Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Chia-Chi Flora Huang"'
Autor:
Jeroen Kneppers, Tesa M. Severson, Joseph C. Siefert, Pieter Schol, Stacey E. P. Joosten, Ivan Pak Lok Yu, Chia-Chi Flora Huang, Tunç Morova, Umut Berkay Altıntaş, Claudia Giambartolomei, Ji-Heui Seo, Sylvan C. Baca, Isa Carneiro, Eldon Emberly, Bogdan Pasaniuc, Carmen Jerónimo, Rui Henrique, Matthew L. Freedman, Lodewyk F. A. Wessels, Nathan A. Lack, Andries M. Bergman, Wilbert Zwart
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Epigenetic reprogramming of the androgen receptor (AR) has been identified as an important process driving prostate cancer (PCa) progression. Here, the authors analyze the role of AR chromatin binding heterogeneity in PCa clinical outcomes, metastasi
Externí odkaz:
https://doaj.org/article/391fd7851a8744c0932eb78127f219b4
Autor:
Chia-Chi Flora Huang, Shreyas Lingadahalli, Tunc Morova, Dogancan Ozturan, Eugene Hu, Ivan Pak Lok Yu, Simon Linder, Marlous Hoogstraat, Suzan Stelloo, Funda Sar, Henk van der Poel, Umut Berkay Altintas, Mohammadali Saffarzadeh, Stephane Le Bihan, Brian McConeghy, Bengul Gokbayrak, Felix Y. Feng, Martin E. Gleave, Andries M. Bergman, Colin Collins, Faraz Hach, Wilbert Zwart, Eldon Emberly, Nathan A. Lack
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-26 (2021)
Abstract Background Androgen receptor (AR) is critical to the initiation, growth, and progression of prostate cancer. Once activated, the AR binds to cis-regulatory enhancer elements on DNA that drive gene expression. Yet, there are 10–100× more b
Externí odkaz:
https://doaj.org/article/f44c462b807b4890bf2fd42d2752fc95
Autor:
Sylvan C. Baca, Cassandra Singler, Soumya Zacharia, Ji-Heui Seo, Tunc Morova, Faraz Hach, Yi Ding, Tommer Schwarz, Chia-Chi Flora Huang, Jacob Anderson, André P. Fay, Cynthia Kalita, Stefan Groha, Mark M. Pomerantz, Victoria Wang, Simon Linder, Christopher J. Sweeney, Wilbert Zwart, Nathan A. Lack, Bogdan Pasaniuc, David Y. Takeda, Alexander Gusev, Matthew L. Freedman
Publikováno v:
Nature genetics, vol 54, iss 9
Nat Genet
Nature Genetics, 54(9), 1364-1375. Nature Publishing Group
Nature Genetics
Nat Genet
Nature Genetics, 54(9), 1364-1375. Nature Publishing Group
Nature Genetics
Many genetic variants affect disease risk by altering context-dependent gene regulation. Such variants are difficult to study mechanistically using current methods that link genetic variation to steady-state gene expression levels, such as expression
Autor:
Wilbert Zwart, Andries M. Bergman, Henk van der Poel, Nathan A. Lack, Lisa M. Butler, Lodewyk F.A. Wessels, Matthew L. Freedman, Amina Zoubeidi, Felix Y. Feng, René H. Medema, Maarten Altelaar, Bogdan Pasaniuc, Ji-Heui Seo, Claudia Giambartolomei, Iris de Rink, Roelof J.C. Kluin, Jeroen de Jong, Dorine C. Hintzen, Anniek Zaalberg, Martin Sjöström, Sylvan C. Baca, Yongsoo Kim, Liesbeth Hoekman, Umut Berkay Altintas, Tunc Morova, Chia-Chi Flora Huang, Joyce Sanders, Tesa M. Severson, Elise M. Bekers, Maartje Alkemade, Hilda de Barros, Karianne Schuurman, Nils Eickhoff, Suzan Stelloo, Marlous Hoogstraat, Simon Linder
Supplementary Figure from Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f42b86f8b15f67e1989e728942677f1
https://doi.org/10.1158/2159-8290.22541192
https://doi.org/10.1158/2159-8290.22541192
Autor:
Wilbert Zwart, Andries M. Bergman, Henk van der Poel, Nathan A. Lack, Lisa M. Butler, Lodewyk F.A. Wessels, Matthew L. Freedman, Amina Zoubeidi, Felix Y. Feng, René H. Medema, Maarten Altelaar, Bogdan Pasaniuc, Ji-Heui Seo, Claudia Giambartolomei, Iris de Rink, Roelof J.C. Kluin, Jeroen de Jong, Dorine C. Hintzen, Anniek Zaalberg, Martin Sjöström, Sylvan C. Baca, Yongsoo Kim, Liesbeth Hoekman, Umut Berkay Altintas, Tunc Morova, Chia-Chi Flora Huang, Joyce Sanders, Tesa M. Severson, Elise M. Bekers, Maartje Alkemade, Hilda de Barros, Karianne Schuurman, Nils Eickhoff, Suzan Stelloo, Marlous Hoogstraat, Simon Linder
In prostate cancer, androgen receptor (AR)–targeting agents are very effective in various disease stages. However, therapy resistance inevitably occurs, and little is known about how tumor cells adapt to bypass AR suppression. Here, we performed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90ac6a409e8171f21c2df0636766df70
https://doi.org/10.1158/2159-8290.c.6549566
https://doi.org/10.1158/2159-8290.c.6549566
Autor:
Wilbert Zwart, Andries M. Bergman, Henk van der Poel, Nathan A. Lack, Lisa M. Butler, Lodewyk F.A. Wessels, Matthew L. Freedman, Amina Zoubeidi, Felix Y. Feng, René H. Medema, Maarten Altelaar, Bogdan Pasaniuc, Ji-Heui Seo, Claudia Giambartolomei, Iris de Rink, Roelof J.C. Kluin, Jeroen de Jong, Dorine C. Hintzen, Anniek Zaalberg, Martin Sjöström, Sylvan C. Baca, Yongsoo Kim, Liesbeth Hoekman, Umut Berkay Altintas, Tunc Morova, Chia-Chi Flora Huang, Joyce Sanders, Tesa M. Severson, Elise M. Bekers, Maartje Alkemade, Hilda de Barros, Karianne Schuurman, Nils Eickhoff, Suzan Stelloo, Marlous Hoogstraat, Simon Linder
Supplementary Data from Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65bc06dbadf0cd7246e380aada412ad4
https://doi.org/10.1158/2159-8290.22541195
https://doi.org/10.1158/2159-8290.22541195
Autor:
Ming-Daw Tsai, Hwei-Fang Tien, Shih-Lan Hsu, Chang-Tze Ricky Yu, Chia-Chi Flora Huang, Hsiang-Chun Su, Ting-Yang Lin, Jo-Mei Maureen Chen, Chih-Ru Lin, Chieh-Lin Jerry Teng, Wen-Chien Chou, Hsin-An Hou, Ting-Jung Wu, Pei-Yu Wu, Tong-You Wade Wei
Aurora A–dependent NF-κB signaling portends poor prognosis in acute myeloid leukemia (AML) and other cancers, but the functional basis underlying this association is unclear. Here, we report that Aurora A is essential for Thr9 phosphorylation of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aafe8ebf0d3ec42743e57bfca870885
https://doi.org/10.1158/0008-5472.c.6508910
https://doi.org/10.1158/0008-5472.c.6508910
Autor:
Ming-Daw Tsai, Hwei-Fang Tien, Shih-Lan Hsu, Chang-Tze Ricky Yu, Chia-Chi Flora Huang, Hsiang-Chun Su, Ting-Yang Lin, Jo-Mei Maureen Chen, Chih-Ru Lin, Chieh-Lin Jerry Teng, Wen-Chien Chou, Hsin-An Hou, Ting-Jung Wu, Pei-Yu Wu, Tong-You Wade Wei
Supplementary Methods - construction of plasmids, synthesis of siRNA, and methods for RT-qPCR. Supplementary Figure Legends - legends for supplementary figures. Supplementary References - references for supplementary methods. Supplementary Figures (S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3db6d2a73b23e4e4510e5f71f3710d
https://doi.org/10.1158/0008-5472.22414190
https://doi.org/10.1158/0008-5472.22414190
Autor:
Mark R. Flory, Gang Chen, Matthew E.K. Chang, Martin E. Gleave, Chia-Chi Flora Huang, Robert N. Young, Nathan A. Lack, Fariba Ghaidi, Hélène Morin, Fuqiang Ban, Shreyas Lingadahalli, Ayse Derya Cavga, Ivan Pak Lok Yu, Sam Lawn, Sankar Mohan, Eric Leblanc, Paul S. Rennie, Nada Lallous, Artem Cherkasov, Hisham Mohammed
Publikováno v:
Journal of Medicinal Chemistry. 64:14968-14982
Prostate cancer (PCa) patients undergoing androgen deprivation therapy almost invariably develop castration-resistant prostate cancer (CRPC). Targeting the androgen receptor (AR) Binding Function-3 (BF3) site offers a promising option to treat CRPC.
Autor:
Eric, Leblanc, Fuqiang, Ban, Ayse Derya, Cavga, Sam, Lawn, Chia-Chi Flora, Huang, Sankar, Mohan, Matthew E K, Chang, Mark R, Flory, Fariba, Ghaidi, Shreyas, Lingadahalli, Gang, Chen, Ivan Pak Lok, Yu, Hélène, Morin, Nada, Lallous, Martin E, Gleave, Hisham, Mohammed, Robert N, Young, Paul S, Rennie, Nathan A, Lack, Artem, Cherkasov
Publikováno v:
Journal of medicinal chemistry. 64(20)
Prostate cancer (PCa) patients undergoing androgen deprivation therapy almost invariably develop castration-resistant prostate cancer (CRPC). Targeting the androgen receptor (AR) Binding Function-3 (BF3) site offers a promising option to treat CRPC.