Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Chia-Jui Ku"'
Genetic duplication of tissue factor reveals subfunctionalization in venous and arterial hemostasis.
Autor:
Steven J Grzegorski, Yakun Zhao, Catherine E Richter, Chia-Jui Ku, Kari I Lavik, Divyani Paul, James H Morrissey, Jordan A Shavit
Publikováno v:
PLoS Genetics, Vol 18, Iss 11, p e1010534 (2022)
Tissue factor (TF) is an evolutionarily conserved protein necessary for initiation of hemostasis. Zebrafish have two copies of the tissue factor gene (f3a and f3b) as the result of an ancestral teleost fish duplication event (so called ohnologs). In
Externí odkaz:
https://doaj.org/article/4f7a1ba3392947b688cded389ec2a107
Autor:
Hao Pontius, M. Hao, Chia-Jui Ku, Osmond, Matthew J., Disharoon, Dante, Yang Liu, Warnock, Mark, Lawrence, Daniel A., Marr, David W. M., Neeves, Keith B., Shavit, Jordan A.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 3/5/2024, Vol. 121 Issue 10, p1-6, 8p
Autor:
Sharon A. Singh, Yu Wang, Lei Yu, Takashi Moriguchi, Chia Jui Ku, Julien Pedron, Masayuki Yamamoto, Michael G. Rosenfeld, John H. Bushweller, Greggory Myers, Natee Jearawiriyapaisarn, James Douglas Engel, Rami Khoriaty, Andrew White, Kim-Chew Lim, Emily Schneider
Publikováno v:
Blood. 138:1691-1704
Histone H3 lysine 4 methylation (H3K4Me) is most often associated with chromatin activation, and removing H3K4 methyl groups has been shown to be coincident with gene repression. H3K4Me demethylase KDM1a/LSD1 is a therapeutic target for multiple dise
Publikováno v:
The Journal of Immunology. 201:3465-3470
Allelic exclusion is a vital mechanism for the generation of monospecificity to foreign Ags in B and T lymphocytes. In this study, we developed a high-throughput barcoded method to simultaneously analyze the VDJ recombination status of both mouse TCR
Autor:
Emily Schneider, Andrew White, Yv Wang, Takashi Moriguchi, Kim-Chew Lim, James Douglas Engel, John H. Bushweller, Chia Jui Ku, Julien Pedron, Michael G. Rosenfeld, Natee Jearawiriyapaisarn, Sharon A. Singh, Lei Yu, Greggory Myers, Masayuki Yamamoto, Rami Khoriaty
Histone H3 lysine 4 methylation (H3K4Me) is proximally associated with chromatin activation, and therefore removing H3K4 methyl groups is normally coincident with gene repression. H3K4Me demethylase KDM1a/LSD1 is a potential therapeutic target for mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ceb36d58223d2124967452c4d6031439
https://doi.org/10.1101/2021.01.13.426552
https://doi.org/10.1101/2021.01.13.426552
Publikováno v:
Blood. 136:22-22
Hemostasis is a natural protective process that developed to retain a circulating blood system, conferred by a complicated yet sophisticated balance of factors. Disturbances of this network result in thrombosis or hemorrhage. Among many well-characte
Autor:
Chia Jui Ku, Sakie Ohmura, Mary Hermann, Satoru Takahashi, Tomonori Hosoya, Hisashi Oishi, James Douglas Engel, Seiya Mizuno
Publikováno v:
The journal of clinical investigation. 126(3):865-878
The transcription factor GATA3 is essential for the genesis and maturation of the T cell lineage, and GATA3 dysregulation has pathological consequences. Previous studies have shown that GATA3 function in T cell development is regulated by multiple si
Allelic exclusion is a vital mechanism for the generation of monospecificity to foreign antigens in B- and T-lymphocytes. Here we developed a high-throughput barcoded method to simultaneously analyze the VDJ recombination status of both mouse T cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7cf3668c0155e5bfd4be912fa65c828
https://doi.org/10.1101/320614
https://doi.org/10.1101/320614
Autor:
Yiran Liu, Cher Sha, Qing Wang, Mark Y. Chiang, Tomasz Cierpicki, Nancy Pinnell, Noah F. Garber, Ivy T. Tran, Qingqing Wu, Yitong Chen, Anna C. McCarter, Ivan Maillard, Yeonjoo Oh, Ran Yan, Rork Kuick, Amparo Serna Alarcon, Chia Jui Ku, James Douglas Engel
Publikováno v:
Blood. 132(12)
Notch1 signaling must elevate to high levels in order to drive the proliferation of CD4(−)CD8(−) double-negative (DN) thymocytes and progression to the CD4(+)CD8(+) double-positive (DP) stage through β-selection. During this critical phase of pr
Autor:
James Douglas Engel, Ivan Maillard, Sundeep Kalantry, Kim Chew Lim, Chia Jui Ku, Tomonori Hosoya
Publikováno v:
Genes & Development. 29:1930-1941
Protein abundance must be precisely regulated throughout life, and nowhere is the stringency of this requirement more evident than during T-cell development: A twofold increase in the abundance of transcription factor GATA3 results in thymic lymphoma