Výsledky vyhledávání - "Chi-Kong Chan"

Akademický článek

Aristolochic Acids: Newly Identified Exposure Pathways of this Class of Environmental and Food-Borne Contaminants and its Potential Link to Chronic Kidney Diseases

Autor: Chi-Kong Chan, Yushuo Liu, Nikola M. Pavlović, Wan Chan

Publikováno v: Toxics, Vol 7, Iss 1, p 14 (2019)

Aristolochic acids (AAs) are nitrophenanthrene carboxylic acids naturally produced by Aristolochia plants. These plants were widely used to prepare herbal remedies until AAs were observed to be highly nephrotoxic and carcinogenic to humans. Although

Externí odkaz: https://doaj.org/article/f5d813cc27f04227a469f3e32f64979a

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Polyurethane Foam Face Masks as a Dosimeter for Quantifying Personal Exposure to Airborne Volatile and Semi-Volatile Organic Compounds

Autor: Zhihan Sun, Wanlin Guo, Chi-Kong Chan, Long Jin, Stephen M. Griffith, Jian Zhen Yu, Wan Chan

Publikováno v: Chemical Research in Toxicology. 35:1604-1613

Airborne volatile organic compounds (VOCs) and semi-volatile organic compounds (SVOCs) are commonly quantitated by collecting the analytes on solid sorbent tubes or passive air samplers, followed by solvent extraction and instrumental analysis, or by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e048cb2400a7665933e0cd9c0225408
https://doi.org/10.1021/acs.chemrestox.2c00205

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Determination of Aristolochic Acids in Vegetables: Nephrotoxic and Carcinogenic Environmental Pollutants Contaminating a Broad Swath of the Food Supply and Driving Incidence of Balkan Endemic Nephropathy

Autor: Chun-Kit Au, Nikola Pavlović, Jiayin Zhang, Wan Chan, Jing Yao, Cui Li, Chi-Kong Chan, Guorui Liu

Publikováno v: Chemical Research in Toxicology. 33:2446-2454

Balkan endemic nephropathy (BEN) is a slowly progressive interstitial fibrotic disease affecting numerous people living along the Danube River in the Balkan Peninsula, of which aristolochic acids (AAs) produced naturally in Aristolochia plants are ke

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8510fa8fa62693d03cbab1f61596913d
https://doi.org/10.1021/acs.chemrestox.0c00229

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Identifying Cysteine, N-Acetylcysteine, and Glutathione Conjugates as Novel Metabolites of Aristolochic Acid I: Emergence of a New Detoxification Pathway

Autor: Wan Chan, Jiayin Zhang, Yat Hing Ham, Chi-Kong Chan

Publikováno v: Chemical Research in Toxicology. 33:1374-1381

There is accumulating evidence that Balkan endemic nephropathy (BEN) is an environmental disease caused by aristolochic acids (AAs) released from the decomposition of Aristolochia clematitis L., an AA-containing weed that grows abundantly in the Balk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a53671bf74966830fd9b9c017009f13
https://doi.org/10.1021/acs.chemrestox.9b00488

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Occurrence and Environmental Stability of Aristolochic Acids in Groundwater Collected from Serbia: Links to Human Exposure and Balkan Endemic Nephropathy

Autor: Guorui Liu, Kwan-Kit Jason Chan, Wan Chan, Nikola Pavlović, Yao Zhao, Chi-Kong Chan, Ka-Ki Tung

Publikováno v: Environmental Science & Technology. 54:1554-1561

Aristolochic acids (AAs) have been known as potent nephrotoxins since the use of AA-containing herbal medicines was linked with a series of sporadic renal fibrotic nephropathy cases, and yet an estimated 100 million people worldwide are still at risk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f242788dee67e3bed6d777e4c7194bff
https://doi.org/10.1021/acs.est.9b05337

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Quantitation of N6-Formyl-lysine Adduct Following Aristolochic Acid Exposure in Cells and Rat Tissues by Liquid Chromatography-Tandem Mass Spectrometry Coupled with Stable Isotope-Dilution Method

Autor: Chi-Kong Chan, K. K. Jason Chan, Yao Zhao, Wan Chan

Publikováno v: Chemical Research in Toxicology. 32:2086-2094

N6-Formyl-lysine (FLys) is an abundant and lasting protein adduct formed when formaldehyde generated by nitrosative/oxidative stress and inflammation reacts with lysine residues. It is believed that the post-translational N6-formylation of lysine is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59250cf4ecb4e66156deec6a062f3761
https://doi.org/10.1021/acs.chemrestox.9b00272

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Development of a novel liquid chromatography-tandem mass spectrometric method for aristolochic acids detection: Application in food and agricultural soil analyses

Autor: Wan Chan, Chi-Kong Chan, Nikola Pavlović

Publikováno v: Food Chemistry. 289:673-679

Prolonged dietary exposure to AA-contaminated food crops cultivated in contaminated farmland was shown to be one of the main culprits of Balkan endemic nephropathy. Ultra-sensitive methods for the detection of AA at trace levels are important for sur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88797a039cb3edbc181f9ee0dc293eac
https://doi.org/10.1016/j.foodchem.2019.03.073

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