Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Chi-Lu Chiu"'
Autor:
Ernie Yulyaningsih, Jung H Suh, Melania Fanok, Roni Chau, Hilda Solanoy, Ryan Takahashi, Anna I Bakardjiev, Isabel Becerra, N Butch Benitez, Chi-Lu Chiu, Sonnet S Davis, William E Dowdle, Timothy Earr, Anthony A Estrada, Audrey Gill, Connie Ha, Patrick CG Haddick, Kirk R Henne, Martin Larhammar, Amy W-S Leung, Romeo Maciuca, Bahram Memarzadeh, Hoang N Nguyen, Alicia A Nugent, Maksim Osipov, Yingqing Ran, Kevin Rebadulla, Elysia Roche, Thomas Sandmann, Jing Wang, Joseph W Lewcock, Kimberly Scearce-Levie, Lesley A Kane, Pascal E Sanchez
Publikováno v:
eLife, Vol 12 (2024)
The integrated stress response (ISR) is a conserved pathway in eukaryotic cells that is activated in response to multiple sources of cellular stress. Although acute activation of this pathway restores cellular homeostasis, intense or prolonged ISR ac
Externí odkaz:
https://doaj.org/article/6521500dd1424027bebffc6920eba56b
Autor:
Annie Arguello, René Meisner, Elliot R. Thomsen, Hoang N. Nguyen, Ritesh Ravi, Jeffrey Simms, Iris Lo, Jessica Speckart, Julia Holtzman, Thomas M. Gill, Darren Chan, Yuhsiang Cheng, Chi-Lu Chiu, Jason C. Dugas, Meng Fang, Isabel A. Lopez, Hilda Solanoy, Buyankhishig Tsogtbaatar, Yuda Zhu, Akhil Bhalla, Kirk R. Henne, Anastasia G. Henry, Anthony Delucchi, Simona Costanzo, Jeffrey M. Harris, Dolores Diaz, Kimberly Scearce-Levie, Pascal E. Sanchez
Publikováno v:
JCI Insight, Vol 6, Iss 19 (2021)
Mucopolysaccharidosis type II (MPS II) is a lysosomal storage disorder caused by deficiency of the iduronate-2-sulfatase (IDS) enzyme, resulting in cellular accumulation of glycosaminoglycans (GAGs) throughout the body. Treatment of MPS II remains a
Externí odkaz:
https://doaj.org/article/7257efca6a4647a28c441e395328432c
Autor:
Yulyaningsih, Ernie, Suh, Jung H., Fanok, Melania, Chau, Roni, Solanoy, Hilda, Takahashi, Ryan, Bakardjiev, Anna I., Becerra, Isabel, Benitez, N. Butch, Chi-Lu Chiu, Davis, Sonnet S., Dowdle, William E., Earr, Timothy, Estrada, Anthony A., Gill, Audrey, Ha, Connie, Haddick, Patrick C. G., Henne, Kirk R., Larhammar, Martin, Leung, Amy W-S.
Publikováno v:
eLife; 9/17/2024, p1-32, 32p
Autor:
Michael T. Maloney, Xiang Wang, Rajarshi Ghosh, Shan V. Andrews, Romeo Maciuca, Shababa T. Masoud, Richard M. Caprioli, John Chen, Chi-Lu Chiu, Sonnet S. Davis, Audrey Cheuk-Nga Ho, Hoang N. Nguyen, Nicholas E. Propson, Michelle L. Reyzer, Oliver B. Davis, Matthew C. Deen, Sha Zhu, Gilbert Di Paolo, David J. Vocadlo, Anthony A. Estrada, Javier de Vicente, Joseph W. Lewcock, Annie Arguello, Jung H. Suh, Sarah Huntwork-Rodriguez, Anastasia G. Henry
Lysosomal dysfunction is a hallmark of Parkinson’s disease (PD), and variants in several PD-associated genes, includingLRRK2, perturb lysosomal homeostasis. Based on this, LRRK2 kinase inhibition is being explored as a therapeutic approach for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc13473cd36348881c86cb13ff023e4d
https://doi.org/10.1101/2022.12.19.521070
https://doi.org/10.1101/2022.12.19.521070
Autor:
Ryan J. Watts, Kathryn M. Monroe, Junhua Wang, Melina Lenser, Jennifer Hsiao-Nakamoto, Hoang Nguyen, Todd P. Logan, Do Jin Kim, Fen Huang, Ritesh Ravi, Gilbert Di Paolo, Anil Rana, Kannan Gunasekaran, Yaneth Robles-Colmenares, Gerald M. Cherf, Buyankhishig Tsogtbaatar, Ceyda Llapashtica, Kirk R. Henne, Hilda Solanoy, Pascal E. Sanchez, Yashas Rajendra, Mihalis Kariolis, Ray Lieh Yoon Low, Roni Chau, Laralynne Przybyla, Michelle E. Pizzo, Chi-Lu Chiu, Meng Fang, Anastasia G. Henry, Giuseppe Astarita, Mark S. Dennis, Adam L. Boxer, Sarah L. DeVos, Sonnet S. Davis, Hilary W. Heuer, René Meisner, Joseph W. Lewcock, Devendra B. Srivastava, Bradley F. Boeve, Meredith E. K. Calvert, Katrina W. Lexa, Rachel Prorok, Lukas L. Skuja, Dolores Diaz, Akhil Bhalla, Matthew Simon, Jung H. Suh, Ankita Srivastava, Timothy K. Earr, Howard J. Rosen, Joseph Duque, Bettina Van Lengerich, Elizabeth W. Sun
Publikováno v:
Cell
Cell, vol 184, iss 18
Cell, vol 184, iss 18
GRN mutations cause frontotemporal dementia (GRN-FTD) due to deficiency in progranulin (PGRN), a lysosomal and secreted protein with unclear function. Here, we found that Grn(−/−) mice exhibit a global deficiency in bis(monoacylglycero)phosphate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e8760616b55660b5a69ea73b7ad6da
https://europepmc.org/articles/PMC8489356/
https://europepmc.org/articles/PMC8489356/
Autor:
Ritesh Ravi, Annie Arguello, Sonnet S. Davis, Chi-Lu Chiu, Yuda Zhu, Junhua Wang, Dolores Diaz, Hoang N. Nguyen, Jeffrey M. Harris, Meng Fang, Jessica R. Blumenfeld, Damian Fiore, Timothy K. Earr, Matthew D. Troyer, Heather Cahan, Akhil Bhalla, Maria L. Escolar, Kimberly Scearce-Levie, Giuseppe Astarita
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 5188, p 5188 (2020)
Volume 21
Issue 15
International Journal of Molecular Sciences, Vol 21, Iss 5188, p 5188 (2020)
Volume 21
Issue 15
Mucopolysaccharidosis type II is a lysosomal storage disorder caused by a deficiency of iduronate-2-sulfatase (IDS) and characterized by the accumulation of the primary storage substrate, glycosaminoglycans (GAGs). Understanding central nervous syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f45c3656bedb3bb0388c10fd2d610e
https://pubmed.ncbi.nlm.nih.gov/32707880
https://pubmed.ncbi.nlm.nih.gov/32707880
Autor:
Morgan A. Darrow, Mingyi Chen, Arta M. Monjazeb, Chin-Shang Li, Robert J. Canter, Timothy Henderson, Chi Lu Chiu, William J. Murphy
Publikováno v:
Journal of Surgical Research. 223:207-214
BackgroundCancer stem cells (CSCs) have been shown to resist chemotherapy and promote metastasis after cytotoxic therapies. We sought to determine if the expression of CSC markers (aldehyde dehydrogenase [ALDH], CD44, and epidermal growth factor rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f185dd712ed1dd5b2887a62bc358f596
https://doi.org/10.1016/j.jss.2017.11.016
https://doi.org/10.1016/j.jss.2017.11.016
Autor:
Karen Kelly, David T. Cooke, Megan E. Daly, Elizabeth A. David, Joy Melnikow, Lisa M. Brown, Chi-Lu Chiu, Chin-Shang Li, Robert J. Canter
Publikováno v:
Journal of Thoracic Oncology. 12:437-445
Introduction Variation in treatment and survival outcomes for NSCLC is high among patients with stage III or IV disease, but patients with untreated NSCLC have not been critically analyzed to evaluate for improvable outcomes. We evaluated treatment t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70db51727a552cdda965c187489d48cd
https://doi.org/10.1016/j.jtho.2016.11.2221
https://doi.org/10.1016/j.jtho.2016.11.2221
Autor:
Sonnet S. Davis, Jeffrey M. Harris, Heather Cahan, Hoang N. Nguyen, Meng Fang, Junhua Wang, Akhil Bhalla, Annie Arguello, Dolores Diaz, Giuseppe Astarita, Chi-Lu Chiu, Jessica R. Blumenfeld, Timothy K. Earr, Damian Fiore, Maria L. Escolar, Kimberly Scearce-Levie, Matthew D. Troyer, Ritesh Ravi, Yuda Zhu
Publikováno v:
Molecular Genetics and Metabolism. 132:S20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9044999358ce59478c7c6ba0fcf4e172
https://doi.org/10.1016/j.ymgme.2020.12.027
https://doi.org/10.1016/j.ymgme.2020.12.027
Autor:
Akhil Bhalla, Jessica Speckart, Pascal E. Sanchez, Buyankhishig Tsogtbaatar, Yuda Zhu, Julia Holtzman, Anastasia G. Henry, Elliot R. Thomsen, Dolores Diaz, Kimberly Scearce-Levie, Ritesh Ravi, Yuhsiang Cheng, Meng Fang, Jeffrey M. Harris, Hilda Solanoy, Annie Arguello, Hoang N. Nguyen, Michael Gill, Matthew D. Troyer, Jeffrey Simms, Simona Costanzo, Anthony Delucchi, René Meisner, Chi-Lu Chiu
Publikováno v:
Molecular Genetics and Metabolism. 132:S16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f27cc142958ed85c83169d4080339a5
https://doi.org/10.1016/j.ymgme.2020.12.015
https://doi.org/10.1016/j.ymgme.2020.12.015