Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Chi-Ming C. Lee"'
Autor:
Edward P. Vacek, Thomas Michael Bare, Martin C. Dyroff, Kathy L. Neilson, Rebecca Urbanek, J. Empfield, Alan S. Kirschner, Christine Barlaam, Joseph Lewis, Chi-Ming C. Lee, Wenhua Xiao, Megan Murphy, Vernon Alford, Janet Marie Forst, Gary Steelman, Shephali Trivedi, Richard A. Keith, Frances M. Mclaren, Dean G. Brown, Keith John Herzog, Horchler Carey
Publikováno v:
Journal of Medicinal Chemistry. 50:3113-3131
A series of 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5H)-triones were synthesized and found to have potent activity at the glycine site of the NMDA receptor. In some cases, these compounds possessed poor aqueous s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e6df439ce03cdca255c44c5222f7a4
https://doi.org/10.1021/jm060212s
https://doi.org/10.1021/jm060212s
Autor:
Dean G. Brown, Kathy L. Neilson, Horchler Carey, Thomas Michael Bare, Frances M. Mclaren, Gary Steelman, James Empfield, Richard A. Keith, Martin C. Dyroff, Wenhua Xiao, Rebecca Urbanek, Janet Marie Forst, Chi-Ming C. Lee, Shephali Trivedi, Keith John Herzog, Megan Murphy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3553-3556
Several members of the 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5H)-triones (2) have been identified as being potent and selective NMDA glycine-site antagonists. Increasing size of the alkyl substituent on the alp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5c094ed082aa4e657e79b5ec88d0a5
https://doi.org/10.1016/s0960-894x(03)00750-9
https://doi.org/10.1016/s0960-894x(03)00750-9
Autor:
Thomas M. Bare, Dean G. Brown, Carey L. Horchler, Megan Murphy, Rebecca A. Urbanek, Vernon Alford, Christine Barlaam, Martin C. Dyroff, James B. Empfield, Janet M. Forst, Keith J. Herzog, Richard A. Keith, Alan S. Kirschner, Chi-Ming C. Lee, Joseph Lewis, Frances M. McLaren, Kathy L. Neilson, Gary B. Steelman, Shephali Trivedi, Edward P. Vacek
Publikováno v:
Journal of Medicinal Chemistry; Jun2007, Vol. 50 Issue 13, p3113-3131, 19p