Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Chia-Ron Yang"'
Autor:
Tai-Yuan Ho, Ting-Yi Sung, Shiow-Lin Pan, Wei-Jan Huang, Kai-Cheng Hsu, Jui-Yi Hsu, Tony Eight Lin, Chia-Ming Hsu, Chia-Ron Yang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 162, Iss , Pp 114667- (2023)
Prostate cancer is a prevalent malignancy among men globally, and androgen deprivation therapy is the conventional first-line treatment for metastatic prostate cancer. While androgen deprivation therapy is efficacious in castration-sensitive prostate
Externí odkaz:
https://doaj.org/article/5d7e46c37792443caf9c4aefa81a1f09
Autor:
Jui-Yi Hsu, Kai-Cheng Hsu, Ching Sun, Ching-Hsuan Chou, Tony Eight Lin, Tzu-Ying Sung, Hui-Ju Tseng, Shih-Chung Yen, Chia-Ron Yang, Wei-Jan Huang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 159, Iss , Pp 114258- (2023)
Cyclin-dependent protein kinase 8 (CDK8) plays important roles in regulating fibrotic growth factors and inflammatory signaling pathways. Long-term chronic inflammation of the lungs can lead to idiopathic pulmonary fibrosis (IPF). Abnormal alveolar e
Externí odkaz:
https://doaj.org/article/69ee12bcfc574e07acf7e07b3ddb8146
Autor:
Tony Eight Lin, Li-Chin Sung, Min-Wu Chao, Min Li, Jia-Huei Zheng, Tzu-Ying Sung, Jui-Hua Hsieh, Chia-Ron Yang, Hsueh-Yun Lee, Er-Chieh Cho, Kai-Cheng Hsu
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 226-235 (2022)
Bruton tyrosine kinase (BTK) is linked to multiple signalling pathways that regulate cellular survival, activation, and proliferation. A covalent BTK inhibitor has shown favourable outcomes for treating B cell malignant leukaemia. However, covalent i
Externí odkaz:
https://doaj.org/article/4eee7f20c593416abeb5853c9de04c92
Autor:
Yi-Wen Wu, Min-Wu Chao, Huang-Ju Tu, Liang-Chieh Chen, Kai-Cheng Hsu, Jing-Ping Liou, Chia-Ron Yang, Shih-Chung Yen, Wei-Chun HuangFu, Shiow-Lin Pan
Publikováno v:
Oncogenesis, Vol 10, Iss 5, Pp 1-14 (2021)
Abstract Acute leukemia is a highly heterogeneous disease; therefore, combination therapy is commonly used for patient treatment. Drug–drug interaction is a major concern of combined therapy; hence, dual/multi-target inhibitors have become a domina
Externí odkaz:
https://doaj.org/article/8dd26522ac6d4593b41471029e8816c9
Autor:
Min-Wu Chao, Tony Eight Lin, Wei-Chun HuangFu, Chao-Di Chang, Huang-Ju Tu, Liang-Chieh Chen, Shih-Chung Yen, Tzu-Ying Sung, Wei-Jan Huang, Chia-Ron Yang, Shiow-Lin Pan, Kai-Cheng Hsu
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 98-108 (2021)
The STE20 kinase family is a complex signalling cascade that regulates cytoskeletal organisation and modulates the stress response. This signalling cascade includes various kinase mediators, such as TAOK1 and MAP4K5. The dysregulation of the STE20 ki
Externí odkaz:
https://doaj.org/article/a23f5c3bf07c4ef483bac5eb846abc10
Autor:
Tony Eight Lin, Chia-Ron Yang, Ching-Hsuan Chou, Jui-Yi Hsu, Min-Wu Chao, Tzu-Ying Sung, Jui-Hua Hsieh, Wei-Jan Huang, Kai-Cheng Hsu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 146, Iss , Pp 112459- (2022)
Chronic inflammation is an underlying cause in a number of diseases. Cyclin-dependent kinase 8 (CDK8) has been implicated as an inflammatory mediator, indicating its potential as an anti-inflammatory target. Herein, we performed structure-based virtu
Externí odkaz:
https://doaj.org/article/0571fe428d584aff829c19f8da7aaa05
Autor:
Tony Eight Lin, Min-Wu Chao, Wei-Chun HuangFu, Huang-Ju Tu, Zhao-Xiang Peng, Chih-Jou Su, Tzu-Ying Sung, Jui-Hua Hsieh, Cheng-Chung Lee, Chia-Ron Yang, Shiow-Lin Pan, Kai-Cheng Hsu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 146, Iss , Pp 112580- (2022)
The dysregulation of DYRK1A is implicated in many diseases such as cancer, diabetes, and neurodegenerative diseases. Alzheimer’s disease is one of the most common neurodegenerative disease and has elevated interest in DYRK1A research. Overexpressio
Externí odkaz:
https://doaj.org/article/bde6aaca1032477f872fda9997782694
Autor:
Huang-Ju Tu, Yi-Jyun Lin, Min-Wu Chao, Ting-Yi Sung, Yi-Wen Wu, Yi-Ying Chen, Mei-Hsiang Lin, Jing-Ping Liou, Shiow-Lin Pan, Chia-Ron Yang
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-13 (2018)
Abstract Background There are some limitations of standard chemotherapy for acute leukemia. Vincristine and doxorubicin are commonly used for acute leukemia, but they may induce serious side effects such as cardiomyopathy and neurotoxicity. Furthermo
Externí odkaz:
https://doaj.org/article/08f7b82eaf5342078ac9c93290b19cec
Autor:
Fang-I Huang, Yi-Wen Wu, Ting-Yi Sung, Jing-Ping Liou, Mei-Hsiang Lin, Shiow-Lin Pan, Chia-Ron Yang
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
In multiple myeloma (MM), homeostasis is largely maintained by misfolded protein clearance via the proteasomal and aggresomal pathways. Histone deacetylase 6 (HDAC6) binds polyubiquitinated proteins and dynein motors and transports this protein cargo
Externí odkaz:
https://doaj.org/article/45e04ed29b93454fb3b01cb9d5a3a7a1
Publikováno v:
Molecules, Vol 25, Iss 23, p 5652 (2020)
Alzheimer’s disease (AD), which is among the most prevalent neurodegenerative diseases, manifests as increasing memory loss and cognitive decline. Tau phosphorylation and aggregation are strongly linked to neurodegeneration, as well as associated w
Externí odkaz:
https://doaj.org/article/3d25351539394a259f5cf4a3cff1a0c3