Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Chia-Yang Liu"'
Autor:
Winston W. Y. Kao, Jianhua Zhang, Jhuwala Venkatakrishnan, Shao-Hsuan Chang, Yong Yuan, Osamu Yamanaka, Ying Xia, Tarsis F. Gesteira, Sudhir Verma, Vivien J. Coulson-Thomas, Chia-Yang Liu
Publikováno v:
Cells, Vol 13, Iss 19, p 1599 (2024)
The synthetic peptide of lumican C-terminal 13 amino acids with the cysteine replaced by an alanine, hereafter referred to as lumikine (LumC13C-A: YEALRVANEVTLN), binds to TGFβ type I receptor/activin-like kinase5 (TBR1/ALK5) in the activated TGFβ
Externí odkaz:
https://doaj.org/article/edf81ec16f7c43ccb0e1b8e2f51c11a5
Publikováno v:
Cells, Vol 13, Iss 7, p 626 (2024)
(1) Background: Our previous data indicated that disturbance of the Transforming Growth Factor beta (TGFB) signaling pathway via its Type-2 Receptor (TGFBR2) can cause a Corneal Ectasia (CE)-like phenotype. The purpose of this study is to elucidate w
Externí odkaz:
https://doaj.org/article/041cacb55d3046ab967f55cfd5acdc51
Autor:
Shingo Yasuda, Takayoshi Sumioka, Masayasu Miyajima, Hiroki Iwanishi, Tomoya Morii, Naoki Mochizuki, Peter S. Reinach, Winston W.Y. Kao, Yuka Okada, Chia-Yang Liu, Shizuya Saika
Publikováno v:
The Ocular Surface. 26:111-127
Spinster 2 (Spns2) is a transporter that pumps sphingosine-1-phosphate (S1P), a bioactive lipid mediator synthesized in the cytoplasm, out of cells into the inter cellular space. S1P is a signal that modulates cellular behavior during embryonic devel
Autor:
Yujin Zhang, Joseph Jeffrey, Fei Dong, Jianhua Zhang, Winston W.-Y. Kao, Chia-Yang Liu, Yong Yuan
Publikováno v:
Journal of Ophthalmology, Vol 2019 (2019)
Purpose. Ocular aging is a natural process of functional decline in vision. When the process reaches a point that compromised vision affects normal daily activity, it manifests as age-related ocular diseases, such as age-related macular degeneration,
Externí odkaz:
https://doaj.org/article/ea9b0d48e88e463eb2413e5c650813c4
Publikováno v:
Bio-Protocol, Vol 6, Iss 19 (2016)
This protocol is developed for primary cell culture of cornea stromal keratocytes isolated from neonatal mouse eyeballs. It provides an optimal condition to isolate stromal keratocytes which maintain high viability for cell culture.
Externí odkaz:
https://doaj.org/article/cf88f51827a4448e906800f382ee4778
Autor:
Chia-Yang Liu, Shizuya Saika, Lung Kun Yeh, Lingling Zhang, Yuka Okada, Yen Chiao Wang, Yujin Zhang
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology
Corneal nerve fibers serving sensory, reflex and neurotrophic functions sustains the corneal homeostasis and transparency to warrant the normal visual function. It remains unknown whether corneal epithelium is also reciprocally important for the corn
Autor:
Rajalekshmy Shyam, Diego G. Ogando, Joseph A. Bonanno, Chia-Yang Liu, Yen-Chiao Wang, Edward T. Kim
Publikováno v:
Investigative ophthalmologyvisual science. 62(7)
Purpose The conventional Slc4a11 knockout (KO) shows significant corneal edema at eye opening, a fact that complicates the study of the initial events leading to edema. An inducible KO would provide opportunities to examine early events following los
Autor:
Peter S. Reinach, Masayasu Miyajima, Shizuya Saika, Yuka Okada, Kana Ichikawa, Hiroki Iwanishi, Takayoshi Sumioka, Chia-Yang Liu, Keiko Usui-Kusumoto
Publikováno v:
Experimental Eye Research. 181:90-97
Corneal neovascularization and inflammatory fibrosis induced by severe injury or infection leads to tissue opacification and even blindness. Transient receptor potential (TRP) channel subtypes contribute to mediating these maladaptive responses throu
Autor:
Chia-Yang Liu, Atsushi Nambu, Yoshiro Suzuki, Winston Whei-Yang Kao, Masayasu Miyajima, Kenta Kobayashi, Makoto Tominaga, Takayoshi Sumioka, Kunitoshi Uchida, Hiromi Sano, Shizuya Saika, James V. Jester, Peter S. Reinach, Yuka Okada, Hiroki Iwanishi, Kumi Shirai, Syu-ichi Hirai, Kana Ichikawa
Publikováno v:
Laboratory Investigation. 99:210-230
In order to understand the pathobiology of neurotrophic keratopathy, we established a mouse model by coagulating the first branch of the trigeminal nerve (V1 nerve). In our model, the sensory nerve in the central cornea disappeared and remaining fibe
Autor:
Yujin Zhang, Yuka Okada, Yen Chiao Wang, Suohui Zhang, Lingling Zhang, Matthew Anderson, Chia-Yang Liu
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
We previously reported that genetic deletion of β-catenin in mouse corneal keratocytes resulted in precocious corneal epithelial stratification. In this study, to strengthen the notion that corneal keratocyte-derived Wnt/β-catenin signaling regulat