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pro vyhledávání: '"Chia-Wen Wong"'
Autor:
Chia-Wen Wong, Chih-Cheng Chen
Publikováno v:
Journal of Cellular and Molecular Medicine
Acid-sensing ion channels (ASICs) are voltage-insensitive cation channels responding to extracellular acidification. ASIC proteins have two transmembrane domains and a large extracellular domain. The molecular topology of ASICs is similar to that of
Publikováno v:
Pharmacologytherapeutics. 134(2)
The acid-sensing ion channel 3 (ASIC3) is a pH sensor that responds to mild extracellular acidification and is predominantly expressed in nociceptors. There is much interest in targeting ASIC3 to relieve pain associated with tissue acidosis, and sele
Autor:
Wei-Nan Chen, Cheng-Han Lee, Shing-Hong Lin, Chia-Wen Wong, Wei-Hsin Sun, Wood, John N., Chih-Cheng Chen
Publikováno v:
Molecular Pain; 2014, Vol. 10 Issue 1, p1-30, 30p, 3 Color Photographs, 2 Charts, 6 Graphs
Autor:
Wei-Nan Chen, Cheng-Han Lee, Shing-Hong Lin, Chia-Wen Wong, Wei-Hsin Sun, Wood, John N., Chih-Cheng Chen
Publikováno v:
Molecular Pain; 2014, Vol. 10 Issue 1, p1-15, 15p, 3 Diagrams, 2 Charts, 6 Graphs
Autor:
Chia Wen Wong, Wei Nan Chen, John N. Wood, Cheng-Han Lee, Wei Hsin Sun, Shing Hong Lin, Chih-Cheng Chen
Publikováno v:
Molecular Pain
Background Tissue acidosis is effective in causing chronic muscle pain. However, how muscle nociceptors contribute to the transition from acute to chronic pain is largely unknown. Results Here we showed that a single intramuscular acid injection indu