Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Chia-Hsin Cha"'
Publikováno v:
Food & Nutrition Research; 2023, Vol. 67, p1-14, 14p
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract The effective treatment of breast cancer remains a profound clinical challenge, especially due to drug resistance and metastasis which unfortunately arise in many patients. The transcription inhibitor 5,6-dichloro-1-beta-D-ribofuranosyl-benz
Externí odkaz:
https://doaj.org/article/a23c1da0c58b4b2f821f6d3d0d50d8e4
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
Dengue fever (DF), which is caused by the dengue virus (DENV) and transmitted through Aedes mosquitoes, is well recognized for its systemic manifestations, with its ocular involvement gaining recent attention. We present a case of a 41-year-old Taiwa
Externí odkaz:
https://doaj.org/article/bbfdc73795e9407b97676dc3dacdddd3
Autor:
Hong-Jen Lee, Chien-Feng Li, Diane Ruan, Jiabei He, Emily D. Montal, Sonja Lorenz, Geoffrey D. Girnun, Chia-Hsin Chan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Cancer cells develop specific metabolic adaptations. Here, the authors show that in prostate cancer models, the ubiquitin ligase Hect9 promotes tumor growth by accelerating glucose metabolism via ubiquitination of Hexokinase 2, a central regulator of
Externí odkaz:
https://doaj.org/article/c1e48419d9bc4725802932966b49bd52
Publikováno v:
Toxins, Vol 13, Iss 12, p 873 (2021)
Cardiovascular disease (CVD) is the leading cause of mortality in diabetes mellitus (DM). Immunomodulatory dysfunction is a primary feature of DM, and the emergence of chronic kidney disease (CKD) in DM abruptly increases CVD mortality compared with
Externí odkaz:
https://doaj.org/article/571b9747860647c3805518bc3ee04a9c
Autor:
Chia-Hsin Chang, Wei-Ting Liu, Hui-Chi Hung, Chia-Yu Gean, Hong-Ming Tsai, Chun-Lin Su, Po-Wu Gean
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-10 (2017)
Abstract Background Glioma stem cells (GSCs) contribute to tumor recurrence and drug resistance. This study characterizes the tumorigenesis of CD133+ cells and their sensitivity to pharmacological inhibition. Methods GSCs from human U87 and rat C6 gl
Externí odkaz:
https://doaj.org/article/fa1c8a5bc8974d2da764f730f4aeee18
Publikováno v:
Molecular & Cellular Oncology, Vol 6, Iss 5 (2019)
Our study uncovered that HectH9 drives glycolysis and tumor development by K63-linked ubiquitination of Hexokinase 2 (HK2). This mechanism is critical for HK2 localization to mitochondria for activating HK2’s functions in glycolysis promotion and a
Externí odkaz:
https://doaj.org/article/c9d61ab415f44592a6666405a41b3488
Publikováno v:
The Scientific World Journal, Vol 10, Pp 1001-1015 (2010)
The regulation of cell cycle entry is critical for cell proliferation and tumorigenesis. One of the key players regulating cell cycle progression is the F-box protein Skp2. Skp2 forms a SCF complex with Skp1, Cul-1, and Rbx1 to constitute E3 ligase t
Externí odkaz:
https://doaj.org/article/d80c660b76f847e7bb815f2067f07962
Publikováno v:
Stem Cells International, Vol 2016 (2016)
Cancer stem cell (CSC) has become recognized for its role in both tumorigenesis and poor patient prognosis in recent years. Traditional therapeutics are unable to effectively eliminate this group of cells from the bulk population of cancer cells, all
Externí odkaz:
https://doaj.org/article/f15cba71a37f496ca5ee54d4f328f6ba
Autor:
Chia-Hsin Chang, 張家心
107
Liver receptor homolog-1 (LRH-1), a member of nuclear receptor 5A subfamily (NR5A), regulates steroidogenesis, and involves in bile-acid homeostasis and glucose metabolism in liver. LRH-1 also expresses in breast cancer cells, promoting cell
Liver receptor homolog-1 (LRH-1), a member of nuclear receptor 5A subfamily (NR5A), regulates steroidogenesis, and involves in bile-acid homeostasis and glucose metabolism in liver. LRH-1 also expresses in breast cancer cells, promoting cell
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/kr466p
