Pseudo-temporal dynamics of chemoresistant triple negative breast cancer cells reveal EGFR/HER2 inhibition as synthetic lethal during mid-neoadjuvant chemotherapy

Autor: Song, Won-Min, Chia, Pei-Ling, Zhou, Xianxiao, Walsh, Martin, Silva, Jose, Zhang, Bin

Publikováno v: In iScience 17 February 2023 26(2)

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Network-based assessment of HDAC6 activity predicts preclinical and clinical responses to the HDAC6 inhibitor ricolinostat in breast cancer.

Autor: Zeleke TZ; Graduate School, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA., Pan Q; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Chiuzan C; Feinstein Institutes for Medical Research, Northwell Health, New York, USA., Onishi M; Genentech, South San Francisco, CA, USA., Li Y; Departments of Structural Biology and Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA., Tan H; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA., Alvarez MJ; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; DarwinHealth, Inc., New York, NY, USA., Honan E; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA., Yang M; Acetylon Pharmaceuticals, Boston, MA, USA., Chia PL; Graduate School, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA., Mukhopadhyay P; Graduate School, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA., Kelly S; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA., Wu R; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA., Fenn K; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA., Trivedi MS; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA., Accordino M; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA., Crew KD; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA., Hershman DL; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA., Maurer M; Bristol-Myers Squibb, Princeton, NJ, USA., Jones S; Regenacy Pharmaceuticals, Inc., Waltham, MA, USA., High A; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA., Peng J; Departments of Structural Biology and Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA., Califano A; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA., Kalinsky K; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA. kevin.michael.kalinsky@emory.edu., Yu J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA. jiyang.yu@stjude.org., Silva J; Department of Pathology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA. jose.silva@mssm.edu.

Publikováno v: Nature cancer [Nat Cancer] 2023 Feb; Vol. 4 (2), pp. 257-275. Date of Electronic Publication: 2022 Dec 30.