Výsledky vyhledávání - "Chia-Ping H. Yang"

Total Syntheses of (+)-Peniciketals A-B and (−)-Diocollettines A Exploiting a Photoisomerization/Cyclization Union Protocol

Autor: Chia-Ping H. Yang, Yifan Deng, K. N. Houk, Amos B. Smith, Yike Zou

Publikováno v: J Org Chem
The Journal of organic chemistry, vol 86, iss 19

A late-stage photoisomerization/cyclization union tactic, in conjunction with Type I Anion Relay Chemistry (ARC), permits enantioselective total syntheses and then biological evaluation of (+)-peniciketals A and B. The photochemical protocol was furt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d99e4339bb781597d14a13fb53849123
https://doi.org/10.1021/acs.joc.1c01635

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Enantioselective Total Synthesis of (+)-Peniciketals A and B: Two Architecturally Complex Spiroketals

Autor: Chia-Ping H. Yang, Yifan Deng, Amos B. Smith

Publikováno v: J Am Chem Soc

The enantioselective total syntheses of (+)-peniciketals A and B, two members of a family of architecturally complex spiroketals, have been achieved. Key synthetic transformations comprise Type I Anion Relay Chemistry (ARC) to construct the benzannul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca7aa416efd93de72337b5344944159
https://doi.org/10.1021/jacs.0c11424

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Vulnerability of ARID1A deficient cancer cells to pyrimidine synthesis blockade

Autor: Zhigui Li, Pei Hui, Chia Ping H. Yang, Melissa Schwartz, Oloruntoba Ismail Osagie, Shijun Mi, Gloria S. Huang, Jing Ji

Here we report the discovery and preclinical validation of a novel precision medicine strategy for ARID1A-mutated cancer. Unbiased proteomics reveals for the first time that ARID1A protein (BAF250a) binds aspartate transcarbamoylase (ATCase), a key r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72325d3e6f8a26541a6c89ddc76ec40b
https://doi.org/10.1101/2020.10.12.331975

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Structural basis of microtubule stabilization by discodermolide

Autor: Michel O. Steinmetz, Amos B. Smith, Ian Paterson, Katja Bargsten, Chia Ping H. Yang, Andrea E. Prota, Mariano Redondo-Horcajo, Hayley M. McDaid, José Fernando Díaz, Susan Band Horwitz

Publikováno v: Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
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5 p.-4 fig.-1 schem.
Microtubule-stabilizing agents (MSAs) are widely used in chemotherapy. Here, using X-ray crystallography we describe the detailed binding modes of two potent MSAs, (+)-discodermolide (DDM) and the DDM-paclitaxel-hybrid KS-1-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f63e1967db3081293a6bd58faf960c41
http://hdl.handle.net/10261/243916

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Abstract LB-066: Proteomic-based senescent biomarker identification and characterization in non-small cell lung cancer

Autor: Meagan Vogt, Hayley M. McDaid, Chia-Ping H. Yang, Kenny Ye, Edward Nieves, Steven M. Keller, Perry R. Cohen

Publikováno v: Cancer Research. 76:LB-066

There is widespread interest in the relationship between aging and cancer, and the involvement of senescence in both processes. The accumulation of senescent cells imparts elevated risk of age-associated disease, including cancer; however, a continui

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c95fe0092b74ae6f81bd72c570ed17cd
https://doi.org/10.1158/1538-7445.am2016-lb-066

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Abstract 1229: The next-generation taxanes, SB-T-1214 and SB-CST-10202, exhibit distinct inhibitory effects on photolabeling of β-tubulin from different eukaryotic sources

Autor: Chia-Ping H. Yang, Iwao Ojima, Susan Band Horwitz, Changwei Wang

Publikováno v: Cancer Research. 76:1229-1229

Next-generation taxanes are known to be active against taxane-resistant cell lines that overexpress P-glycoprotein (P-gp) and/or βIII-tubulin, both of which are associated with drug resistance. In this study, we examined the effect of two potent nex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9faa97d98188ce65d19412ee4a2b636
https://doi.org/10.1158/1538-7445.am2016-1229

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Characterization of a human βV-tubulin antibody and expression of this isotype in normal and malignant human tissue

Autor: Alicia Rodriguez-Gabin, Hayley M. McDaid, Suzan K. Chao, Yihong Wang, Lingling Liu, Susan Band Horwitz, Chia Ping H. Yang, Pascal Verdier-Pinard

Publikováno v: Cytoskeleton (Hoboken, N.J.). 69(8)

There are seven distinct β-tubulin isotypes and eight α-tubulin isotypes in mammals that are hypothesized to have tissue- and cell-specific functions. There is an interest in the use of tubulin isotypes as prognostic markers of malignancy. βV-tubu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd63c13c435c70aeb56bff7911cda33
https://pubmed.ncbi.nlm.nih.gov/22903939

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Posttranslational Modifications of Tubulin

Autor: Susan Band Horwitz, Suzan K. Chao, Chia Ping H. Yang

Publikováno v: Cytoskeleton and Human Disease ISBN: 9781617797873

Recent studies have highlighted the potential importance of posttranslational modifications of tubulin in dictating response to antitumor drugs and disease progression. These modifications include glutamylation, glycylation, phosphorylation, acetylat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea9f5d32b624eacee60a6d7c2d8bd362
https://doi.org/10.1007/978-1-61779-788-0_13

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Reversal of the human and murine multidrug-resistance phenotype with megestrol acetate

Autor: Chia Ping H. Yang, Lotte Wang, Pamela A. Trail, Anna Maria Casazza, Susan Band Horwitz

Publikováno v: Cancer Chemotherapy and Pharmacology. 34:96-102

MA is an orally active PG derivative with an excellent safety profile that is used primarily for the treatment of carcinomas of the breast and endometrium. We investigated the potential application of MA as an MDR-reversal agent using cell culture an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84f827685cda6c053ad23d681175e752
https://doi.org/10.1007/bf00685925

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Abstract 833: Photolabeling of β-tubulin isotypes by radiolabeled 2-(m-azidobenzoyl)taxol

Autor: Hui Xiao, Susan Band Horwitz, Chia-Ping H. Yang

Publikováno v: Cancer Research. 74:833-833

There are seven β-tubulin isotypes present in distinct quantities in cells of different origin. Altered expression of β-tubulin isotypes were found in cells resistant to microtubule stabilizing agents (MSAs), such as Taxol, epothilone B, ixabepilon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e2e7a80588ba6146fb24c09f3fcd2f50
https://doi.org/10.1158/1538-7445.am2014-833

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