Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Chia-Hsuan Fu"'
Autor:
Chia-Hsuan Fu, Jason C. You, Carrie Mohila, Robert A. Rissman, Daniel Yoshor, Angela N. Viaene, Jeannie Chin
Publikováno v:
Frontiers in Neurology, Vol 14 (2024)
Epilepsy is a chronic neurological disorder characterized by recurrent seizures, and is often comorbid with other neurological and neurodegenerative diseases, such as Alzheimer's disease (AD). Patients with recurrent seizures often present with cogni
Externí odkaz:
https://doaj.org/article/deb4115eca4f460598369137e8e07432
Autor:
Gary Liu, Emmanouil Froudarakis, Jay M. Patel, Mikhail Y. Kochukov, Brandon Pekarek, Patrick J. Hunt, Mayuri Patel, Kevin Ung, Chia-Hsuan Fu, Juyeong Jo, Hyun-Kyoung Lee, Andreas S. Tolias, Benjamin R. Arenkiel
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The precise cell-type specific role of inhibitory interneurons in regulating sensory responses in the olfactory bulb is not known. Here, the authors report that removing GABAergic inhibition from one layer differentially affects response dynamics of
Externí odkaz:
https://doaj.org/article/3447ca4da8274a90a90b01e142722f89
Autor:
Gabriel S. Stephens, Chia-Hsuan Fu, Corey P. St. Romain, Yi Zheng, Justin J. Botterill, Helen E. Scharfman, Yin Liu, Jeannie Chin
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Seizure incidence is increased in Alzheimer’s disease (AD) patients and mouse models, and treatment with the antiseizure drug levetiracetam improves cognition. We reported that one mechanism by which seizures can exert persistent effects on cogniti
Externí odkaz:
https://doaj.org/article/f8b45f1a5eff45b0b0aaf7df8aadccae
Autor:
Jason C You, Kavitha Muralidharan, Chia-Hsuan Fu, Jin Park, Umberto Tosi, Xiaohong Zhang, Jeannie Chin
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0232241 (2020)
Under physiologic conditions, the dentate gyrus (DG) exhibits exceptionally low levels of activity compared to other brain regions. A sparse activation pattern is observed even when the DG is engaged to process new information; for example, only ~1-3
Externí odkaz:
https://doaj.org/article/bed65c2f7d824b9f8b2de32a0185c26d
Autor:
Brian F. Corbett, Jason C. You, Xiaohong Zhang, Mark S. Pyfer, Umberto Tosi, Daniel M. Iascone, Iraklis Petrof, Anupam Hazra, Chia-Hsuan Fu, Gabriel S. Stephens, Annie A. Ashok, Suzan Aschmies, Lijuan Zhao, Eric J. Nestler, Jeannie Chin
Publikováno v:
Cell Reports, Vol 20, Iss 2, Pp 344-355 (2017)
Alzheimer’s disease (AD) is characterized by cognitive decline and 5- to 10-fold increased seizure incidence. How seizures contribute to cognitive decline in AD or other disorders is unclear. We show that spontaneous seizures increase expression of
Externí odkaz:
https://doaj.org/article/cb35c2278b974e948a4663ea202778b5
Autor:
Chia-Hsuan Fu, Daniel Maxim Iascone, Iraklis Petrof, Anupam Hazra, Xiaohong Zhang, Mark S. Pyfer, Umberto Tosi, Brian F. Corbett, Jingli Cai, Jason Lee, Jin Park, Lorraine Iacovitti, Helen E. Scharfman, Grigori Enikolopov, Jeannie Chin
Publikováno v:
Cell Reports, Vol 27, Iss 13, Pp 3741-3751.e4 (2019)
Summary: Adult hippocampal neurogenesis has been reported to be decreased, increased, or not changed in Alzheimer’s disease (AD) patients and related transgenic mouse models. These disparate findings may relate to differences in disease stage, or t
Externí odkaz:
https://doaj.org/article/c68c105cb2284c3eab73a4511c407eb6
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192508 (2018)
The activity-induced transcription factor ∆FosB has been implicated in Alzheimer's disease (AD) as a critical regulator of hippocampal function and cognition downstream of seizures and network hyperexcitability. With its long half-life (> 1 week),
Externí odkaz:
https://doaj.org/article/1df6898ca9db4869a89d10f06fd69dbc
Autor:
Chia-Hsuan Fu, 傅嘉宣
96
Running an efficient meeting can achieve the goal of the meeting at a low cost with human resources efficiency. The Legislative Yuan is the highest level of legislature of Taiwan. The issues discussed in meetings of the Legislative Yuan, wher
Running an efficient meeting can achieve the goal of the meeting at a low cost with human resources efficiency. The Legislative Yuan is the highest level of legislature of Taiwan. The issues discussed in meetings of the Legislative Yuan, wher
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/16476069353569448027
Autor:
Brian F. Corbett, Jin Park, Rohan Jagirdar, Frederik Seibt, Chia-Hsuan Fu, Jeannie Chin, Michael Beierlein
Publikováno v:
Sci Transl Med
Sleep disruptions promote increases of amyloid β (Aβ) and tau in the brain, and increase Alzheimer’s disease (AD) risk, but the precise mechanisms that give rise to sleep disturbances have yet to be defined. The thalamic reticular nucleus (TRN) i
Autor:
Justin J. Botterill, Yi Zheng, Yin Liu, Chia-Hsuan Fu, Gabriel S. Stephens, Jeannie Chin, Corey P St Romain, Helen E. Scharfman
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Frontiers in Neuroscience
Frontiers in Neuroscience
Seizure incidence is increased in Alzheimer's disease (AD) patients and mouse models, and treatment with the antiseizure drug levetiracetam improves cognition. We reported that one mechanism by which seizures can exert persistent effects on cognition