Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Chia Chung Lee"'
Autor:
Chun-Liang Chen, Tsung-Chih Chen, Chia-Chung Lee, Liu-Chuan Shih, Chih-Yuan Lin, Ying-Yu Hsieh, Ahmed Atef Ahmed Ali, Hsu-Shan Huang
Publikováno v:
Arabian Journal of Chemistry, Vol 12, Iss 8, Pp 3503-3516 (2019)
A series of 3-substituted-4-chloro-thioxanthones and their corresponding S,S-dioxidethioxanthone derivatives were designed and synthesized. The effects of our synthesized compounds on cell viability toward the MCF-7 and MDA-MB-468 breast cancer cell
Externí odkaz:
https://doaj.org/article/ef18afc796484d03a10cdedc8ba1c8b0
Autor:
Tsung-Chih Chen, Jih-Hwa Guh, Hui-Wen Hsu, Chun-Liang Chen, Chia-Chung Lee, Chia-Lun Wu, Yu-Ru Lee, Jing-Jer Lin, Dah-Shyong Yu, Hsu-Shan Huang
Publikováno v:
Arabian Journal of Chemistry, Vol 12, Iss 8, Pp 2864-2881 (2019)
Several anthrapyrazolone derivatives derived from 7-chloroanthra[1,9-cd]pyrazol-6(2H)-one and 7-chloro-2-(2-hydroxyethyl)anthra[1,9-cd] pyrazol-6(2H)-one have been prepared by the addition or substitution nucleophilic reactions and further transforme
Externí odkaz:
https://doaj.org/article/07c8dfd9976e42c8b028a480878eaa79
Autor:
Tsung-Chih Chen, Dah-Shyong Yu, Shiag-Jiun Chen, Chun-Liang Chen, Chia-Chung Lee, Ying-Yu Hsieh, Lien-Cheng Chang, Jih-Hwa Guh, Jing-Jer Lin, Hsu-Shan Huang
Publikováno v:
Arabian Journal of Chemistry, Vol 12, Iss 8, Pp 4348-4364 (2019)
Several 9-chloro-11H-indeno[1,2-c]quinolin-11-one derivatives have been designed which is replacing side chains with different groups containing oxygen, nitrogen or sulfur atoms. Substitution of C-6 on the starting structure, 6,9-dichloro-11H-indeno[
Externí odkaz:
https://doaj.org/article/d45f804a2ed94bd5bebf658de88326e6
Autor:
Chia-Chung Lee, Yang Lo, Ling-Jun Ho, Jenn-Haung Lai, Shiu-Bii Lien, Leou-Chyr Lin, Chun-Liang Chen, Tsung-Chih Chen, Feng-Cheng Liu, Hsu-Shan Huang
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0149317 (2016)
As part of an effort to profile potential therapeutics for the treatment of inflammation-related diseases, a diversity of amide-linked small molecules was synthesized by using parallel synthesis strategy. Moreover, these new compounds were also evalu
Externí odkaz:
https://doaj.org/article/ff0cd08f1cee4ecb85907756ec01f6a9
Autor:
Ahmed Atef Ahmed Ali, Yu-Ru Lee, Tsung-Chih Chen, Chun-Liang Chen, Chia-Chung Lee, Chia-Yang Shiau, Chiao-Hsi Chiang, Hsu-Shan Huang
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0154278 (2016)
The novel compounds NSC745885 and NSC757963 developed at our laboratory were tested against a panel of 60 cancer cell lines at the National Cancer Institute, USA, and a panel of 39 cancer cell lines at the Japanese Foundation of Cancer Research. Both
Externí odkaz:
https://doaj.org/article/0762edb391c748a1886cb9bef57c843d
Autor:
Yu Ling Tsai, Chung Yao Wu, Hsu Shan Huang, Yu-Juei Hsu, Kuo Feng Hua, Chih Yu Yang, Chih Yu Hsieh, Jia Feng Chan, Ann Chen, Chia-Chao Wu, Chia Chung Lee, Feng Cheng Liu, Chih Jun Wan, Debabrata Mukhopadhyay, Shuk-Man Ka, Jui Chun Weng, Shin Ruen Yang
Publikováno v:
FASEB J
In the present study, acute onset of severe lupus nephritis was successfully treated in mice using a new, benzamide-linked, small molecule that targets immune modulation and the NLRP3 inflammasome. Specifically, 6-(2,4-difluorophenyl)-3-(3-(trifluoro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5919f7a6023ae7ac935ca69ec70a9354
https://doi.org/10.1096/fj.202100047r
https://doi.org/10.1096/fj.202100047r
Autor:
Te-Yu Lin, Jeng-Wei Lu, Hsu Shan Huang, Shiu Bii Lien, Zhiyuan Gong, Yi Jung Ho, Min Chung Shen, Feng Cheng Liu, Jenn Haung Lai, Leou Chyr Lin, Ling-Jun Ho, Liv Weichien Chen, Chia Chung Lee
Publikováno v:
Biochemical and Biophysical Research Communications. 517:155-163
Osteoarthritis (OA) is a common degenerative joint disease characterized by progressive deterioration of articular cartilage. There have been reports that small molecule inhibitors have anti-osteoarthritis effects; however, the effects of 3-(4-chloro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::887cef8defdecbcfa9d58dcd5740c175
https://doi.org/10.1016/j.bbrc.2019.07.036
https://doi.org/10.1016/j.bbrc.2019.07.036
Autor:
Yu-Ru Lee, Dah-Shyong Yu, Ya-Chun Liang, Kuo-Feng Huang, Shih-Jie Chou, Tsung-Chih Chen, Chia-Chung Lee, Chun-Liang Chen, Shih-Hwa Chiou, Hsu-Shan Huang
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56284 (2013)
Poly (ADP-ribose) polymerase-1 (PARP-1) and telomerase, as well as DNA damage response pathways are targets for anticancer drug development, and specific inhibitors are currently under clinical investigation. The purpose of this work is to evaluate a
Externí odkaz:
https://doaj.org/article/10af16a9c8b34d98b1185f56e0e3705b
Publikováno v:
Phytomedicine : international journal of phytotherapy and phytopharmacology. 69
Background Areca nut has anti-inflammatory, antiparasitic, antihypertensive, and antidepressant properties. The pathological hallmarks of inflammatory joint diseases are an increased number of osteoclasts and impaired differentiation of osteoblasts,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98284cf066c6fc66328c3070dffd4c72
https://pubmed.ncbi.nlm.nih.gov/32200293
https://pubmed.ncbi.nlm.nih.gov/32200293
Autor:
Deh-Ming Chang, Chun Liang Chen, Hsu Shan Huang, Ahmed Atef Ahmed Ali, Chia Chung Lee, Fei Lan Liu, Tsung Chih Chen
Publikováno v:
European Journal of Medicinal Chemistry. 117:70-84
Inhibiting osteoclastogenesis is a promising therapeutic target for treating osteoclast-related diseases. Herein, we synthesized a series of modified salicylanilides and their corresponding 3-phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-dione and 10-phenyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c49dbb83559f1e19dc7d1ff8ae33c70
https://doi.org/10.1016/j.ejmech.2016.04.007
https://doi.org/10.1016/j.ejmech.2016.04.007