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Efg1 Involved in Drug Resistance by Regulating the Expression of ERG3 in Candida albicans

Autor: Yu-Tai Ching, Chia Li Su, Jang Shiun Wang, Chia Geun Chen, Chia Tung Hsu, Ting Yin Hsiao, Hsiu-Jung Lo, Ming-Ji Fann, Chih Yang Lin, Yun-Liang Yang

Publikováno v: Antimicrobial Agents and Chemotherapy. 49:1213-1215

The ERG3 gene in Candida albicans was identified as a gene whose mRNA level was higher in the cph1 / cph1 efg1 / efg1 double mutant than in the wild-type cells. Further study showed that Efg1, but not Cph1, negatively regulated ERG3 . Mutations in EF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51154b4dd0b5979a051e5b6ab81dec8b
https://doi.org/10.1128/aac.49.3.1213-1215.2005

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Aβ40(L17A/F19A) mutant diminishes the aggregation and neurotoxicity of Aβ40

Autor: Chih Ching Wang, Ta Hsien Lin, Yi Ru Chen, Chi Jen Lo, Yi Chen Chen, Hsin Tzu Liu, Ming-Shi Shiao, Chia Li Su, Hsien-Bin Huang

Publikováno v: Biochemical and biophysical research communications. 405(1)

Aggregated β-amyloid peptides (Aβ) are neurotoxic and responsible for neuronal death both in vitro and in vivo. From the structural point of view, Aβ self-aggregation involves a conformational change in the peptide. Here, we investigated the relat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::166849548a0d4db6c06c2397facc841e
https://pubmed.ncbi.nlm.nih.gov/21216230

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Functional characterization of the microtubule-binding and -destabilizing domains of CPAP and d-SAS-4

Autor: Yulin Chang, Tang K. Tang, Chia Li Su, Liang Yi Hung, Chieh Ju C. Tang, Wen Bin Hsu

Publikováno v: Experimental cell research. 314(14)

We previously identified a novel centrosomal protein CPAP, which carries a 112-residue motif that is essential for microtubule destabilization. In this report, we define both the microtubule (MT) binding and destabilizing domains in human CPAP and an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2bd71d89e4f2ea9cde7daed5abcdef8
https://pubmed.ncbi.nlm.nih.gov/18586240

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CaNdt80 Is Involved in Drug Resistance in Candida albicans by Regulating CDR1

Autor: Yun-Liang Yang, Chia-Geun Chen, Hsin-I Shih, Chia-Li Su, Hsiu-Jung Lo

Overexpression of CDR1 , an efflux pump, is one of the major mechanisms contributing to drug resistance in Candida albicans. CDR1 p-lacZ was constructed and transformed into a Saccharomyces cerevisiae strain so that the lacZ gene could be used as the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb3a848a76323852166442295fca6e21
https://europepmc.org/articles/PMC529242/

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