Ophthalmology and Rare Diseases Discovery & Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Schilling O; Institute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, Freiburg, Germany; BIOSS Centre for Biological Signaling Studies, University of Freiburg, 79104 Freiburg, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. Electronic address: oliver.schilling@mol-med.uni-freiburg.de., Iacone R; Roche Pharma Research and Early Development, Neuroscience Ophthalmology and Rare Diseases Discovery & Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.

Publikováno v: Matrix biology : journal of the International Society for Matrix Biology [Matrix Biol] 2018 Sep; Vol. 70, pp. 84-101. Date of Electronic Publication: 2018 Mar 20.