Endocytic Trafficking of Nanoparticles Delivered by Cell-penetrating Peptides Comprised of Nona-arginine and a Penetration Accelerating Sequence.

Autor: Betty R Liu, Shih-Yen Lo, Chia-Chin Liu, Chia-Lin Chyan, Yue-Wern Huang, Robert S Aronstam, Han-Jung Lee

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e67100 (2013)

Cell-penetrating peptides (CPPs) can traverse cellular membranes and deliver biologically active molecules into cells. In this study, we demonstrate that CPPs comprised of nona-arginine (R9) and a penetration accelerating peptide sequence (Pas) that

Externí odkaz: https://doaj.org/article/d3262a2b75c244fcbc7d34f1fb1bf3f8

Structure of the Complex between a Heparan Sulfate Octasaccharide and Mycobacterial Heparin-Binding Hemagglutinin

Autor: Shu-Yi Lin, Cheng-Po Cheng, Shih-Han Lain, Tzu-Jui Tai, Medel Manuel L. Zulueta, Chwan-Deng Hsiao, Ping-Xi Tsai, Chia-Lin Chyan, Zhi-Geng Chen, Chiao-Chu Ku, Teng-Yi Huang, Shang-Cheng Hung, Deli Irene

Publikováno v: Angewandte Chemie. 129:4256-4260

Heparin-binding hemagglutinin (HBHA) is a 199 amino acid virulence factor at the envelope of Mycobacterium tuberculosis that contributes to latent tuberculosis. The binding of HBHA to respiratory epithelial cells, which leads to extrapulmonary dissem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2722a1f1b55acc3e3f337019d142e040
https://doi.org/10.1002/ange.201612518

The Recognition of Calmodulin to the Target Sequence of Calcineurin—A Novel Binding Mode

Autor: Deli Irene, Chia-Lin Chyan, Sin-Mao Lin

Publikováno v: Molecules; Volume 22; Issue 10; Pages: 1584
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules, Vol 22, Iss 10, p 1584 (2017)

Calcineurin (CaN) is a Ca2+/calmodulin-dependent Ser/Thr protein phosphatase, which plays essential roles in many cellular and developmental processes. CaN comprises two subunits, a catalytic subunit (CaN-A, 60 kDa) and a regulatory subunit (CaN-B, 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f8d42aade9d7ad64d523bbc77d0614

Binding orientation and specificity of calmodulin to rat olfactory cyclic nucleotide-gated ion channel

Autor: Ta Hsien Lin, Feng Yin Li, Jason T.C. Tzen, Chia-Lin Chyan, Tse Yu Chung, Jian Wen Huang, Deli Irene

Publikováno v: Journal of Biomolecular Structure and Dynamics. 31:414-425

Calmodulin (CaM), the primary intracellular Ca(2+) receptor, regulates a large number of key enzymes and controls a wide spectrum of important biological responses. Recognition between CaM and its target sequence in rat olfactory cyclic nucleotide-ga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ff3208a7989cd7f7884f272a6c20b70
https://doi.org/10.1080/07391102.2012.703069

α-Glycosylation by d-Glucosamine-Derived Donors: Synthesis of Heparosan and Heparin Analogues That Interact with Mycobacterial Heparin-Binding Hemagglutinin

Autor: Ya-Ting Lin, Zhonghao Shi, Medel Manuel L. Zulueta, Tsung-I Tsai, Shang-Cheng Hung, Chun-Chih Wang, Deli Irene, Chi-Huey Wong, Shu-Yi Lin, Yu-Peng Hu, Chiao-Chu Ku, Chia-Lin Chyan, Liang-Hin Lim, Susan D. Arco, Ching-Jui Huang

Publikováno v: Journal of the American Chemical Society. 134:8988-8995

Numerous biomolecules possess α-D-glucosamine as structural component. However, chemical glycosylations aimed at this backbone are usually not easily attained without generating the unwanted β-isomer. We report herein a versatile approach in afford

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a305a27a10f679fec5f0909e9862a76
https://doi.org/10.1021/ja302640p