Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Chi-Wai Do"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
IntroductionMultifactorial Eye disorders are a significant public health concern and have a huge impact on quality of life. The pathophysiological mechanisms underlying these eye disorders were not completely understood since functional and low-throu
Externí odkaz:
https://doaj.org/article/9213f434ac1f459e876e9dcb31e23a1c
Autor:
Li Pan, Kin-Sang Cho, Xin Wei, Fuyi Xu, Anton Lennikov, Guangan Hu, Jing Tang, Shuai Guo, Julie Chen, Emil Kriukov, Robert Kyle, Farris Elzaridi, Shuhong Jiang, Pierre A. Dromel, Michael Young, Petr Baranov, Chi-Wai Do, Robert W. Williams, Jianzhu Chen, Lu Lu, Dong Feng Chen
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112889- (2023)
Summary: Microglia shift toward an inflammatory phenotype during aging that is thought to exacerbate age-related neurodegeneration. The molecular and cellular signals that resolve neuroinflammation post-injury are largely undefined. Here, we exploit
Externí odkaz:
https://doaj.org/article/55ab54bc0ed043058de1e9df498fb842
Autor:
Jacky M. K. Kwong, Joseph Caprioli, Joanne C. Y. Lee, Yifan Song, Feng-Juan Yu, Jingfang Bian, Ying-Hon Sze, King-Kit Li, Chi-Wai Do, Chi-Ho To, Thomas Chuen Lam
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12109 (2023)
To explore the temporal profile of retinal proteomes specific to primary and secondary retinal ganglion cell (RGC) loss. Unilateral partial optic nerve transection (pONT) was performed on the temporal side of the rat optic nerve. Temporal and nasal r
Externí odkaz:
https://doaj.org/article/9560e817a73547ba8bc73e0bf0282db5
Autor:
Ka-Lok Li, Sze-Wan Shan, Fang-Yu Lin, Choi-Ying Ling, Nga-Wai Wong, Hoi-Lam Li, Wei Han, Chi-Ho To, Chi-Wai Do
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5789 (2023)
Secretion of melatonin, a natural hormone whose receptors are present in the ciliary epithelium, displays diurnal variation in the aqueous humor (AH), potentially contributing to the regulation of intraocular pressure. This study aimed to determine t
Externí odkaz:
https://doaj.org/article/5b37ae5412a14bd78e2792ff4e2205c3
Autor:
Li Pan, Ying Hon Sze, Menglu Yang, Jing Tang, Siming Zhao, Irvin Yi, Chi-Ho To, Chuen Lam, Dong Feng Chen, Kin-Sang Cho, Chi-Wai Do
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Retinal ischemia is a common cause of many retinal diseases, leading to irreversible vision impairment and blindness. Excessive neuroinflammation, including microglial activation and T-cell responses, has been identified as a critical factor associat
Externí odkaz:
https://doaj.org/article/8f6104c1c9ee4ebda62e5da25c8ddd16
Autor:
Hoi-lam Li, Sze Wan Shan, W. Daniel Stamer, King-kit Li, Henry Ho-lung Chan, Mortimer M. Civan, Chi-ho To, Thomas Chuen Lam, Chi-wai Do
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7372 (2022)
Elevated intraocular pressure (IOP) is a major risk factor for glaucoma that results from impeded fluid drainage. The increase in outflow resistance is caused by trabecular meshwork (TM) cell dysfunction and excessive extracellular matrix (ECM) depos
Externí odkaz:
https://doaj.org/article/26c35e8fa7df4d3c965d575e752eef29
Publikováno v:
Data in Brief, Vol 31, Iss , Pp 105846- (2020)
Rho-associated coiled coil-forming protein kinase (ROCK) inhibitors represent a novel class of anti-glaucoma drugs because of their ocular hypotensive effects. However, the underlying mechanisms responsible for lowering intraocular pressure (IOP) are
Externí odkaz:
https://doaj.org/article/7997925d92c0497d9def750f6f0afd7e
Publikováno v:
Cell Transplantation, Vol 27 (2018)
Glaucoma, a form of progressive optic neuropathy, is the second leading cause of blindness worldwide. Being a prominent disease affecting vision, substantial efforts are being made to better understand glaucoma pathogenesis and to develop novel treat
Externí odkaz:
https://doaj.org/article/d4b08e1dc5a84d899049bd2a97898907
Publikováno v:
Frontiers in Molecular Biosciences; 2024, p1-30, 30p
Autor:
Geoffrey C. H. Chu, Lily Y. L. Chan, Chi-wai Do, Andy C. Y. Tse, Teris Cheung, Grace P. Y. Szeto, Billy C. L. So, Regina L. T. Lee, Paul H. Lee
Publikováno v:
Environmental Science and Pollution Research. 30:58428-58435
Prolonged electronic screen use can cause digital eye strain. It can be difficult to rectify due to increasing smartphone reliance, potentially leading to serious public health problems. To investigate the association between time spent on smartphone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d2787df08c62ba78fc5a1452b5b8b90
https://doi.org/10.1007/s11356-023-26258-0
https://doi.org/10.1007/s11356-023-26258-0