Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Chia Wei Chou"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract CASTs use both CRISPR-associated proteins and Tn7-family transposons for RNA-guided vertical and horizontal transmission. CASTs encode minimal CRISPR arrays but can’t acquire new spacers. Here, we report that CASTs can co-opt defense-assoc
Externí odkaz:
https://doaj.org/article/87ad148d25754558b864c70a17ead820
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract CRISPR-Cas13d cleaves RNA and is used in vivo and for diagnostics. However, a systematic understanding of its RNA binding and cleavage specificity is lacking. Here, we describe an RNA Chip-Hybridized Association-Mapping Platform (RNA-CHAMP)
Externí odkaz:
https://doaj.org/article/707aad093e864c7e8d26b0eba435ea43
Autor:
Ching-Lin Hsieh, Scott A. Rush, Concepcion Palomo, Chia-Wei Chou, Whitney Pickens, Vicente Más, Jason S. McLellan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The degree to which the conformation of the human metapneumovirus fusion (F) protein affects immunogenicity has been debated. Here, Hsieh et al. engineer prefusion-stabilized F variants with enhanced thermostability that elicit higher neutralizing an
Externí odkaz:
https://doaj.org/article/1881314158b644b685989d8847d72882
Autor:
Ching-Lin Hsieh, Anne P. Werner, Sarah R. Leist, Laura J. Stevens, Ester Falconer, Jory A. Goldsmith, Chia-Wei Chou, Olubukola M. Abiona, Ande West, Kathryn Westendorf, Krithika Muthuraman, Ethan J. Fritch, Kenneth H. Dinnon, III, Alexandra Schäfer, Mark R. Denison, James D. Chappell, Ralph S. Baric, Barney S. Graham, Kizzmekia S. Corbett, Jason S. McLellan
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109929- (2021)
Summary: Current coronavirus (CoV) vaccines primarily target immunodominant epitopes in the S1 subunit, which are poorly conserved and susceptible to escape mutations, thus threatening vaccine efficacy. Here, we use structure-guided protein engineeri
Externí odkaz:
https://doaj.org/article/af2791637eea401ba71a9731ca3cb5c0
Autor:
Luo-Uei Liang, Yu-Hsiung Yen, Chia-Wei Chou, Ko-Hsuan Mandy Chen, Hsiao-Yu Lin, Sheng-Wen Huang, Minghwei Hong, Jueinai Kwo, Germar Hoffmann
Publikováno v:
AIP Advances, Vol 11, Iss 2, Pp 025245-025245-6 (2021)
The physical investigation of surfaces and their properties crucially depends on their quality. Such investigations are commonly performed in an ultra-high vacuum environment. Thereby, the transfer of samples among different setups and under ambient
Externí odkaz:
https://doaj.org/article/4c248d3dff3447839ac5e4bd4846e10f
Autor:
S. Wesley Long, Randall J. Olsen, Paul A. Christensen, David W. Bernard, James J. Davis, Maulik Shukla, Marcus Nguyen, Matthew Ojeda Saavedra, Prasanti Yerramilli, Layne Pruitt, Sishir Subedi, Hung-Che Kuo, Heather Hendrickson, Ghazaleh Eskandari, Hoang A. T. Nguyen, J. Hunter Long, Muthiah Kumaraswami, Jule Goike, Daniel Boutz, Jimmy Gollihar, Jason S. McLellan, Chia-Wei Chou, Kamyab Javanmardi, Ilya J. Finkelstein, James M. Musser
Publikováno v:
mBio, Vol 11, Iss 6 (2020)
ABSTRACT We sequenced the genomes of 5,085 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains causing two coronavirus disease 2019 (COVID-19) disease waves in metropolitan Houston, TX, an ethnically diverse region with 7 million res
Externí odkaz:
https://doaj.org/article/9f1850b41a7e45ea80ff416602d5d71c
Statins are 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors broadly used for the control of hypercholesterolemia. Recently, they are reported to have beneficial effects on certain cancers. In this study, we show that statins inhibited the histone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca14005578ee95e17b129171520ee9f1
https://doi.org/10.1158/0008-5472.c.6497528
https://doi.org/10.1158/0008-5472.c.6497528
Supplementary Figures 1-2 from Statins Increase p21 through Inhibition of Histone Deacetylase Activity and Release of Promoter-Associated HDAC1/2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7dde8d12bb9a91539d14e3fb63fdb22
https://doi.org/10.1158/0008-5472.22374644.v1
https://doi.org/10.1158/0008-5472.22374644.v1
Publikováno v:
bioRxiv
Type VI CRISPR enzymes cleave target RNAs and are widely used for gene regulation, RNA tracking, and diagnostics. However, a systematic understanding of their RNA binding specificity and cleavage activation is lacking. Here, we describeRNAchip-hybrid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c2a5c2ef2d1c4b36f118c61a89edfa9
https://doi.org/10.1101/2023.03.27.534188
https://doi.org/10.1101/2023.03.27.534188
CRISPR-associated transposons (CASTs) have co-opted CRISPR-Cas proteins and Tn7-family transposons for RNA-guided vertical and horizontal transmission. CASTs encode minimal CRISPR arrays but lack all spacer acquisition genes. Here, we define how diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce5e35ba47d4afa6f68f18d56e684a00
https://doi.org/10.1101/2023.03.03.531003
https://doi.org/10.1101/2023.03.03.531003