Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Chia-Ju Hsieh"'
Autor:
Evan Gallagher, Catherine Hou, Yi Zhu, Chia-Ju Hsieh, Hsiaoju Lee, Shihong Li, Kuiying Xu, Patrick Henderson, Rea Chroneos, Malkah Sheldon, Shaipreeah Riley, Kelvin C. Luk, Robert H. Mach, Meagan J. McManus
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4943 (2024)
The synucleinopathies are a diverse group of neurodegenerative disorders characterized by the accumulation of aggregated alpha-synuclein (aSyn) in vulnerable populations of brain cells. Oxidative stress is both a cause and a consequence of aSyn aggre
Externí odkaz:
https://doaj.org/article/c59213b146d047009a174ab8480e3fb6
Autor:
Chia-Ju Hsieh, Catherine Hou, Yi Zhu, Ji Youn Lee, Neha Kohli, Evan Gallagher, Kuiying Xu, Hsiaoju Lee, Shihong Li, Meagan J. McManus, Robert H. Mach
Publikováno v:
EJNMMI Research, Vol 13, Iss 1, Pp 1-9 (2023)
Externí odkaz:
https://doaj.org/article/993d43f6deb4414c8a047530c4269507
Autor:
Gui-Long Tian, Chia-Ju Hsieh, Michelle Taylor, Ji Youn Lee, Robert R. Luedtke, Robert H. Mach
Publikováno v:
Molecules, Vol 29, Iss 1, p 123 (2023)
A series of bitopic ligands based on Fallypride with a flexible secondary binding fragment (SBF) were prepared with the goal of preparing a D3R-selective compound. The effect of the flexible linker ((R,S)-trans-2a–d), SBFs ((R,S)-trans-2h–j), and
Externí odkaz:
https://doaj.org/article/e8ef1a369d07496e8e081ac3a472a961
Autor:
Chia-Ju Hsieh, Catherine Hou, Yi Zhu, Ji Youn Lee, Neha Kohli, Evan Gallagher, Kuiying Xu, Hsiaoju Lee, Shihong Li, Meagan J. McManus, Robert H. Mach
Publikováno v:
EJNMMI Research, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Background Oxidative stress is implicated in the pathogenesis of the most common neurodegenerative diseases, such as Alzheimer’s disease (AD). However, tracking oxidative stress in the brain has proven difficult and impeded its use as a bi
Externí odkaz:
https://doaj.org/article/a3b82024f10c4b7c8060ea62d1e48ada
Publikováno v:
Pharmaceuticals, Vol 16, Iss 2, p 317 (2023)
The use of computer-aided drug design (CADD) for the identification of lead compounds in radiotracer development is steadily increasing. Traditional CADD methods, such as structure-based and ligand-based virtual screening and optimization, have been
Externí odkaz:
https://doaj.org/article/c4d10d7205194e4e9f905aa0ac62da49
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 432 (2022)
Previous studies have confirmed that the binding of D3 receptor antagonists is competitively inhibited by endogenous dopamine despite excellent binding affinity for D3 receptors. This result urges the development of an alternative scaffold that is ca
Externí odkaz:
https://doaj.org/article/d4cd25af48e8475d8739776af12441e7
Autor:
Laura N. Puentes, Zsofia Lengyel-Zhand, Ji Youn Lee, Chia-Ju Hsieh, Mark E. Schneider, Kimberly J. Edwards, Kelvin C. Luk, Virginia M.-Y. Lee, John Q. Trojanowski, Robert H. Mach
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Poly (ADP-ribose) (PAR) is a negatively charged polymer that is biosynthesized by Poly (ADP-ribose) Polymerase-1 (PARP-1) and regulates various cellular processes. Alpha-synuclein (αSyn) is an intrinsically disordered protein (IDP) that has been dir
Externí odkaz:
https://doaj.org/article/2deab56410f34193b971dfcf9ccf783e
Autor:
Kuo-Lun Huang, Ing-Tsung Hsiao, Hung-Chou Kuo, Chia-Ju Hsieh, Yu-Chen Hsieh, Yi-Ming Wu, Shiaw-Pyng Wey, Tzu-Chen Yen, Kun-Ju Lin, Chin-Chang Huang
Publikováno v:
Journal of the Formosan Medical Association, Vol 118, Iss 9, Pp 1325-1332 (2019)
Background: Visual association memory test (VAMT) is a brief 6-point cognition test that has been shown to be effective in differentiating Alzheimer's disease (AD) from other types of dementia. This study aimed to investigate the correlation of the V
Externí odkaz:
https://doaj.org/article/efcea1439286435b86d16d28ce4dbcdd
Exploration of Diazaspiro Cores as Piperazine Bioisosteres in the Development of σ2 Receptor Ligands
Autor:
Kuiying Xu, Chia-Ju Hsieh, Ji Youn Lee, Aladdin Riad, Nicholas J. Izzo, Gary Look, Susan Catalano, Robert H. Mach
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8259 (2022)
A series of σ2R compounds containing benzimidazolone and diazacycloalkane cores was synthesized and evaluated in radioligand binding assays. Replacing the piperazine moiety in a lead compound with diazaspiroalkanes and the fused octahydropyrrolo[3,4
Externí odkaz:
https://doaj.org/article/885e6534932e40b1974b435f1678e2ce
Autor:
Robert K. Doot, Jacob G. Dubroff, Joshua S. Scheuermann, Kyle J. Labban, Jenny Cai, Chia-Ju Hsieh, Shihong Li, Hsiaoju Lee, Erin K. Schubert, Catherine Hou, Regan Sheffer, Alexander Schmitz, Kuiying Xu, Robert H. Mach
Publikováno v:
EJNMMI Physics, Vol 5, Iss 1, Pp 1-12 (2018)
Abstract Background [18F]Fluortriopride (FTP) was developed as a dopamine D3-selective radiotracer, thought to be important to neurobiological reward pathways and implicated in drug addiction, Parkinson’s disease, and schizophrenia. Preclinical rad
Externí odkaz:
https://doaj.org/article/c889333eed8045fbbd7ee7a3be611495