Zobrazeno 1 - 10
of 253
pro vyhledávání: '"Chia‐Chen Liu"'
Publikováno v:
BMC Nursing, Vol 23, Iss 1, Pp 1-12 (2024)
Abstract Background Meeting people’s needs is positively correlated with their recovery. However, recovery services rarely include nurse-led programs tailored to the needs of these people. This study aimed to evaluate the effectiveness of a new nee
Externí odkaz:
https://doaj.org/article/e2f96d48aa194ac59eeb3ab350923e62
Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer’s disease
Autor:
Ana-Caroline Raulin, Sydney V. Doss, Michael G. Heckman, Emily C. Craver, Zonghua Li, Tadafumi C. Ikezu, Hiroaki Sekiya, Chia-Chen Liu, Yuka A. Martens, Cassandra L. Rosenberg, Lindsey A. Kuchenbecker, Michael DeTure, R. Ross Reichard, Aivi T. Nguyen, Eleni Constantopoulos, Rachel A. Larsen, Emmaline K. Kounaves, Melissa E. Murray, Dennis W. Dickson, Ronald C. Petersen, Guojun Bu, Takahisa Kanekiyo
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Alzheimer’s disease (AD), characterized by the deposition of amyloid-β (Aβ) in senile plaques and neurofibrillary tangles of phosphorylated tau (pTau), is increasingly recognized as a complex disease with multiple pathologies. AD sometim
Externí odkaz:
https://doaj.org/article/8f5535e35e724bf6989bb41e302e114e
Autor:
Lei Guo, Jiqing Cao, Jianwei Hou, Yonghe Li, Min Huang, Li Zhu, Larry Zhang, Yeji Lee, Mariana Lemos Duarte, Xianxiao Zhou, Minghui Wang, Chia-Chen Liu, Yuka Martens, Michael Chao, Alison Goate, Guojun Bu, Vahram Haroutunian, Dongming Cai, Bin Zhang
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-25 (2023)
Abstract Background Alzheimer’s disease (AD) is a progressive and age-associated neurodegenerative disorder that affects women disproportionally. However, the underlying mechanisms are poorly characterized. Moreover, while the interplay between sex
Externí odkaz:
https://doaj.org/article/d883bf15b9474573b841d4c12f05c16a
Autor:
Wenhui Qiao, Yixing Chen, Jun Zhong, Benjamin J. Madden, Cristine M. Charlesworth, Yuka A. Martens, Chia-Chen Liu, Joshua Knight, Tadafumi C. Ikezu, Aishe Kurti, Yiyang Zhu, Axel Meneses, Cassandra L. Rosenberg, Lindsey A. Kuchenbecker, Lucy K. Vanmaele, Fuyao Li, Kai Chen, Francis Shue, Maxwell V. Dacquel, John Fryer, Akhilesh Pandey, Na Zhao, Guojun Bu
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-22 (2023)
Abstract Background The rare p.H157Y variant of TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) was found to increase Alzheimer’s disease (AD) risk. This mutation is located at the cleavage site of TREM2 extracellular domain. Ectopic expre
Externí odkaz:
https://doaj.org/article/aeb26e05f9954b82bf1169b444687ab2
Autor:
Stephanie R. Oatman, Joseph S. Reddy, Zachary Quicksall, Minerva M. Carrasquillo, Xue Wang, Chia-Chen Liu, Yu Yamazaki, Thuy T. Nguyen, Kimberly Malphrus, Michael Heckman, Kristi Biswas, Kwangsik Nho, Matthew Baker, Yuka A. Martens, Na Zhao, Jun Pyo Kim, Shannon L. Risacher, Rosa Rademakers, Andrew J. Saykin, Michael DeTure, Melissa E. Murray, Takahisa Kanekiyo, for the Alzheimer’s Disease Neuroimaging Initiative, Dennis W. Dickson, Guojun Bu, Mariet Allen, Nilüfer Ertekin-Taner
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-23 (2023)
Abstract Background Alzheimer’s disease (AD) is neuropathologically characterized by amyloid-beta (Aβ) plaques and neurofibrillary tangles. The main protein components of these hallmarks include Aβ40, Aβ42, tau, phosphor-tau, and APOE. We hypoth
Externí odkaz:
https://doaj.org/article/1d652f0071c94e8798dfc22c9ad7f41e
Autor:
Na Wang, Minghui Wang, Suren Jeevaratnam, Cassandra Rosenberg, Tadafumi C. Ikezu, Francis Shue, Sydney V. Doss, Alla Alnobani, Yuka A. Martens, Melissa Wren, Yan W. Asmann, Bin Zhang, Guojun Bu, Chia-Chen Liu
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-20 (2022)
Abstract Background Abnormal lipid accumulation has been recognized as a key element of immune dysregulation in microglia whose dysfunction contributes to neurodegenerative diseases. Microglia play essential roles in the clearance of lipid-rich cellu
Externí odkaz:
https://doaj.org/article/c84dad3190d44dd7b5898869d241cadf
Autor:
Ana-Caroline Raulin, Sydney V. Doss, Zachary A. Trottier, Tadafumi C. Ikezu, Guojun Bu, Chia-Chen Liu
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-26 (2022)
Abstract Alzheimer’s disease (AD) is the most common cause of dementia worldwide, and its prevalence is rapidly increasing due to extended lifespans. Among the increasing number of genetic risk factors identified, the apolipoprotein E (APOE) gene r
Externí odkaz:
https://doaj.org/article/e0b56cbf47db45da8937c2f737339784
Autor:
Kai Chen, Yuka A. Martens, Axel Meneses, Daniel H. Ryu, Wenyan Lu, Ana Caroline Raulin, Fuyao Li, Jing Zhao, Yixing Chen, Yunjung Jin, Cynthia Linares, Marshall Goodwin, Yonghe Li, Chia-Chen Liu, Takahisa Kanekiyo, David M. Holtzman, Todd E. Golde, Guojun Bu, Na Zhao
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-14 (2022)
Abstract Background The aggregation and spread of α-synuclein (α-Syn) protein and related neuronal toxicity are the key pathological features of Parkinson’s disease (PD) and Lewy body dementia (LBD). Studies have shown that pathological species o
Externí odkaz:
https://doaj.org/article/6cbd01c19d96474d84a60117d4afbc0d
Autor:
Hiroshi Oue, Yu Yamazaki, Wenhui Qiao, Chen Yuanxin, Yingxue Ren, Aishe Kurti, Francis Shue, Tammee M. Parsons, Ralph B. Perkerson, Keiji Kawatani, Ni Wang, Skylar C. Starling, Bhaskar Roy, Ioana-Emilia Mosneag, Tomonori Aikawa, Marie-Louise Holm, Chia-Chen Liu, Yasuteru Inoue, Patrick M. Sullivan, Yan W. Asmann, Betty Y.S. Kim, Guojun Bu, Takahisa Kanekiyo
Publikováno v:
JCI Insight, Vol 8, Iss 7 (2023)
Cerebrovasculature is critical in maintaining brain homeostasis; its dysregulation often leads to vascular cognitive impairment and dementia (VCID) during aging. VCID is the second most prevalent cause of dementia in the elderly, after Alzheimer’s
Externí odkaz:
https://doaj.org/article/3982980e6d7948619fd5c5933bf5242e
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 101976- (2023)
Summary: Cholesterol is a structural component of cell membranes. Most cells are incapable of its catabolism, and intracellular cholesterol accumulation is linked to several disorders including cardiovascular and neurodegenerative diseases. Cholester
Externí odkaz:
https://doaj.org/article/65c6493c6aeb4cd1a7de79a2116660d8