Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Chi-Sung Chiu"'
Autor:
I‐Ming Wang, Bin Zhang, Xia Yang, Jun Zhu, Serguei Stepaniants, Chunsheng Zhang, Qingying Meng, Mette Peters, Yudong He, Chester Ni, Deborah Slipetz, Michael A Crackower, Hani Houshyar, Christopher M Tan, Ernest Asante‐Appiah, Gary O'Neill, Mingjuan Jane Luo, Rolf Thieringer, Jeffrey Yuan, Chi‐Sung Chiu, Pek Yee Lum, John Lamb, Yves Boie, Hilary A Wilkinson, Eric E Schadt, Hongyue Dai, Christopher Roberts
Publikováno v:
Molecular Systems Biology, Vol 8, Iss 1, Pp 1-16 (2012)
Abstract Common inflammatome gene signatures as well as disease‐specific signatures were identified by analyzing 12 expression profiling data sets derived from 9 different tissues isolated from 11 rodent inflammatory disease models. The inflammatom
Externí odkaz:
https://doaj.org/article/7f8736e3694946c78134d40fac8a24ec
Autor:
Jiaqiang Cai, Bimjhana Bishwokarma, Dennis Leung, William J. Morris, Feroze Ujjainwalla, Candice Alleyne, Xiaoxing Du, Vincent J. Colandrea, Jennifer Piesvaux, Jianwu Bai, Liming Yang, Carla Alpert, Joseph M. Metzger, Vincenzo Pucci, Xiaofang Li, Jeffrey J. Hale, Dominique Stickens, Weiguo Quan, Byron G. DuBois, Rongqiang Liu, Mark Zielstorff, Chi-Sung Chiu, Christopher Joseph Sinz, Mangeng Cheng, Kallol Ray, Liping Wang, Ping Liu, Stella H. Vincent, Alejandro Crespo
Publikováno v:
ACS Medicinal Chemistry Letters. 9:1193-1198
[Image: see text] We report herein the design and synthesis of a series of orally active, liver-targeted hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitors for the treatment of anemia. In order to mitigate the concerns for potential sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76215d13beffa00c0fc7a79f728fdec
https://doi.org/10.1021/acsmedchemlett.8b00274
https://doi.org/10.1021/acsmedchemlett.8b00274
Autor:
John Miao, Belma Dogdas, Francisco Cruz, Gain M. Robinson, Amy Vanko, Robert Faltus, Kalyan Chakravarthy, Dahai Xue, Chi-Sung Chiu, Mark Zielstorff, Donald V. Conway, Weisheng Zhang, Kimberly A. Bettano, Joe Zhu, Shubing Wang, Milenko Cicmil, Lily Y. Moy, Raquel S. Sevilla, Erica Leccese
Publikováno v:
Bone. 73:32-41
Rheumatoid arthritis (RA) is a chronic autoimmune disease resulting in joint inflammation, pain, and eventual bone loss. Bone loss and remodeling caused by symmetric polyarthritis, the hallmark of RA, is readily detectable by bone mineral density (BM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3607b859e5ef8c19b40b23be9af25d
Autor:
Peter J. Dandliker, Hao Tang, Christopher J. Dinsmore, Chi-Sung Chiu, Fiona Elwood, Deborah Slipetz, Jennifer Piesvaux, Sujal V. Deshmukh, Ilona Kariv, Bo-Sheng Pan, Carla Alpert, Nathan Bays, Alan Byford, Alexey Rivkin, Peter Goldenblatt, Irena Ivanovska, Mark E. Scott, Joel A. Klappenbach, Hyun-Hee Lee, David J. Witter, Kalyan Chakravarthy, Lauren Dorosh, Yujie Qu, Brian Kraybill, Mark Zielstorff
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 361(2)
Reversible janus associated kinase (JAK) inhibitors such as tofacitinib and decernotinib block cytokine signaling and are efficacious in treating autoimmune diseases. However, therapeutic doses are limited due to inhibition of other JAK/signal transd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30dcce0e8183db5060a7c6ebeec57fe3
https://pubmed.ncbi.nlm.nih.gov/28193636
https://pubmed.ncbi.nlm.nih.gov/28193636
Autor:
Kalyan Chakravarthy, Hilary A. Wilkinson, Sharon Adamski, Abhishek Kulkarni, Albert Rauch, Chi-Sung Chiu, Stephen E. Alves, Claus Bendtsen, Belma Dogdas, Gary S. Kath, Hans Weber
Publikováno v:
Journal of Applied Physiology. 112:2087-2098
Age-related sarcopenia results in frailty and decreased mobility, which are associated with increased falls and long-term disability in the elderly. Given the global increase in lifespan, sarcopenia is a growing, unmet medical need. This report aims
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca885a05b9b913db05e4e4e2a907d4a
https://doi.org/10.1152/japplphysiol.00871.2011
https://doi.org/10.1152/japplphysiol.00871.2011
Publikováno v:
Computerized Medical Imaging and Graphics. 35:616-628
Skeletal muscles consist of muscle fibers that are responsible for contracting and generating force. Skeletal muscle fibers are categorized into distinct subtypes based on several characteristics such as contraction time, force production and resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91176c8fd45d8ad2f4b1c303fa46fce
https://doi.org/10.1016/j.compmedimag.2011.01.009
https://doi.org/10.1016/j.compmedimag.2011.01.009
Autor:
Clare Leech, Edward M. Scolnick, Jonathan Schneeweis, Chi-Sung Chiu, Wei Zheng, Philip E. Brandish, Berta Strulovici, Oleg Kornienko, Nicholas J. Brandon
Publikováno v:
SLAS Discovery. 11:481-487
Enzymes are often considered less "druggable" targets than ligand-regulated proteins such as G-protein-coupled receptors, ion channels, or other hormone receptors. Reasons for this include cellular location (intracellular vs. cell surface), typically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba0c34f35af2e6114e9f12cba393f5e1
https://doi.org/10.1177/1087057106288181
https://doi.org/10.1177/1087057106288181
Autor:
Rosa L. Fradley, E.J. Armstrong, Chi-Sung Chiu, R.B. Heavens, Nicholas J. Brandon, A.R. Rutter, Richard J. Newman, R. Konno, Peter H. Hutson, Sarah Almond
Publikováno v:
Molecular and Cellular Neuroscience. 32:324-334
d -Amino acid oxidase (DAO) degrades d -serine, a co-agonist at the NMDA receptor (NMDAR). Hypofunction of the NMDAR has been suggested to contribute to the pathophysiology of schizophrenia. Intriguingly, DAO has been recently identified as a risk fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc405a31bafee41e1a6a2dbce01ed2d
https://doi.org/10.1016/j.mcn.2006.05.003
https://doi.org/10.1016/j.mcn.2006.05.003
Autor:
Shuli Zhang, Dana A. Stoffregen, Anwar Murtaza, Mark Zielstorff, Weisheng Zhang, Jie Zhang-Hoover, Erica Leccese, Michael Caniga, Robert Faltus, Milenko Cicmil, Lily Y. Moy, John H. Shin, SuChun Hseih, Raquel S. Sevilla, Chi-Sung Chiu, Gain M. Robinson, Kalyan Chakravarthy, Robbie L. McLeod, Alan Byford
Publikováno v:
BMC Musculoskeletal Disorders
Background The impact of anti-TNF, corticosteroid and analgesic therapy on inflammation and pain was evaluated in a novel mono-arthritic multi-flare rat Streptococcal Cell Wall (SCW) model using Etanercept, Dexamethasone and Buprenorphine. Methods Mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e61363f56f35788b58ee6945901996
https://doi.org/10.1186/1471-2474-15-409
https://doi.org/10.1186/1471-2474-15-409
Autor:
Chi-Sung Chiu, Ping Lu, Cyrille Sur, David J. Figueroa, Yuan Liu, Thomas M. Connolly, Ken S. Koblan, Nan Wei, Ann-Marie Lawlor, Menghang Xia
Publikováno v:
Molecular Brain Research. 125:96-104
d -serine is present in the mammalian central nervous system, where it acts as one of the co-activators of N-methyl-D aspartate receptors. Synthesis of d -serine is catalyzed by the serine racemase enzyme. The current studies report on the isolation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac2fa777008b5bd7544af5b4c3b3d24c
https://doi.org/10.1016/j.molbrainres.2004.03.007
https://doi.org/10.1016/j.molbrainres.2004.03.007