Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Chi-Keung Wan"'
Autor:
Warren J. Leonard, Chi-Keung Wan
Publikováno v:
F1000Research, Vol 5 (2016)
IL-21 is a type I cytokine produced by T cells and natural killer T cells that has pleiotropic actions on a wide range of immune and non-immune cell types. Since its discovery in 2000, extensive studies on the biological actions of IL-21 have been pe
Externí odkaz:
https://doaj.org/article/aa8e200a13864449afffcda58e183221
Publikováno v:
The Journal of Immunology. 196:543-546
IL-1β is a proinflammatory cytokine important for local and systemic immunity. However, aberrant production of this cytokine is implicated in pathogenic mechanisms of a number of inflammatory diseases, including Behçet’s disease and age-related m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7dbbc1706cb97ecfc32a04c1d96cb271
https://doi.org/10.4049/jimmunol.1502080
https://doi.org/10.4049/jimmunol.1502080
Autor:
Chi-Keung Wan, Majid Kazemian, Steven M. Holland, Alexandra F. Freeman, Warren J. Leonard, Jangsuk Oh, Phillip A. Swanson, Allison B. Andraski, Leigh Samsel, Joshua D. Milner, Dorian B. McGavern, Elizabeth P. Sampaio, Rosanne Spolski, Peng Li
Publikováno v:
Proceedings of the National Academy of Sciences. 112:9394-9399
Significance IL-21 is a type I cytokine important for immune cell differentiation and function. We found that transcription factors STAT1 and STAT3 play partially opposing roles in IL-21 function in CD4 + T cells. Both STAT1 and STAT3 control IL-21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde2afac40f667433b4866d8f202bd5e
https://doi.org/10.1073/pnas.1511711112
https://doi.org/10.1073/pnas.1511711112
Autor:
Zhi-Ling Yu, Anfernee Kai-Wing Tse, Chi-Keung Wan, Guo-Yuan Zhu, Hui Wang, David Wang Fun Fong
Publikováno v:
Phytomedicine. 17:702-705
We studied the effects of schisandrol A (SCH) and gomisin A (GOM), two of the main bioactive components of Fructus Schisandrae chinensis, on cytochrome P450-3A4 (CYP3A4) activity and cellular glutathione (GSH) level. In a cell-free system both SCH an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64dfc2fe204738e8c0c757daf4b631f7
https://doi.org/10.1016/j.phymed.2009.12.005
https://doi.org/10.1016/j.phymed.2009.12.005
Autor:
Guo-Yuan Zhu, Zhi-Ling Yu, Chi-Keung Wan, Anfernee Kai-Wing Tse, Xiao-Ling Shen, Wang-Fun Fong
Publikováno v:
Molecular Immunology. 47:1728-1738
1alpha,25-Dihydroxyvitamin D(3) (VD(3)), the biologically active form of vitamin D, may have either pro- or anti-inflammatory activities because of its diverse actions on nuclear factor kappa B (NF-kappaB). Previous studies indicated that VD(3) can e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3536ce31d1d76f50efaa16cf1ddff898
https://doi.org/10.1016/j.molimm.2010.03.004
https://doi.org/10.1016/j.molimm.2010.03.004
Publikováno v:
Immunological Reviews. 224:249-264
Both diacylglycerol (DAG) and phosphatidic acid (PA) are important second messengers involved in signal transduction from many immune cell receptors and can be generated and metabolized through multiple mechanisms. Recent studies indicate that diacyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c737f01589221029dd3cd4967f00e432
https://doi.org/10.1111/j.1600-065x.2008.00647.x
https://doi.org/10.1111/j.1600-065x.2008.00647.x
Autor:
Chi-Keung Wan, Warren J. Leonard
Interleukin-2 (IL-2), IL-4, IL-7, IL-15, and IL-21 are members of a family of type I cytokines that share the common cytokine receptor γ chain, γ c , as a critical receptor component. The gene encoding γ c , IL2RG , is mutated in humans with X-lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::824f87c3632c1ea645112f482717c4b3
https://doi.org/10.1016/b978-0-12-374279-7.10010-4
https://doi.org/10.1016/b978-0-12-374279-7.10010-4
Publikováno v:
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 262:128-134
In the present work, we have studied the feasibility of a method based on polyallyldiglycol-carbonate (PADC) films to investigate the effects of alpha particles on HeLa cervix cancer cells. Thin PADC films with thickness of about 20 μm were prepared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b361324c4bfcd5aa17a2c93a90109be
https://doi.org/10.1016/j.nimb.2007.05.009
https://doi.org/10.1016/j.nimb.2007.05.009
Autor:
Xiao-Ling Shen, Hon-Yeung Cheung, Guo-Yuan Zhu, Anfernee Kai-Wing Tse, Chi-Keung Wan, Mengsu Yang, Wang-Fun Fong
Publikováno v:
Molecular Immunology. 44:2647-2658
The mis-regulation of nuclear factor-kappa B (NF-kappaB) signal pathway is involved in a variety of inflammatory diseases that leds to the production of inflammatory mediators. Our studies using human U937 promonocytes cells suggested that magnolol,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9afd6c550933d260e2d37bd0aed85148
https://doi.org/10.1016/j.molimm.2006.12.004
https://doi.org/10.1016/j.molimm.2006.12.004
Autor:
Saibal Dey, Apurba Chattopadhyay, Chi-Keung Wan, Guo-Yuan Zhu, Xiao-Ling Shen, Wang-Fun Fong, Zhongzhen Zhao
Publikováno v:
Planta Medica. 73:212-220
Recent studies have shown that dibenzocyclooctadiene lignans may reverse P-glycoprotein-mediated multidrug resistance (Pgp-MDR) in cancer cells; however, the mechanism of action remains unknown. Through screening of herbs, we found that schisandrol A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::692451e087e5508cff4312a441748297
https://doi.org/10.1055/s-2007-967120
https://doi.org/10.1055/s-2007-967120