Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Chia-Hung Christine Hsiao"'
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101422- (2022)
Summary: Vγ9Vδ2 T cells are non-canonical T cells that use their T cell receptor to detect phosphoantigens bound to the internal domain of the HMBPP receptor (butyrophilin 3/2A1 complex). This protocol describes the expansion and purification of hu
Externí odkaz:
https://doaj.org/article/d78003924caf4ec2b1b8313d5ee12003
Autor:
Khiem Nguyen, Yiming Jin, Matthew Howell, Chia-Hung Christine Hsiao, Andrew J. Wiemer, Olga Vinogradova
Publikováno v:
The Journal of Immunology.
Intracellular binding of small-molecule phospho-Ags to the HMBPP receptor complex in infected cells leads to extracellular detection by T cells expressing the Vγ9Vδ2 TCR, a noncanonical method of Ag detection. The butyrophilin proteins BTN2A1 and B
Autor:
Nicholas A. Lentini, Xueting Huang, Megan A. Schladetsch, Chia-Hung Christine Hsiao, David F. Wiemer, Andrew J. Wiemer
Publikováno v:
Bioorg Med Chem Lett
Bis-amidate derivatives have been viewed as attractive phosphonate prodrug forms because of their straightforward synthesis, lack of phosphorus stereochemistry, plasma stability and nontoxic amino acid metabolites. However, the efficiency of bis-amid
Autor:
Nyema M. Harmon, Michael M. Poe, Xueting Huang, Rohit Singh, Benjamin J. Foust, Chia-Hung Christine Hsiao, David F. Wiemer, Andrew J. Wiemer
Publikováno v:
ACS Med Chem Lett
[Image: see text] Phosphoantigens (pAgs) are small organophosphorus compounds such as (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP) that trigger an immune response. These molecules bind to butyrophilin 3A1 (part of the HMBPP receptor) and act
Publikováno v:
Bioorg Chem
Cell-cleavable protecting groups are an effective tactic for construction of biological probes because such compounds can improve problems with instability, solubility, and cellular uptake. Incorporation of fluorescent groups in the protecting groups
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc329df6dcf0e997bd0fe47287892d79
https://europepmc.org/articles/PMC8387413/
https://europepmc.org/articles/PMC8387413/
Autor:
Chia-Hung Christine Hsiao, Andrew J. Wiemer, Nicholas A. Lentini, George B. Crull, David F. Wiemer
Publikováno v:
ACS Med Chem Lett
[Image: see text] Aryloxy phosphonamidate derivatives of a butyrophilin 3A1 ligand are stimulants of Vγ9 Vδ2 T cells. However, when bonded to an aryl ester and an amine, the phosphorus is stereogenic, and past compounds were studied as racemates. T
Publikováno v:
ChemMedChem
A set of phosphonate prodrugs of a butyrophilin ligand was synthesized and evaluated for plasma stability and cellular activity. The mixed aryl acyloxy esters were prepared either via a standard sequence through the phosphonic acid chloride, or throu
Autor:
Kelly A. Teske, Andrew J. Wiemer, Sherry S Agabiti, Chia-Hung Christine Hsiao, Michael M. Poe, Caroline Liu, Victoria Li
Publikováno v:
J Med Chem
Small-molecule phosphoantigens such as (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate stimulate human Vγ9Vδ2 T cells after binding to the intracellular B30.2 domain of the immune receptor butyrophilin 3 isoform A1 (BTN3A1). To understand the ligand-
Publikováno v:
Cell Chem Biol
The ligand-bound (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP) receptor (BTN3A1 and BTN2A1) is detectable by the T cell receptor (TCR) of Vγ9Vδ2 T cells. Although BTN3A1 binds to phosphoantigens (pAgs), the mechanisms resulting in receptor
Autor:
Nicholas A. Lentini, Nyema M. Harmon, Andrew J. Wiemer, Chia-Hung Christine Hsiao, Michael M Poe, David F. Wiemer, Chloe M. Schroeder, Xueting Huang, Megan A. Schladetsch, Benjamin J. Foust
Publikováno v:
ACS Med Chem Lett
[Image: see text] (E)-4-Hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP) and its phosphonate analogs are potent phosphoantigens. HMBPP contains an (E)-allylic alcohol which interacts with the molecular target BTN3A1 giving an antigenic signal to activ